Duphalac 667mg/ml 500ml

Duphalac user manual

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Composition of Duphalac

Composition of 100 ml of syrup:
    lactulose - 66.7 g;
    water purified to 100 ml.

Form of issue

In pharmacy kiosks, the drug is sold as a syrup in polyethylene bottles of 200, 500 and 1000 ml with a special screw cap. In a cardboard box, in addition to the pharmaceutical preparation, a measuring cup is laid. Also, the laxative can be found in disposable polyethylene bags of aluminum foil, designed for 15 ml. Packaging, as a rule, contains 10 sachets.

pharmachologic effect

Syrup Duphalac is classified in the thematic medical literature as a laxative drug. The drug has a hyperosmotic effect, stimulates the physiological act of intestinal peristalsis, improves the absorption of calcium salts and phosphates. Also, the effects of medicinal syrup extend to nitrogen metabolism - ammonia is migrated from the blood to the intestine, where the formation of toxic products of nitrogen metabolism is largely reduced and their absorption into the lower vena cava system is inhibited.
The mechanism of the therapeutic effects of a pharmaceutical preparation consists in the cooperation of a biologically active ingredient with the natural microflora of the large intestine. The properties of lactulose make it possible to increase the number of lactobacilli, which, when broken, form low-molecular acids that reduce acidity in the lumen of the digestive tube. The result of this interaction is a decrease in osmotic pressure and an increase in intestinal contents, which is manifested in the stimulation of peristalsis and changes in the character of the stool.

Pharmacodynamics and pharmacokinetics

The laxative is used orally. Absorption of the active ingredient in the digestive tract is low. After application of the drug in almost unchanged form reaches the large intestine, where it is split by a natural microflora that populates the lumen. The complete metabolization of the pharmaceutical preparation takes place at doses of about 45-70 ml (the exact amount depends on the individual metabolic rates). If the dosages exceed these, it can be detected in the secretions in an unchanged form.

Indications for use

    severe chronic constipation (constipation);
    regulation of the rhythm of physiological emptying of the large intestine;
    softening of fecal masses during hemorrhoids or upcoming operations on the terminal sections of the gastrointestinal tract;
    hepatic encephalopathy;
    syndrome of putrefactive dyspepsia in children of younger age;
    hepatic coma and precomatosis;
    dysbiosis of the intestines. caused by the persistence of salmonella, shigella.

Contraindications

Contraindications to the use of the medicinal product include:
    increased individual sensitivity to the components of the pharmaceutical preparation;
    hereditary or acquired intolerance of the active substance;
    rectal hemorrhages not of hemorrhoidal genesis;
    galactosemia;
    colostomy and ileostomy;
    intestinal obstruction of various origin;
    suspicion of having acute appendicitis;
    diabetes mellitus (endocrine pathology is not considered an absolute contraindication for the use of medicinal syrup, but it should be applied against the background of this disease under the supervision of qualified specialists).

Side effects

Laxative Duphalac in the first days of the course of conservative treatment can cause a lingering manifestation of bloating and flatulence, which are resolved independently for two days. Abdominal pain, nausea, vomiting, diarrhea, electrolyte imbalance, as well as convulsions, arrhythmias, myalgia, excessive fatigue, headache, dizziness and weakness may also occur. In case of adverse effects of therapy, the pharmaceutical preparation is not excluded from the sanation scheme, but only corrected in a certain way by its dosage.

Syrup Duphalac, instructions for use (Method and dosage)

The laxative is intended for oral internal administration. The drug solution can be used both in diluted and undiluted form. Take all the once-only dosage in one gulp, without delaying the syrup in the mouth.

Instructions for use of Duphalac

The main purpose of prescribing a pharmacological drug is softening of the stool and treatment of constipation. For this, the syrup should be taken at the same time throughout the conservative course. It is also recommended to drink plenty of liquids during the treatment - 1.5-2 liters per day. The scheme of therapeutic dosages largely depends on the age category (the initial dosage is equal to the supporting dosage):
    adults and adolescents - 15-45 ml;
    children 7-14 years old - 15 ml;
    children 1-6 years 5-10 ml;
    children under 1 year - Up to 5 ml.
Through how much the pharmacological drug works, it is almost impossible to answer unequivocally because of the individual metabolic characteristics of each human body, however, as a rule, the therapeutic effects with constipation do not make you wait long and are noticeable on the second day of conservative treatment.

How to take a newborn?

Immediately after childbirth or at the earliest childhood, mothers often face the problem of constipation in children, because their digestive system is not yet adapted to such a diet. Also, the own microflora of the gastrointestinal tract has not yet developed enough to ensure a normal rate of fermentation of products. Because newborns are often appointed Duphalac.
Dosages of a pharmaceutical preparation are selected from the subjective sensations of the child after its administration. Typically, the amount of syrup used varies from 1 to 5 ml. Dilute the laxative in water or breast milk. Give the drug better immediately after a night's sleep or the first morning feeding, but with rapid regurgitation should be repeated manipulation. It is interesting that the "children's" therapeutic effect develops in a few hours.

How to take Duphalac in the treatment of hepatic coma and precoma?

The initial dosage of the drug is 30-45 ml of syrup 3 times a day. Then the dosage is selected individually - to avoid the adverse effects of treatment and drug overdose. The criteria for the correct amount of syrup are:
    soft stool 2-3 times a day;
    acidity of the large intestine within 5.0-5.5;
    absence of abdominal pain or other side effects.
Separately, it should be noted, after what time the drug acts, because the metabolic effects of biologically active components can not develop simultaneously. In hepatic pathologies, for example, the therapeutic effect of Duphalac is noticeable after 2-5 days, depending on the individual metabolic rate.

Instructions for the use of Duphalac for the treatment of digestive tube dysbiosis

In the treatment of the violation of quantitative and qualitative composition of the natural microflora of the large intestine, the pharmacological preparation is used not as a laxative, but as a full probiotic, as the main purpose of its purpose is to increase the fractions of lactobacilli and change the acidity of the internal environment to suppress the growth of pathological microflora. With dysbacteriosis the following dosages of medicinal syrup are used:
    children under 1 year - 1,5-3 ml;
    age category from 1 year to 3 years - 3 ml;
    preschoolers from 4 to 7 years - 5 ml;
    at school age and adult - 10 ml.

Overdose

The use of the drug in excessive amounts can lead to a pathological state of overdose, which is characterized by such manifestations as abdominal pain, diarrhea, electrolyte imbalance. In case of development of such consequences of conservative treatment, the method of application and dosage should be reduced after mandatory consultation with a qualified medical specialist.

Interaction

The combined use of Duphalac with antacids and certain antibiotics reduces its therapeutic effectiveness.
The pharmacological action of lactulose, an active component of the drug, is accompanied by a decrease in the acidity of the contents of the large intestine, and accordingly changes the release of pH-dependent active substances, for example, when treated with 5-aminosalicylic acid preparations.

Terms of sale

You can buy a laxative without presentation of an appropriate receptor blank.

Storage conditions

Abstract to the drug prescribes its storage in a place protected from direct sunlight, inaccessible to children of all age categories at a constant temperature regime from 10 to 25 degrees Celsius.

Shelf life

3 years

special instructions

In addition to the traditional therapeutic treatment, Duphalac is also actively used and veterinary practice, as the structure of the gastrointestinal tract of most mammals is practically the same. For example, it is often possible to meet the purpose of this laxative remedy for cats, because these extremely clean domestic animals swallow a certain amount of hair that accumulates in the lumen of the large intestine and leads to difficulties in defecation. Also often there are problems with the diet of pets.
Veterinary forums often hear questions about the addiction of cats to different medicines, because such a predilection for this kind of domestic animals, unfortunately, is available and has been repeatedly ridiculed in anecdotes and parables. What about Duphalache - whether the drug causes addiction, is difficult to answer. Cats do not begin to ask for a laxative drug, but use it regularly, because we can not wean the animal from "washing", because some veterinarians put forward a theory of a fairly constant consumption, which makes the addictive imperceptible.

How to take with constipation in cats?

Dosage for cats is 0.5-2 ml per animal of medium size. The amount of medicinal syrup used can be selected independently, guided by the calculation of 0.5 ml per 1 kg of the weight of the pet. Give a pharmaceutical product should be at the time of food intake, since the syrup has a characteristic sweet taste, which may not like the cat or cat at all.

How much does it take to act?

Separately, it should be noted that the therapeutic effects of constipation in pets are much faster than in humans. The active action of the pharmaceutical preparation can be observed only a few hours after the intake of the syrup.

Duphalac for children

Duphalac is actively used in pediatric practice, starting with the youngest age category, because problems with evacuation, unfortunately, are not uncommon in the daily work of a pediatrician. By the time of birth, the children's gastrointestinal tract has not yet completely finished its development, is practically clean from the beneficial microflora of the digestive tube - these are the main causes of constipation. The instruction for children on this pharmaceutical preparation is fundamentally different only in the dosages used in the conservative course of treatment.
Since the drug is often used for children, reviews about Duphalac are crowded with thematic forums and sites. Most of them are positive, because the medicinal syrup allows you to solve problems with one of the most important systems of the body. Also after the course of conservative therapy with syrup, the calmness of children after feeding, in contrast to hysterics in the presence of pathology of the digestive organs, is noted.

Duphalac for newborns

The development of the child does not end in the process of birth, as a rule, most organs and systems go through the last stages of becoming already in unfavorable conditions of the external world. This fact is observed in relation, for example, to the gastrointestinal tract, because the intrauterine nutrition of the child involves completely different organs. Against this background, newborns often have constipation, because the lumen of the digestive tube is not yet ready for traditional products.
To eliminate such pathological conditions laxative preparations of hypo-osmotic action are appointed, therefore, to the question whether Duphalac can be given to newborns, it should be positively answered positively - this medication is undoubtedly what a newborn child needs to eliminate difficulties with defecation.

How to give a newborn to Duphalac?

Pharmaceutical preparation is issued in the form of sweet syrup, therefore the instruction for newborns practically does not differ from that for the adult category of patients. The drug can be diluted with water, so that the taste is not so saturated. Give the baby syrup should be at the same time (preferably immediately after sleep), in order to develop a habit in the young body.
The laxative is a strong pharmaceutical product, therefore when Duphalac is used for infants, the dosage should be clearly adhered to in order to avoid the adverse effects of the therapeutic course or the overdose state of the active ingredients. Children from birth until the first year of life are usually prescribed 5 ml for 15-20 days, but with individual indications or contraindications, the dosage or duration of treatment may vary.

Laxative for babies: reviews about Duphalac

Metabolic processes in the body of small newborns are extremely rapid, and therefore therapeutic effects of the drug are observed in a few hours, in contrast to treatment of the adult category of patients. In this regard, reviews on the thematic forums for young mothers in the overwhelming majority characterize the drug positively. After taking a course of conservative sanitation, the child becomes more calm and less worried about parents with screaming about and without him. The frequency of defecation returns to normal (at the age of up to a year is about 4-5 times a day).

For losing weight

The problem of excessive weight in women is often found in the modern world and, of course, it is decided to solve it, of course, firstly to other ways and only after long studies come to sports and rational nutrition. There is a widespread view that you can lose a couple of extra pounds with the help of such laxatives, such as Duphalac. A large number of female audience on topical sites are asked how to drink syrup to get rid of obesity.
The correct answer will certainly be "in no way," because the laxative does not allow you to eliminate the problem of obesity, and when you abuse the drug makes the female body only worse. Due to the regular use of Duphalac for the purpose of losing weight, dehydration develops, since a large amount of water intended for absorption is excreted along with the feces. This entails a series of pathological conditions, the key of which is a total metabolic disorder.
As a result of metabolic shifts, regular headaches and dizziness occur, the external condition of the skin and its appendages changes (the nails become brittle and weak, and the hair splits, lose its healthy shine and color). How quickly does the drug work on the woman's body? When the drug is abused, the above effects will manifest themselves fully after only 1-2 months of active intake of the laxative. It should be noted that the desired change in weight in the vast majority of cases does not occur.

Duphalac during pregnancy (and lactation)

Problems with the gastrointestinal tract in almost 100 percent of cases accompany the period of pregnancy, especially constipation or constipation is often manifested. In this critical period of a woman's life, even such an innocent pathological condition as difficulty in emptying can lead to unfavorable consequences, since muscles of the rectum, perineum and uterus are innervated from one focal point of the peripheral nervous system, and accordingly strong contractions during defecation increase the tone of the muscular apparatus of female genital organs.
To eliminate the above-described danger, laxatives should be used, but not all pharmaceuticals that facilitate feces removal can be used during pregnancy. The drug should be selected in such a way that it does not have a tonic effect on smooth muscle. Most often, to solve the problem, Duphalac is prescribed, a laxative hypo-osmotic action that softens the feces due to the therapeutic effect on the natural microflora of the digestive tube.

How to take during pregnancy?

The scheme of conservative treatment Duphalac consists of two key periods - directly therapeutic and supporting sanation (performed in order to avoid subsequent relapses of the pathological condition). The minimum daily dosage of the drug is 15 ml, and the maximum dosage is 45 ml. As soon as the stool is settled and defecation does not cause difficulties, it is necessary to switch to maintenance dosages, which are equal to half of the therapeutic dosages (it is recommended to check with the attending physician, as the amount of the drug may vary depending on the results of the clinical tests).

Reviews of Duphalac during pregnancy

The drug has a good reputation among women for several reasons. First of all, of course, the pharmaceutical preparation can effectively eradicate the problems with evacuation and restore the normal defecation regime without harm to the future mother and fetus. The next, but important, positive component for Duphalac syrup is the almost complete absence of side effects during the course of conservative treatment. Unlike other laxatives, Duphalac does not cause flatulence, bloating, or flushing pain.

Duphalac during lactation

Separately, we should touch on the topic - can a nursing mother take this medication. Duphalac is not absorbed from the cavity of the digestive tube, but selectively acts on the natural microflora and nitrogen metabolism, and accordingly for the main biologically active component of Lactulose there is no way to get into breast milk. Because to use Duphalac during lactation is definitely possible, because it does not hurt the baby or the female body.
However, in view of the increased susceptibility of the mother immediately after childbirth, the prescribed dosages should be strictly followed. If it is necessary to undergo a course of treatment with a laxative, it is recommended to lie in a hospital, in which case a qualified specialist will always be able to indicate how much and when to take Duphalac better. The question of how long it is possible to take a pharmaceutical drug should also be shifted to a gynecologist or therapist. As a rule, after noticeable improvement in the quality of the stool and elimination of problems with defecation, Duphalac during breastfeeding is canceled without undergoing maintenance therapy.

Reviews about Duphalac

Reviews of Duphalac at various pharmaceutical forums are mostly positive in view of the special effectiveness of the drug even in the most clinically difficult situations. Laxative syrup allows not only to get rid of difficulties in the process of excrement, but also to strengthen the microbiological component of the gastrointestinal tract, because the active ingredient increases the population of such useful lactobacilli in the lumen of the digestive tube.
Laxative develops its therapeutic effect gently and without the presence of a long list of side effects, because the pharmaceutical drug is actively used in pediatric practice to help newborns with adaptation to solid food and preparation of the digestive system for further physiological existence. When receiving newborns reviews about Duphalac spark from joyful emotions and compliments towards the pharmacists, because the drug helps in a few hours, after which the child becomes much more calm and less screaming.
Duphalac is actively used in pregnancy, as it has no toning effect on the smooth musculature of the rectum and uterus. This means that the use of a pharmaceutical laxative can not lead to any negative consequences for the fetus. For the mother, in turn, the drug helps to effectively get rid of the unpleasant sensations caused by constipation, a problem so common in the period of pregnancy.
Separately, it should be noted that unlike some laxatives, Duphalac is not absorbed into the main bloodstream, and therefore it can be used freely in breastfeeding, since there is not even a theoretical possibility of getting the active ingredients into the mother's milk and for babies there is no danger even when passing a very long course of conservative therapy by a woman after childbirth.
In addition to being used for medicinal purposes, Duphalac syrup can be prescribed for specific diagnostics. So, for example, preparation for a colonoscopy necessarily includes a laxative, and since this drug has a small list of side effects and, as a rule, is tolerated by patients well, Duphalac is appointed. Based on the reviews, the use of the pharmaceutical preparation also allows a few to smooth out the unpleasant sensations in this type of proctological examination.
To lose weight, the drug should not be used, of course, since it is possible to develop extremely unfavorable pathological consequences, such as general exhaustion of the organism, violation of all exchange types, water-electrolyte balance and, as a consequence, the development of deficient states with corresponding dystrophies throughout the body. That is why the reviews of adult women about the pharmaceutical product can somewhat spoil the reputation of Duphalac. But in this context, it is not the therapeutic effect of the syrup that is being evaluated, but only the invented methods of losing weight.