Orlistat 60mg #42

Instruction for orlistat

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Composition

Active component of this drug is the same name substance orlistat.

Form of issue

Orlistat is available in capsules, inside which there is a crystalline powder of light color.

pharmachologic effect

Tablets have an effect that inhibits gastrointestinal lipases.

Pharmacodynamics and pharmacokinetics

This preparation is characterized by high lipophilicity and good mixing with fats. Also, its active association with the center of pancreatic and gastric lipases is noted, which leads to their inactivation. As a result, the penetration of triglycerides into the blood is blocked. All this causes a shortage of energy, leading to the mobilization of fat from the depot. Thus, Orlistat can reduce the amount of visceral-abdominal fat in the total mass. In addition, hypercholesterolemia decreases, cholesterol solubility decreases, tissue sensitivity to insulin decreases, and hyperinsulinemia decreases, which contributes to the elimination of visceral-abdominal fats.
In this orlistat almost does not get into the blood, so it does not have a systemic effect on the human body. Metabolism occurs in the walls of the intestine, resulting in the formation of inactive metabolites. From the body the substance is excreted with feces. The period of complete elimination is 5 days.

Indications for use

Orlistat - what is it?

Orlistat is a drug that is a specific inhibitor of gastrointestinal lipases. The drug is actively used to reduce excess weight.

This drug is prescribed for:

    the treatment of obesity, in order to reduce and maintain weight, combined with diet;
    reducing the risk of re-increase after its decline.

Contraindications

It is not recommended to take Orlistat with:
    hypersensitivity;
    syndrome of chronic malabsorption;
    cholestasis;
    age under 12 years;
    nephrolithiasis;
    hyperoxaluria;
    lactation, pregnancy.

Special conditions

This drug is not recommended for use in childhood, lactation and pregnancy, as for such patients safety and efficacy are not fully established. It is not known what effect the substance has on the fetus, as well as whether its penetration into breast milk is possible.
Use of Orlistat is also prohibited in pregnancy, since weight loss during this period can cause harm to the pregnant woman and cause adverse effects on the fetus. Modern specialists, of course, advise future mothers to follow the body weight, allowing a minimum increase, but not weight loss. This applies even to those women who are overweight or obese.

Side effects

The intake of Orlistat may be accompanied by undesirable effects in the activity of the digestive tract:
    oily discharge from the rectum;
    flatulence;
    "Fat" chair;
    frequent defecation;
    imperative urges for defecation;
    incontinence of stool.
As a rule, the cause of side effects from the gastrointestinal tract is a high fat content in food. Therefore, to avoid this, you need to eat moderately hypocaloric food, which contains about 30% of the daily fat rate.
In addition, in the first 1-4 weeks there may be deviations in the nervous system, for example: headache, sleep problems, dizziness, anxiety.
Sometimes the reception of the drug causes intestinal steatoria due to violations of fat absorption, as well as deficiency of fat-soluble vitamins.

Orlistat instruction (Method and dosage)

The drug is intended for internal reception. According to the Orlistat application, the single dose is 120 mg, which is taken at each main meal or an hour after, but no more than 3 times a day.
When food contains a small amount of fat, it is allowed to skip the reception of capsules.

Overdose

Cases of overdose during the reception of Orlistat occur rarely. Usually they are manifested by disorders of the gastrointestinal tract. As a rule, systemic effects related to the lipase inhibitory properties of the drug are quickly eliminated after its withdrawal.

Interaction

Simultaneous reception of Orlistat with Cyclosporine may reduce its plasma content. Therefore, between the reception of these drugs should be observed interval of at least 2-3h.
It is also found that Orlistat reduces the absorption of beta-carotene, which is part of food additives. Its effect on the absorption of vitamin E.
Sometimes the combination of Orlistat with levothyroxine sodium causes the development of hypothyroidism. Such cases require monitoring of the thyroid gland functions, therefore, it is necessary to observe the interval between receiving drugs not less than 4 hours.

Terms of sale

Capsules Orlistat can be bought without a prescription.

Storage conditions

To store the medicine is intended a dark and cool place, protected from children.

Shelf life

2 years

Alcohol

It is established that the use of alcohol does not have a particular effect on the pharmacokinetics or pharmacodynamics of this drug.

Reviews about Orlistat

As evidenced by numerous reviews about Orlistat on the forums, the problem of excess weight is a concern for many people. This is especially common in women after childbirth. They begin to try a variety of diets and medications themselves, but this approach rarely becomes effective.
If the ladies turn to specialists, they perform a competent selection of a diet with the possible use of special medicines. At the same time, doctors' reviews of Orlistat show that this drug helps to quickly reduce weight and keep the form obtained. It is also possible the appointment of its main analog, the drug Xenical. Of course, the process of losing weight requires a serious approach with a change in lifestyle, choice of diet, regular exercise, and so on.
It should be noted that the reviews of slimming women, mostly positive. They report that while taking this remedy, they were able to lose at least 10 kg in six months. After that, the weight starts to go not so fast, but still stably decreases.
However, not everyone is happy with the action of Orlistat. Some women say that taking this medication did not bring them any result, moreover, it caused the development of side effects associated with the activity of the gastrointestinal tract. As a rule, such messages leave ladies with a weight of more than 100 kg. At the same time they write that they excluded from the diet sweet and flour, and other features of nutrition and life do not describe.
As you know, extra pounds accumulate over the years and quickly get rid of them is not easy. The process of losing weight requires an integrated approach for a long time. It is desirable to fight overweight under the supervision of a specialist, as it will allow you to choose the right program and get a guaranteed result.