Orsoten Slim 60mg #84

Orsoten Slim for weight loss user manual

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Orsoten Slim is a medicinal preparation that contains a substance that inhibits the activity of digestive lipases. As a result of its action, the absorption of fats is disrupted, and a gradual decrease in body weight occurs.
The active ingredient is orlistat. It is an inhibitor of long-acting digestive lipases. By covalent bonding with the active site of serine, lipase of the stomach and pancreas, it causes the inactivation of the enzyme, which loses the ability to break down food fats to sucked free fatty acids and monoglycerides. Unhydrolysed fats can not be absorbed, which leads to a reduction in the amount of calories absorbed and a decrease in weight.
The action of the drug develops in the lumen of the stomach and small intestine, that is, without orlistat entering the systemic circulation. According to the research, when taking 1 capsule (60 mg) 3 times a day, orlistat blocks the absorption of about 25% of fats obtained from food.
At the same time, when Orsoten Slim is taken, the following parameters decrease:
    waist circumference;
    the amount of cholesterol in the blood;
    level of low density lipoproteins.
Six months after the start of orlistat therapy, the average cholesterol concentration decreases by almost 2.5%, low-density lipoproteins - by 3.5%. The waist through this time interval decreases, approximately, on 4,5 see.
Orsoten slim is a non-prescription drug.

Form of issue and composition

Capsules of gelatin with a white body and a pale yellow lid, No. 21 * 2 and 21 * 4 in the package. The dosage of orlistat in the capsule is 60 mg, the microcellulose is 22.2 mg.
The production belongs to the company KRKA-Rus (Russia).

Indications for use

The drug is used to reduce weight in people suffering from overweight of over 18 years of age. Orsoten Slim should be combined with a low-calorie diet with a reduced fat content of food.

Contraindications

Orsoten Slim has a number of contraindications that must be considered before applying this medication:
    individual sensitivity to inhibitors of lipases or excipients;
    syndrome of chronic malabsorption;
    administration of cyclosporine;
    reception of anticoagulants of indirect action (warfarin);
    reception of sitagliptin;
    cholestatic syndrome;
    period of pregnancy and lactation;
    age younger than 18 years.
Orlistat is limited to use in hyperoxaluria in history and kidney stone disease with the formation of calcium oxalate stones.

Dosing and Administration

Capsules are taken orally 1 unit 3 times a day. Reception can be done before meals, during meals or for an hour after.
In case of skipping meals or eating low-fat food, you do not need to take Orsoten Slim.
The daily dosage of the drug is 3 capsules and should be taken only in the recommended amount. The duration of therapy should not exceed 6 months. The result of weight reduction is desirable to discuss with a specialist.
If after 12 weeks of treatment the weight reduction is less than 5% of the initial mass, it is necessary to consult with a specialist about the rationality of further use of the drug.

Side effects

The most common side effects are related to the digestive tract. Most often, they are observed in the initial period of treatment, have a mild severity and are reversible. Compliance with dietary intake with the consumption of low-fat foods reduces the risk of their development.
Side effects can be the following:
    digestive system: oily discharges from the anus, the release of gases with a small amount of intestinal contents, urgent desires for emptying, fatty stool, abdominal pain, abdominal pain, uncontrolled defecation, diarrhea, frequent emptying, rectal bleeding, inflammation of diverticula;
    hematopoiesis: a decrease in the level of prothrombin and an increase in the INR rate in patients taking Orsoten Slim simultaneously and anticoagulants of indirect action;
    skin: bullous eruptions;
    immunity: hypersensitivity reactions, including itching, skin rashes, hives, Quincke's edema, bronchospasm and anaphylactoid reactions;
    hepatobiliary system: cholelithiasis, hepatitis, an increase in the parameters of the enzymatic system of the liver.

special instructions

    there is no reliable data on the safety of taking the drug during pregnancy, so the use in this period is contraindicated;
    the use of Orsoten Slim during lactation is contraindicated, since studies on the penetration into breast milk have not been performed;
    information on the intake of orlistat in old age is absent;
    the effects of orlistat in patients with liver and / or kidney dysfunction have not been studied, but considering that the absorption of the drug is very low, dosage adjustment in this category of persons and in old age will not be required;
    when taking the drug, you must follow a diet and exercise;
    food during treatment should be divided, balanced, with moderate calorie. The amount of fat should not exceed 30% of the total caloric intake per day. It is also necessary to follow the recommendations for physical activity. After the treatment, Orsotenom Slim is recommended to follow diet and physical activity;
    orlistat increases the fat content in the stool after 1-2 days from the beginning of therapy. After the termination of reception the maintenance of fat in a feces usually returns to an initial level within 2-3 days;
    a diet with low-fat foods consumption significantly reduces the risk of developing undesirable phenomena on the part of the digestive tract;
    orlistat may reduce the full absorption of hydrophobic vitamins, which are retinol, beta-carotene, calcipherol, tocopherol and vitamin K. Therefore, when treating Orthotenum, it is desirable to take a multivitamin preparation containing the listed substances before bedtime;
    with weight loss, most often, the values ​​of carbohydrate metabolism improve, so patients suffering from insulin-dependent diabetes should before using Orsoten slim consult with a doctor and, if necessary, adjust the dosage of hypoglycemic agents;
    weight loss may be accompanied by a decrease in blood pressure and cholesterol. Patients who take antihypertensive or hypolipidemic drugs need to receive specialist advice and, if necessary, adjust the dosage of the drugs taken;
    when studying the combination of orlistatata with oral contraceptive interaction was not noted. But, it should be borne in mind that a decrease in the contraceptive effect can be mediated and lead to an unwanted pregnancy. Therefore, when acute diarrhea occurs, it is recommended to use ancillary contraceptive methods;
    in the presence of kidney dysfunction, you need to get a doctor's advice, in view of the likelihood of the occurrence of oxalosis and nephropathy;
    when treated with amiodarone, warfarin, or other anticoagulant means of indirect action, it is recommended to consult a specialist before taking a lipase inhibitor, since the combination of these drugs may affect the value of INR;
    if there is jaundice of sclera or skin, itching, darkening of urine or anorexia, you should immediately consult a doctor;
    Capsules do not affect the ability to carry out potentially hazardous activities.

Drug Interactions

    the administration of Orsoten Slim and cyclosporine is simultaneously contraindicated, since there is evidence of a decrease in the concentration of cyclosporine in the blood as a result of this combination. This can lead to a decrease in the immunosuppressive action of cyclosporine and a decrease in the effectiveness of treatment;
    the combination of warfarin or other representatives of anticoagulant means of indirect action with Orsotenom Slim can cause a decrease in the level of prothrombin in the blood and a change in the INR;
    when taking Orsoten slim, deterioration in the absorption of fat-soluble vitamins, including retinol, beta-carotene, calciferol, tocopherol and vitamin K, is possible;
    due to the lack of information on the combination of Orsoten with the acarbose, such a combination is undesirable;
    combined therapy with orlistat and amiodarone may lead to a decrease in plasma. In this regard, simultaneous reception of two drugs is possible only according to the appointment of a specialist;
    As a result of combining orlistat with levothyroxine, cases of development of hypothyroidism were noted. When taking these substances, you must carefully monitor the status of thyroid functions, and observe no less than 4-hour interval between medications;
    the drug does not interact with the simultaneous use of antidepressants, phenytoin, sibutramine, phentermine, lipid-lowering agents, biguanides, digoxin, nifedipine, losartan and alcohol.

Analogues

Orsotenum slim with a dosage of orlistat is produced under the trade name Orsoten. It is also available in the form of capsules. It is used to treat obesity in people with a body mass index of over or equal to 30 kg.
Another analogue of Orsoten Slim is: Xenical

Terms and conditions of storage

Capsules should be stored in the original packaging at room temperature, protected from access by children. The product is suitable for use for 3 years from the date of manufacture.