Orlistat 120mg #42

Orlistat instruction for use

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Orlistat is a drug for weight loss - an inhibitor of gastrointestinal lipases.

Form of issue and composition

Orlistat is available in the form of capsules for ingestion of a bright blue color with an inscription on the body of the lid in the Latin letters "Orlistat120". The drug is packed in blisters of 21 pieces in a cardboard box with the attached description.
The main active component of the drug is Orlistat in the form of pellets, 1 capsule contains 120 mg of active ingredient. Gelatin and a number of chemicals act as auxiliary components.

pharmachologic effect

The drug Orlistat is an inhibitor of the gastrointestinal lipase with a pronounced prolonged action. The drug when taken inside begins its action directly in the stomach and small intestine, where the inactivation of enzymes. Inactivated enzymes lose their ability to break down fats from food, which enter the body in the form of triglycerides. Triglycerides are not absorbed, which leads to a decrease in the intake of calories in the body and, as a consequence, a decrease in the body weight of the patient. The therapeutic effect of the drug is observed exclusively in the walls of the small intestine and stomach, that is, the active substance of the capsules is not absorbed into the common bloodstream and does not affect the internal organs.

Indications for use

Capsules are indicated to patients for the treatment of obesity or overweight in combination with a low-calorie diet.
Capsules can also be given to people suffering from excess weight against type 2 diabetes and the use of hypoglycemic drugs.

Contraindications

Capsules Orlistat are contraindicated in patients with the following conditions:
    Lactase insufficiency or malabsorption syndrome;
    Dysfunction of the liver and bile ducts;
    The presence of concrements in the bile ducts, as a result of which the outflow of bile is disturbed;
    Increased individual sensitivity to the components of the drug components.

Dosing and Administration

The drug is intended for long-term treatment of patients who are obese or overweight in combination with a diet low in carbohydrates.
Adults and patients older than 12 years of age, the recommended dose of Orlistat is 120 mg or 1 capsule at a time. In a day the drug is taken as many times as a person eats. The capsule is drunk while eating, without opening it, with a sufficient amount of water. If the patient eats food without fat, you can skip the capsule, as well as if you missed the meal, you can do without the drug. The daily food norm should be divided into 3 doses.
Patients with an increased body weight on the background of taking hypoglycemic medications Orlistat drug is prescribed 1 capsule at each meal. The optimal daily dose of the drug is 3 capsules, with a deliberate increase in dosage the effect of the drug will not be more pronounced.
Clinical experiments in the use of the drug in elderly, children under 12 years and patients with chronic renal failure have not been carried out, therefore, in order to prevent risks to people of this category, capsules are not treated.

Use during pregnancy and breastfeeding

The drug was tested in pregnant female animals. During the research, embryotoxic or teratogenic effects on the fetus were not detected, however, despite this, Orlistat should not be prescribed for the treatment of overweight to pregnant women.
It is not known whether Orlistat is excreted in breast milk, therefore, during the lactation period, Orlistat capsules are not treated with capsules. If therapy is necessary, the question of interrupting breastfeeding of the baby should be resolved.

Side effects

In most cases, the capsules of the drug were normally tolerated by patients, but those with increased sensitivity to Orlistat complained of the development of the following adverse reactions:
    Diarrhea;
    Stomach ache;
    Nausea;
    Increased gas formation;
    False urge to defecate;
    Oily discharge from the rectum;
    Headaches, weakness;
    Development of depression and feelings of anxiety.
In rare cases, there was a rash on the skin of an allergic nature, urticaria. All side effects are not dangerous, they pass by themselves without medical intervention immediately after drug cancellation or dose reduction.

Overdose

Cases of drug overdose have not been described. To avoid undesirable reactions, it is not recommended to take Capsules more than 3-4 times a day, otherwise there is an increase in the above-listed side effects.

Interaction with other drugs

During treatment with Orlistat, patients should refrain from consuming alcoholic beverages.
There was no adverse effect when the capsules were combined with Digoxin, Warfarin, oral contraceptives, Nifdipin, oral anticoagulants.
Against the background of treatment with capsules of the drug in patients, a decrease in the absorption of vitamin D, A and E can be observed, therefore it is impossible to combine these preparations together. Vitamins can be taken no earlier than 2 hours after taking Orlistat.
In patients with epilepsy who are forced to take anticonvulsant drugs for a long time, against the background of Orlistat capsules treatment, the epileptic seizures increased and intensified.

Special instructions

The drug is effective for controlling body weight - reducing excess weight and maintaining the achieved result. Treatment with the drug is especially recommended for patients with excess weight from the risk group - people with arterial hypertension, atherosclerosis, diabetes, hypercholesterolemia.
Since treatment with the drug is recommended to combine with a diet low in fat and carbohydrates, to provide the body with all the necessary beneficial substances, the patient is recommended to take multivitamin complexes simultaneously. The daily volume of food should be divided into 3 doses.
The risk of developing the above adverse reactions increases with prevalence in the diet of foods rich in fats and carbohydrates (fatty meats and fish, refractory fats, confectionery, rich or fresh pastries).
In patients with type 2 diabetes mellitus, a decrease in body weight with Orlistat capsules improves metabolic processes, which may allow under the supervision of a doctor to somewhat reduce the daily dose of hypoglycemic agents.

Storage conditions

Keep the drug away from children in a cool dry place in the original package. The shelf life of the capsules is indicated on the package, after this period the drug should not be taken orally.