Orsoten 120mg #42

Orsoten for weight loss instruction for use

You can buy Orsoten here

Composition

The composition of one capsule of Orsoten is as follows: it contains 120 mg of orlistat, and also an auxiliary ingredient - microcrystalline cellulose.

Form of issue

Hard gelatin capsules can have a color ranging from white to whitish-yellow, they contain microgranules or a mixture of microgranules and white powder. Capsules can contain agglomerates, which are very easily crumbled when they are pressed.
Capsules are contained in a blister pack of 7 pieces, in a cardboard bundle contains 3, 6 or 12 such blisters. Also capsules can be packed in a blister for 21 pieces, in a cardboard package contains 1, 2 or 4 blisters with capsules.

pharmachologic effect

Diet pills Orsoten suspend the process of absorption of fats in the intestine. The drug has an active substance orlistat, which specifically inhibits gastric and pancreatic lipases. Due to the appearance of covalent bonds with the gastric and pancreatic lipase orlistat does not allow the splitting of fats that are contained in food. If triglycerides do not split, they are not absorbed from the digestive tract. They are excreted from the body with feces. As a consequence, fewer calories enter the human body. Consequently, the annotation indicates that Orsoten helps to reduce body weight. There is no systemic absorption of the active component.

Pharmacodynamics and pharmacokinetics

At a dose of 60 mg three times a day, the drug roughly blocks the absorption of 25% fat from food.
Already after 24-48 hours after using the drug, the concentration of fat in the intestinal contents of the intestine increases. If the drug is canceled, the concentration of fat in the intestine returns to the same parameters as before taking it, after 48-72 hours.
If the device is taken by an adult whose body mass index is more than 28 kg / m2, at a dosage of 60 mg three times a day, its effectiveness is enhanced by the combination of treatment with a low-calorie diet. Basically, body weight is actively lost in the first six months of taking the drug.
In addition to reducing weight, taking orlistat at a dose of 60 mg three times a day helps reduce cholesterol. In addition, people who undergo treatment with the drug, note a decrease in waist circumference.
According to the studies, minimal absorption of orlistat is noted. When using therapeutic doses of a drug in blood plasma, unchanged orlistat is present only sporadically, its concentration is very low. There are also no signs of cumulation.
Orlistat binds to plasma proteins more than 99%. At the minimum, it is able to penetrate into the red blood cells.
Metabolism is noted in the walls of the small intestine and stomach. About 97% of the substance is excreted through the intestine, including 83% - as unchanged orlistat. Only about 2% of the total dose is excreted by the kidneys. Complete elimination from the body occurs in 3-5 days.

Indications for use

Orsoten and Orsoten Plus are indicated for admission to people who need to reduce body weight. It is prescribed for adult patients who are overweight (body mass index exceeds 28). The drug can be taken only if a low-calorie diet is observed.

Contraindications

Contraindications for the drug are as follows:
    high sensitivity to orlistat;
    syndrome of chronic malabsorption and cholestasis;
    children and adolescence.
With care, Orsotenum is prescribed for the following diseases:
    diabetes mellitus type 2;
    impaired renal function;
    hypothyroidism;
    epilepsy;
    change in the volume of the intercellular fluid.

Side effects

With the regular administration of capsules, some side effects may develop. In most cases, this is a gastrointestinal reaction associated with the pharmacological action of the drug.
    Digestive system: the appearance of oily discharge from the rectum, the release of gases, periodic imperative urges for defecation, pain in the abdomen, loose stools, stool incontinence, more frequent defecation.
    Hematopoiesis system: an increase in MHO indices, a decrease in the concentration of prothrombin.
    Skin: the appearance of bullous rash.
    Allergic manifestations: urticaria, rash, itching, bronchospasm, anaphylaxis, angioedema.
    There may be minor rectal bleeding, hepatitis, diverticulitis, cholelithiasis, increased activity of liver enzymes.
If unwanted effects occur, be sure to consult a doctor so that he can determine whether to continue treatment.

Instructions for use Orsoten (Method and dosage)

The drug is taken orally, in the process of taking food or for one hour after the end of the meal.
The Orsoten Slim Instruction notes that the patient should adhere to a low-calorie diet, where, in terms of calories, contains no more than 30% of fats. The food should be evenly divided into three meals. How long it takes to take the remedy, how to take capsules correctly for slimming capsules, and also the individual dosage should be determined by the doctor.
As a rule, adult patients are prescribed ingestion of 120 mg of orlistat three times a day, that is, during or after each meal. If there was no meal, or the food did not contain any fat, the capsule can not be taken.
The maximum dose of Orsoten per day is 3 capsules. If the drug is taken in a dose exceeding 360 mg per day, its effectiveness does not increase, but the risk of side effects increases substantially.
If the patient's body weight is reduced by less than 5% in 12 weeks, Orsoten should be discontinued.
Even before taking the drug, it is recommended that you follow a diet and exercise regularly. Proper nutrition and sport should also be practiced after stopping the taking of capsules.

Overdose

Information about overdose, as well as negative reactions observed due to an overdose, are absent. If there was a significant overdose of orlistat, you should always consult with your doctor. It is necessary to monitor this patient for 24 hours. All systemic effects of the active substance are rapidly reversible.

Interaction

If you simultaneously take cyclosporine and orlistat, there is a decrease in the concentration of cyclosporine in the blood plasma. As a consequence, its immunosuppressive activity decreases. Contraindicated concurrent treatment with these drugs.
Admission orlistat and warfarin or other oral anticoagulants leads to a change in the value of MHO.
Treatment with orlistat leads to impaired absorption of a number of fat-soluble vitamins.
Do not use orlistat and acarbose at the same time due to the lack of data on their interaction.
Simultaneous reception of amiodarone with orlistat diminishes the concentration of amiodarone in the blood plasma. Use these medicines at the same time can only be after the recommendation of a specialist.
There is no interaction of Orsoten with Phenytoin, Atorvastatin, Amitriptyline, Fluoxetine, Phentermine, Sibutramine, Digoxin, Losartan, ethanol, oral contraceptives, as well as with pravastatin, biguanides, fibrates.

Storage conditions

Store at temperatures between 15 and 25 degrees Celsius. The drug should be protected from children.

Shelf life

You can store Orsoten for 2 years.

special instructions

It is necessary to emphasize patients' attention to the fact that if the low-calorie diet is not followed and the capsules are taken at the same time, the probability of side effects increases.
If people who use oral contraceptives and simultaneously take Orsoten note the appearance of diarrhea, they should use additional methods of protection, in particular, barrier ones.
Multivitamin preparations for Orsoten should be taken before bedtime, as orlistat disturbs the absorption of certain vitamins.
People taking hypoglycemic drugs should consult a doctor before starting the course of treatment for weight loss capsules, which will adjust the dosages of hypoglycemic drugs.
With a decrease in the weight of a person, there may be an improvement in blood pressure, lowering cholesterol. Therefore, people taking medications to reduce blood pressure, as well as means to prevent hypercholesterolemia, while taking Orsoten, should consult a doctor.
If rectal bleeding develops during orlistat treatment, it is necessary to consult with a doctor.
Reception Orsoten does not affect the ability of a person to drive vehicles or work with precise mechanisms.
Due to minimal absorption of orlistat, dose adjustment for elderly patients and for people suffering from impaired renal and hepatic function is not necessary.

Analogues

Analogues of the drug Orsoten are medicines Xenical, Orlistat, Orsoten Slim, etc. When choosing such medications, it is recommended to consult with a doctor. It is not necessary to be guided exclusively by the cost of the medicine. In addition, some drugs have a higher cost.

Xenical or Orsoten - which is better?

The testimonies indicate that there is no clear answer to this question. The effectiveness of the effects on the body of Orsoten and Xenical drugs depends on how correct and regular is the taking of capsules, whether a person is engaged in sports, whether he follows a diet. Both drugs are used in the complex treatment of obesity. Both agents belong to the same pharmacological group, have a similar active substance and are inhibitors of gastrointestinal lipases. Determine which particular drug should be chosen by a doctor, assessing the individual characteristics of a person and his problems.

Children

It is not used to treat children and adolescents who are under 18 years old.

For losing weight

The drug is used to treat obesity.
Answering the question about the difference between Orsoten and Orsoten Slim, one should first of all consider that orlistat is an active substance in both preparations. Only the dosage differs - in the Orsoten capsule 120 mg of the active substance is used, and in Orsoten Slim - 60 mg. Choosing a drug for weight loss, you should consider this difference.

In pregnancy and lactation

There are no results of clinical studies of the effect of the drug during pregnancy and during breastfeeding. Therefore, the drug is not used to treat pregnant women and nursing mothers.

Reviews

On different sites and forums there are numerous reviews on Orsoten for weight loss. In most cases, reviews about Orsoten Slim and Orsoten Plus show the effectiveness of this drug. Reviews thin can often contain information about how many kilograms helped a person lose weight a drug. As a rule, it is noted that the diet pills 120 mg allow you to lose 5-7 kg for one month.
It should be borne in mind that the reports of slimming about Orsoten Slim and Orsoten indicate that the most effective effect of the drug is noted when combining its reception with a low-calorie diet. Almost every active forum for losing weight contains a discussion of how safe this means for losing weight. As a rule, it is noted that the medicine provokes side effects in the event that a person during the treatment does not reduce the usual amount of fat in the diet.
The doctors' comments about Orsoten are also mostly positive. They approve of this drug as an analogue of Xenical, while noting that the reception of the remedy must necessarily be practiced with a diet and with an active lifestyle.