Cefazolin for inj 1000mg #1

Cefazolin user manual

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Composition

The recipe in Latin informs that in one bottle the drug contains Cefazolin without any admixture of additional components.

Form of issue

The medication is available in the form of a yellow-white or white powder that dissolves for intramuscular or intravenous injection. The drug is packed in vials. Such form of release as Cefazolin in tablets is not for sale.

pharmachologic effect

This drug is a semi-synthetic antibiotic with antibacterial action of a wide spectrum.

Pharmacodynamics and pharmacokinetics

Pharmacological action of the drug is based on blocking the biosynthesis of the cell walls of microbes. Antibiotic Cefazolin is active against gram-positive (Streptococcus spp., Staphylococcus spp.) And Gram-negative bacteria (Klebsiella spp., Escherichia coli, Treponema spp., Haemophilus influenzae, Proteus mirabilis, Neisseria gonorrhoeae, Enterobacter aerogenes).
The drug is poorly absorbed from the digestive tract with internal application, therefore it is used for intravenous and intramuscular injections. After intramuscular injections at a dosage of 0.5 g, the maximum concentration is observed after 1-2 hours. The connection with plasma proteins is about 85%.
The active substance of the drug penetrates into the bone tissue, as well as pleural, ascites and synovial fluid, but is not detected in the nervous system.
The half-life of the drug is about 1.8 hours. The drug is excreted in the urine in an unchanged form.
With intramuscular injections, about 80% of the dose is withdrawn after 24 hours. In the case of kidney dysfunction, the half-life of plasma is increased.

Indications for use Cefazolin

Indications for use Cefazolin has the following:
    infection of the bile and urinary tract;
    infectious diseases of the respiratory tract;
    inflammation in the abdominal cavity and pelvic organs;
    blood poisoning;
    peritonitis and sepsis;
    skin infections after burns, surgical interventions and wounds;
    inflammation of the heart;
    infection of bones and joints;
    venereal diseases;
    infectious skin diseases;
    mastitis.
From which the drug will be effective in each case, it is necessary to consult a specialist. Only a doctor knows the exact indications for the use of Cefazolin. For example, he can recommend a drug for angina, skin infections or blood infection.
The medicine is also used in veterinary practice for cats. The injections help with blood infections, peritonitis, meningitis, and many infectious diseases.

Contraindications

The main contraindications to the use of the drug: an individual intolerance and age of up to 1 month.

Side effects

The use of medication can cause the following side effects:
    organs of the digestive system: diarrhea, nausea, vomiting;
    chemotherapeutic action: candidiasis, pseudomembranous colitis;
    allergies: urticaria, eosinophilia, pruritus, fever;
    local reactions: painful sensations in the place of intramuscular injection.
In rare cases transient increase in liver transaminase activity, anaphylactic shock, arthralgia, angioedema, leukopenia (in reversible form), thrombocytopenia, neutropenia, renal dysfunction are noted.

Instructions for the use of Cefazolin injections (Method and dosage)

When Cefazolin injections are prescribed, the instructions for use inform that the dosages and the duration of the course may vary depending on the disease and the individual sensitivity of the patients. Daily dosage for adults from 1 to 6 g. Injections do 2-3 times daily. Therapy is designed for a maximum of 7-10 days.
The drug is given in / m or / in. Depending on this, they decide how to plant Cefazolin. With intramuscular injection, the drug is diluted with water or a solution of sodium chloride. For intravenous injections, mainly sodium chloride is used. In this case, the drug is injected slowly. The administration time is approximately 5 minutes.
If a patient is given a dropper, the antibiotic is usually diluted with glucose, and sodium chloride is used only in rare cases.
For the treatment of inflammation of the heart, joints, purulent pleurisy, bones, abdominal cavity, infection of blood, 1 g of the drug is administered 3 times every day. With dysfunction of the kidneys, the dosage should be reduced in half.
The drug can not be combined in one syringe with other antibiotics.
In addition to water and sodium chloride, the drug is also sometimes bred by Novokain. This is an anesthetic for topical application, with which you can reduce pain when you enter. In medical practice, this drug has been used for a long time, so there is an established scheme, how to plant Cefazolin Novocain. The latter is taken at a concentration of 0.25%. Before you dilute Novokainom this drug, no additional manipulation is required. It is enough only to introduce 2-3 ml to the antibiotic, and then shake well. The result is a ready-made solution for single use.
According to some indications, the drug is also used in veterinary practice, instead of using tablets. In this case, he is bred in Lidokain or Novokain. Dosage for cats depends on the weight of the pet, it is calculated so that 10 mg was 1 kg. Therapy lasts 5-10 days. Before using the medication you need to consult a veterinarian.
Often as an analogue of the drug for people, Cefazolin Akos is used. It is also administered by intramuscular and intravenous injections (jet and drip). Instructions for use Cefazolin Acos reports that the average daily dosage for adults is 1 g. They need to be administered 2 times a day. The maximum dose per day should not exceed 6 g. If necessary, the frequency of application can be increased to 3-4 times a day. The average duration of therapy is 7-10 days.
The average daily dosage for children is 25-30 mg / kg, and in case of severe infections - 100 mg / kg.
When dysfunction of the kidneys are adjusted.
For intramuscular injections, an antibiotic in a dose of 500 mg is mixed with 2 ml of water, 1 g diluted in 2.5 ml of water. For intravenous administration, the drug is mixed with 5 ml of water and injected for 3-5 minutes.

Overdose

Administration of the drug in elevated doses can cause dizziness, headache and paresthesia. In people with kidney failure in a chronic form, neurotoxic events may appear. Cramps, tachycardia and vomiting are noted.
In the event of toxic reactions and signs of an overdose, excretion of the drug can be accelerated by the use of hemodialysis.

Interaction

When the drug is combined with aminoglycosides, Rifampicin, Vancomycin, synergism of the antimicrobial effect is noted. Aminoglycosides increase the likelihood of kidney damage. The drug is incompatible with them.
It is undesirable to combine medication with anticoagulants and diuretics.
Interaction with agents that inhibit tubular secretion, increases the active substance level of the drug in the blood, increases the likelihood of toxic reactions and slows down time.

Storage conditions

Optimum storage conditions - dry and dark place. The temperature is not more than 5 ° C.
Shelf life - 2 years.

Cefazolin for children

Cefazolin is divorced only in Novocain or Lidocaine solutions, depending on individual tolerability. As a rule, lidocaine has a more pronounced anesthetic effect.
The solution is prepared immediately before use. Dosage of Cefazolinum to children is calculated based on the nature of the disease and the individual tolerability of the drug.

Cefazolin during pregnancy (and lactation)

When Cefazolin is used during pregnancy, it has almost no negative effect on the fetus and health of a woman. However, it should be appointed only under the condition of supervision by a specialist. To use Cefazolin during pregnancy and lactation without the supervision of a doctor is dangerous.

Reviews of Cefazolin

Reviews about Cefazolin are mostly positive. In the absence of a negative reaction, it is very effective. The only drawback, which is noted in the reviews about Cefazolin, is the soreness of injections, so the selection of the solvent is very important. If the drug is administered to children, some parents in parallel give Lineks to avoid intestinal disorders.