Fromilid tabs 500mg #14
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Instruction for FromilidYou can buy Fromilid on this pageCompositionFromilid in the form of tablets contains clarithromycin (active ingredient) and a number of auxiliary substances: silicon dioxide anhydrous colloid, propylene gly..
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Instruction for Fromilid
You can buy Fromilid on this page
Composition
Fromilid in the form of tablets contains clarithromycin (active ingredient) and a number of auxiliary substances: silicon dioxide anhydrous colloid, propylene glycol, corn starch, microcrystalline cellulose, talc, pregelatinized corn starch, hydroxypropylmethylcellulose, titanium dioxide, quinoline yellow dye, magnesium stearate.
The Fromilid granules for the preparation of the oral suspension have clarithromycin (active ingredient) as well as a number of auxiliary substances: povidone, carbomer, castor oil, hydroxypropyl methylcellulose phthalate, xanthan gum, talc, citric acid, potassium sorbate, titanium dioxide, sucrose, flavor , colloidal silicon dioxide anhydrous.
Fromilid-Uno, a prolonged-release drug, contains active ingredient clarithromycin, as well as a number of auxiliary constituents: polysorbate 80, talcum, povidone, calcium alginate, magnesium stearate, sodium alginate, hydroxypropylmethylcellulose, lactose monohydrate, quinoline yellow dye, titanium dioxide, anhydrous silicon colloidal dioxide, propylene glycol.
Form of issue
It is produced in the form of granules, which are used to prepare a suspension taken internally. The granules are contained in a 60 ml vial that contains 125 mg in 1 dose (5 ml). The bottle is enclosed in a cardboard box, a dispenser is attached to it.
Tablets Fromilid covers the film membrane. One package contains 14 tablets.
Fromilid-Uno tablets are oval in shape, yellow, covered with a film membrane. The package contains 5, 7 or 14 tablets.
pharmachologic effect
Fromilid is a medicine, an antibacterial agent that belongs to a macrolide group. It has a bacteriostatic effect on various microorganisms by inhibiting protein production in microbial cells. Some agents have a bactericidal effect.
The drug is effective in fighting intracellular infectious agents, Gram-positive gambling negative microorganisms. It also acts on all mycobacteria (except M. tuberculosis), on some anaerobic pathogens.
Pharmacodynamics and pharmacokinetics
Antibiotic Fromilid Uno and Fromilid are well absorbed after oral administration. The active substance quickly enters the tissues that have been affected by inflammation, as well as in body fluids, where a concentration that exceeds 10 times the concentration of the substance in the blood plasma is noted.
The main metabolite is 14-hydroxy-clarithromycin. After ingestion, approximately 20% of the dose is metabolized. If the antibiotic was taken at a dose of 250 mg of clarithromycin, the elimination half-life is 4 hours. If the dose is 500 mg, then the average elimination half-life is 6 hours. In the unmodified form, 20-30% of the substance is eliminated, the rest of its quantity is released as metabolites.
Indications for use
Fromilid Uno and Fromilid is prescribed for the treatment of the following diseases:
infectious diseases of the respiratory tract (bronchitis, tonsillopharyngitis, acute sinusitis, otitis media);
infectious diseases of skin and soft tissues (erysipelas, infections with wounds, boils, carbuncles);
mycobacterial diseases;
in the complex treatment of Helicobacter pylori infection;
preventive measures against people with AIDS.
Contraindications
Do not take the drug in the following cases:
If there is a high sensitivity to clarithromycin, macrolides or other ingredients of the drug.
It is impossible to combine the use of Fromilid with cisapride, terfenadine, pimozide, astemizole.
The drug is contraindicated in severe kidney disease, with porphyria.
Side effects
In most cases, the side effect of the drug is not pronounced, its manifestations quickly disappear.
The following manifestations are possible:
In the functions of the gastrointestinal tract: nausea, diarrhea, vomiting, pain in the abdomen, stomatitis, glossitis, taste change, increased activity of liver enzymes, in rare cases - cholestatic jaundice.
In the functions of the immune system: manifestations of high sensitivity (hives, anaphylactic shock, etc.).
In the functions of the nervous system: headache, dizziness, insomnia, periodic nightmares.
Instructions for use of Fromilid (Method and dosage)
Tablets Fromilid need to swallow whole, drink a small amount of water. Adult patients and children after twelve years take 250 mg twice a day after 12 hours. In the treatment of sinusitis, as well as severe infectious diseases, patients are prescribed a dose of 500 mg twice a day 12 hours later. The course of therapy lasts from 1 to 2 weeks.
When Helicobacter pylori infection is prescribed as part of a complex treatment of 250-500 mg at 12 hours twice a day. Treatment lasts one week.
In the prevention and treatment of diseases that are associated with the bacteria Micobacterium complex avium agent should be taken every 12 hours for 500 mg, the duration of treatment is indicated by the doctor. If there is such a need, the dose may be increased, but more than 2000 mg of the drug can not be taken per day.
For the treatment of children, the dosage of the drug is calculated on the basis that 15 mg of the drug is required for each kilogram of body weight. The daily dose of Fromilid is divided into two doses after 12 hours. The daily allowable dose for children is 1000 mg.
Fromilid 125 suspension is used to treat children. To prepare the suspension, it is necessary to add 42 mg of boiled water into a beaker with granules. Children under 12 years of age are prescribed in a dose of 15 mg each for each kilogram of body weight. The daily dose is divided into two doses in 12 hours. The forroyl 250 suspension is determined, if necessary, with a dispenser. Suspension should be washed with water. A day is allowed not more than 1000 mg of the drug.
Instructions for use Fromilid Uno 500 mg is as follows: the tablets should be swallowed during meals and washed down with a small amount of water. What exactly the dose of the drug should be used, and also how long the treatment should last, is determined individually.
The instruction for Fromilid Uno provides that children after 12 years and adults take 500 mg of the drug once a day, doing this at the same time. In severe infectious diseases, the dosage can be increased to 1000 mg per day. Treatment lasts from 1 to 2 weeks.
Overdose
In case of overdose, those manifestations that are side effects when taking the remedy may be noted. A person can complain about a headache, pain in the abdomen, vomiting. Sometimes confusion is noted. As a treatment, gastric lavage is used, symptomatic treatment is prescribed.
Interaction
When used simultaneously for the treatment of Fromilid and warfarin or other anticoagulants, prothrombin time should be carefully monitored.
Fromilid is not prescribed concomitantly with Pimozide, Terfenadine, Astemizol, Cisapride.
If at the same time with Toromilinum, Tefillinum, Carbamazepine, Midazolam, Tacrolimus, Digoxin, Lovastatin, Triazolam, Phenytoin, Simvastatin, Ciclosporin, and ergot alkaloids, it is necessary to strictly control the concentration of active substances of these agents in the blood.
With concurrent administration of clarithromycin and zidovudine, zidovudine absorption is reduced. Fromilid-Uno is not recommended for treatment with zidovudine.
When combining Fromilid with ritonavir, the serum level of clarithromycin increases significantly, with a marked decrease in 14-hydroxy-clarithromycin.
Under the influence of clarithromycin, the concentration of hormonal constituents of oral contraceptives in the blood does not change.
Storage conditions
Store the medicine in a dry place, at an ambient temperature of not more than 25 ° C. It is necessary to protect the drug from children.
Shelf life: Fromilid and Fromilidide Uno - 3 years.
special instructions
After treatment with Fromilid, the patient may exhibit cross-resistance of microorganisms to other antibiotics belonging to the macrolide group. If a person has minor violations in the work of the kidneys, the dosage of the drug does not change.
At porphyria the agent is not appointed or nominated.
During the treatment with Fromilid, changes in the intestinal microbiocenosis and, as a result, the emergence of microorganisms resistant to clarithromycin are possible. People who have prolonged severe diarrhea during treatment should undergo research and exclude pseudomembranous colitis.
Patients with chronic liver diseases need to carefully and regularly monitor serum enzymes.
The drug does not affect psychomotor reactions during transport management or work with precise mechanisms.
Children
If the age of the patient is less than 12 years, then the treatment is administered with the parentylide suspension for children. For treatment of children under the age of six, the remedy is not recommended, since information about its safety is not enough.
With alcohol
Simultaneous intake of Fromilid and alcohol is not recommended.
In pregnancy and lactation
It is not recommended to use a drug to treat pregnant women. In the first trimester, the use of the drug is contraindicated. If the expected effect of the drug treatment exceeds the possible risks to the fetus and the mother, it is possible to take Frömylid in the second and third trimester.
Clarithromycin enters breast milk, therefore, breastfeeding should be stopped while treating a drug.
Reviews of Fromilid
Among those who underwent a course of treatment with the drug, reviews of the 500 mg of forromide are mostly positive. It is noted that the remedy is effective in combating infectious diseases, as well as the fact that it is prescribed even in emergency situations, when there is no time for additional research and searching for a specific pathogen. The drug has a wide range of effects, so it is effective for many diseases. It is important to take it according to the prescribed scheme and choose the right dosage, both for adults and for children. As a negative point, a very bitter taste of the drug is noted, which in some cases has become an obstacle to treatment, in particular, in pediatric patients.
Reviews for Fromilid Uno 500 mg are also predominantly approving. Adverse events are rare, mainly with the help of a drug that allows you to quickly get the expected effect.