Klacid SR tabs 500mg #14

Klacid SR user manual

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See also - Klacid

Composition

Tablets of Klacid SR contain the active substance: clarithromycin and other components: anhydrous citric acid, lactose, sodium calcium alginate, sodium alginate, povidone K30, talc, magnesium stearate, stearic acid.

Form of issue

Klacid SR 500 mg is available in the form of tablets of yellow color, oval in shape, which covers the film membrane. Tablets of prolonged exposure in blisters for 5, 7, 10 or 14 pieces, in a cardboard box can be placed 1 or 2 blisters.

pharmachologic effect

The active substance clarithromycin is a semisynthetic antibiotic belonging to the macrolide group. It provides an antibacterial effect by interacting with the 50S ribosomal subunit. Thus, the processes of the bacterial protein are suppressed, which show a pronounced sensitivity to this antibiotic.
Due to the homogeneous basis, the tablets are sustained. The active substance is released for a long time during the passage of the drug through the gastrointestinal tract.
Clarithromycin effectively influences both standard laboratory strains of bacteria and those that were isolated during the course of clinical practice in patients. The active substance of the drug Klacid SR actively spreads many gram-positive and gram-negative, aerobic and anaerobic microorganisms.
The substance shows activity against Mycoplasma pneumoniae, Legionella pneumophila, but it does not affect Pseudomonas spp, Enterobacteriaceae.
The main metabolite of clarithromycin is 14-OH-clarithromycin, which is a microbiologically active metabolite. With respect to some microorganisms, it exerts a more pronounced activity than the active substance in the initial state.

Pharmacokinetics and pharmacodynamics

The process of the metabolism of clarithromycin occurs in the liver. The level of bioavailability of the drug is approximately 50%. About 70% of the substance binds to blood serum proteins. In tissue and fluid in the human body, clarithromycin and its 14-OH-metabolite penetrate rapidly. Approximately 40% of clarithromycin is excreted from the body through the kidneys, another 30% through the intestine.

Indications for use

Klacid SR is prescribed for the treatment of ailments, which were provoked by microorganisms demonstrating high sensitivity to the drug. In particular, these are infections of an infectious nature, in which the lower parts (pneumonia, bronchitis) and upper sections (sinusitis, pharyngitis) of the respiratory tract are affected.
Also, the drug is used to treat infectious diseases of soft tissues and skin.
Contraindications
You can not use an antibiotic for treatment if a person has such diseases and conditions:
    high sensitivity to the components of tablets and other drugs from the group of macrolides;
    renal failure in severe form;
    lactose intolerance, glucose-galactose malabsorption, lactose deficiency;
    porphyria;
    age to 18 years.
The simultaneous administration of the antibiotic Klacid SR and the following drugs is not allowed: pimozide, astemizole, terfenadine, cisapride, dihydroergotamine, ergotamine, as well as with oral forms of medications midazolam, Alprazolam, Triazolam.
The drug is administered with caution in case of impaired functioning of the kidneys, liver, or myasthenia gravis. Care must be taken when taking the medications that metabolize in the liver at the same time.

Side effects

Probably the development of the following side effects when treated with this antibiotic:
    Cardiovascular system: in rare cases - ventricular tachycardia, ventricular fibrillation, increased QT interval on the ECG.
    The digestive system: dyspepsia, nausea, abdominal pain, diarrhea, stomatitis, acute pancreatitis, glossitis, candidiasis of the oral cavity, pseudomembranous enterocolitis; there may be violations of the liver, as well as increased activity of liver enzymes.
    Nervous system: dizziness and headaches, insomnia, anxiety, ringing in the ears, convulsions, hallucinations, depressive state, psychotic disorders, disorientation.
    Urinary system: interstitial nephritis.
    The musculoskeletal system: myalgia.
    Organs of the senses: a change in the sense of smell or taste, hearing impairment.
    Manifestations of allergies: urticaria, anaphylactic reactions, pruritus and hyperemia of the skin, rash.
    Laboratory indicators: the increase in the level of creatinine in the blood, thrombocytopenia, hypoglycemia.

Instruction for the use of Klacid SR (Method and Dosage)

Instruction for the use of Klacid SR provides for the taking of tablets orally, whole. It is advisable to take them during meals. In most diseases, adult patients receive 1 tablet 500 mg once a day. If the course of the infection is severe, the doha can be doubled (two tablets once a day).
In most diseases, the period of therapy is 5 to 14 days.

Overdose

When taking large doses of Klacid CP tablets, manifestation of abnormalities in the functioning of the digestive system is possible. Also described are cases of changes in the state of the psyche, hypokalemia and hypoxemia.
For treatment, symptomatic therapy should be used. It should wash the stomach, provide support for vital functions. Hemodialysis does not significantly affect the content of clarithromycin in the blood serum.

Interaction

In view of the high likelihood of developing serious side effects, it is contraindicated simultaneously with clarithromycin to take such drugs: Pimozide, Cisapride, Astemizol, Terfenadine, Dihydroergotamine, Ergotamine.
The level of concentration of clarithromycin in the patient's body is influenced by a number of drugs, while simultaneous treatment with which it may be necessary to change the dose of the drug Klacid SR or the replacement of this drug with other medications. These drugs are Rifabutin, Nevirapine, Efavirenz, Rifapentin, Rifampicin, Fluconazole, Ritonavir.
At simultaneous treatment with clarithromycin and drugs Quinidine or Dizopiramid, pirouette tachycardia can develop.
With caution Klacid SR is prescribed to people who receive drugs that are primarily metabolized by CYP3A isoenzymes. In this case, there may be an increase in side effects.
Clarithromycin promotes an increase in the concentrations of HMG-CoA reductase inhibitors (Simvastatin, Lovastatin).
When taking Clarithromycin and oral anticoagulants, the effect of the latter may be enhanced.
With the simultaneous treatment with Clarithromycin, Tadalafil, Vardenafil or Sildenafil, a reduction in the doses of these drugs may be required. Dosage of tolterodine may also be required.
Simultaneous treatment can lead to an increase in the concentration of carbamazepine or theophylline in the bloodstream.
Do not practice simultaneous oral administration of Midazolam and clarithromycin.
There may be an increase in the effects of colchicine, especially in the elderly and in patients suffering from kidney failure. Such people are more likely to be poisoned with colchicine. The action of digoxin can also be enhanced with simultaneous administration with this antibiotic. It is important to carefully monitor the level of digoxin in the blood.
There is a bi-directional effect of Clarithromycin and preparations Itraconazole, Atazanavir, Saquinavir. In some cases, dosage adjustment may be required.
Simultaneous treatment with verapamil and clarithromycin can trigger the manifestation of arterial hypotension, bradyarrhythmia.

Storage conditions

Antibiotic should be protected from children, stored at a temperature of no higher than 30 ° C.
Shelf life - 5 years.

special instructions

Strains of staphylococci, which show resistance to oxacillin and methicillin, also demonstrate resistance to clarithromycin.
With prolonged antibiotic treatment, the appearance of colonies of non-susceptible fungi and bacteria can be noted.
During the treatment with antibiotics, the patient may experience pseudomembranous colitis, either mildly or in severe form. Cases of pseudomembranous colitis occurred two months after the end of antibiotic treatment.

With alcohol

It is impossible to combine Klacid SR and alcohol, as this can lead to the appearance of pronounced side effects.

Children

Klacid SR is not used for treatment of children and adolescents.

In pregnancy and lactation

There is insufficient information about the treatment of pregnant women and mothers with clarithromycin during lactation. In pregnancy, an antibiotic can only be used if the expected benefit is higher than the potential risk. If a woman becomes pregnant during the treatment with the drug, it must be warned about the possible risk to the fetus. In the period of breastfeeding, the treatment of Klacid SR with pills is not practiced.

Reviews about Klacid SR

Reviews for Klacid SR 500 mg in the network are diverse. Patients note that the antibiotic quickly alleviates the symptoms of severe infectious diseases, accelerates recovery. But those to whom this drug is not approached, note that it provokes the development of unpleasant side effects. To get the expected results, the antibiotic for treatment should be selected by the doctor after the study.