Klion-D 100 #10

Klion-D 100 instruction

You can buy Klion-D 100 on this page

Composition

One suppository contains 0.1 g of active ingredient metronidazole + miconazole nitrate 0.1 g + excipients (silicon dioxide, povidone, tartaric acid, sodium lauryl sulfate, magnesium stearate, sodium hydrogen carbonate, carboxymethyl sodium, hypromellose, lactose, crospovidone, starch) .

Form of issue

Vaginal suppositorys are white in strips of 10 suppositorys, in cardboard packages of 1 strip.

pharmachologic effect

Antibacterial, antiprotozoal and antifungal agent used in gynecology.

Pharmacodynamics and pharmacokinetics

The effect of the drug is due to the complex effect on the microflora of the vagina, its constituent components.
Miconazole is an antifungal agent that destroys dermatophytes and yeast fungi, but does not violate pH and does not destroy a healthy microflora in the vagina. The substance directly affects the synthesis of lipid components in the membrane of the fungus, thereby destroying it. Does not penetrate into the blood and is not found in the kidneys and products of the excretory organs, 90% remains in the vagina. The maximum concentration is after 8 hours.
Metronidazole is an antibiotic. It inhibits the synthesis of RNA and DNA of harmful bacteria by reducing the 5-nitro group by transport proteins inside the cell. After entering the vagina, it penetrates into the blood. Its maximum concentration in the blood (half of the administered dose) can be detected after 9 hours.

Indications for use

What is the purpose of the Klion-D 100?

    from thrush;
    for the treatment of vaginitis, which were caused by the bacteria Trichomonas spp. and fungus Candida spp.

Contraindications

The medicine can not be used in the first trimester of pregnancy and breastfeeding and for children.
Also, the use of the drug for patients with drug allergy to the components of the drug, with liver diseases, CNS and leukopenia is excluded.

Side effects

    discomfort, burning and itching on the mucosa;
    vomiting, constipation or diarrhea, nausea, metallic taste in the mouth;
    dizziness, leukocytosis and headache;
    urine can acquire a reddish-brown tint, there will be rashes on the skin.

Instructions for use Klion-D 100 (Method and dosage)

Duration of admission and dosage of the drug should be prescribed by a doctor, depending on the course and extent of the disease.
According to the instructions for the suppository Klion-D 100, One suppository is administered at night, 10 days. Before use, slightly moistened with water. As a rule, in addition appoint tablets Klion.

Overdose

Symptoms of overdose are nausea, vomiting and other increased manifestations of side effects. When the drug gets into the digestive system, it is necessary to wash the stomach, receive enterosorbents and hemodialysis.

Interaction

The drug is not compatible with ethanol, disulfiram, nondepolarizing muscle relaxants, cimetidine, lithium preparations.
At simultaneous reception of indirect anticoagulants, it is necessary to supervise in addition a prothrombin index.
The effectiveness of metronidazole is reduced when combined with phenobarbital and phenytoin.

Storage conditions

In a dark, cool, sheltered from the children's place, the temperature regime is up to 30 degrees.
Shelf life - 5 years.

special instructions

The use of suppositories during a month should be agreed with the attending physician. Usually during menstruation, you should take a break and continue after the end of menstruation.
What is the difference between Klion and Klion-D 100?
Klione tablets contain metronidazole and have a wider range of uses. Usually, in order to combat trichomoniasis, oral intake of some tablets is not enough, from which the Klion-D 100 suppositories are appointed.

With alcohol

Does not blend.

In pregnancy and lactation

Klion D during pregnancy in the first trimester is contraindicated for use. Sometimes prescribe suppositorys during pregnancy in the 2nd and 3rd trimester, under the supervision of a doctor. Due to the fact that a significant part of metronidazole is excreted in breast milk, breast-feeding should be discontinued.

Reviews about Klion-D 100

Feedback on the forums: Overall good. Many used Klion-D 100 from thrush and were satisfied with the result. Some women complain of a strong manifestation of side effects. The drug is quite effective not only from thrush, but also from other types of vaginitis.
Reviews during pregnancy: Despite the fact that the use of the drug during pregnancy is not recommended, women are often prescribed suppositorys. Reviews for suppositorys Klion-D 100 divided, some women well tolerated the medication and this did not affect their children. Many experienced severe burning, itching, pain in the abdomen and stopped taking the drug on their own.