Metromicon-Neo supp 500mg+100mg #14

Instruction for Metromicon-Neo

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Composition

White vaginal suppositories (supposed yellowish tinge) in the form of a torpedo contain 500 mg of active substance metronidazole and 100 mg of miconazole.
Additional components: semisynthetic production glycerides, necessary for obtaining a suppository weighing 2000 mg.

Form of issue

Torpedo-like suppositories for vaginal application with a funnel-shaped depression and an air rod are packed in 7 pieces in special blisters.
In a pack of cardboard is the instruction from the manufacturer and 2 contour blisters with suppositories.

pharmachologic effect

Antimicrobial, antiprotozoal and antifungal. Active ingredient Metronidazole has a bactericidal effect and refers to 5-nitroimidazoles. Is able to interact with deoxyribonucleic acid. The mechanism of action is based on the reduction of the 5-nitro group of metronidazole at the biochemical level by transport intracellular proteins, proteins of the simplest and anaerobic bacteria.
After the reduction process, the 5-nitro group interacts with the deoxyribonucleic acid of the microbial cell, suppressing the synthesis of nucleic acids, which causes the death of the microorganism.
Candlesticks Metromicon-Neo fatalities affect the gardnerelly (facultative anaerobic), gram-positive bacteria, trichomonads, gram-negative microorganisms. Anaerobes show resistance to metronidazole, but with respect to mixed flora in combination with antibiotics, synergism and suppression of the activity of conventional aerobes are manifested.
The second component of miconazole is an azole derivative and exhibits antimycotic activity. Intravaginal application inhibits the vital activity of Candida albicans. By inhibiting the biological synthesis of ergosterol by plasma-membranes and membranes of the fungal cell, disturbance of cell wall permeability and lipid composition, fungistatic and fungicidal effects are achieved.

Pharmacodynamics and pharmacokinetics

The biological availability of the active component of Metronidazole after intravaginal application is 20%.
After metabolism, active hydroxyl metabolites are formed in the hepatic system. 20% of the administered dose is excreted in its original form with urine.
The half-life is 6-11 hours. The second active component of miconazole in plasma is not determined after intravaginal administration.

Indications for use

Suppositories Metromicon-Neo is prescribed for vaginal infectious lesions:
    bacterial vaginosis;
    Vulvovaginitis caused by Trichomonas;
    vaginal candidiasis;
    mixed infection of the genitals;
    Trichomonas vaginitis.

Contraindications

    virginity;
    breast-feeding;
    individual hypersensitivity;
    pregnancy - I trimester.

Relative contraindications:

    pregnancy - II-III trimesters;
    diabetes;
    porphyria;
    microcirculatory disorders;
    diseases of the nervous system (central and peripheral departments);
    pathology of hematopoiesis.

Side effects

Local reactions:

    swelling of the vaginal mucosa;
    itching;
    burning;
    irritation of the mucous membranes.
On the first day of therapy with vaginitis (or by the third day), irritation and inflammation of the vaginal mucosa may increase.
Negative symptomatology passes by itself at the end of the course.

The digestive tract:

    loss of appetite;
    the taste of metal in the mouth;
    cramping in epigastrium;
    stomach ache;
    vomiting;
    diarrheal syndrome;
    constipation;
    nausea.

Nervous system:

    convulsive syndrome;
    psychoemotional disorders;
    ataxia and other motor disorders;
    headache;
    dizziness.

Other reactions:

    hives;
    leukopenia;
    rashes on the skin.

Metromicon-Neo suppositories, instruction manual (Method and dosage)

Torpedo-like suppositories are administered intravaginally. With the help of scissors cut the contour wrap, release the suppository and insert into the vagina deeply.
Instructions for candles Metromicon-Neo with vaginosis of bacterial origin: at night 1 suppository. Course - 7 days.
In chronic vaginitis, therapy is carried out for 2 weeks, suppositories are administered before bedtime.
With vaginitis with a frequently recurrent course, it is recommended that in the morning and in the evening, 1 candle be administered for 14 days.

Overdose

Low absorption of active ingredients eliminates overdose if recommended treatment regimens are followed.
The possible clinical picture consists of the following negative symptoms:
    staining the urine in a dark color;
    convulsions;
    paresthesia;
    pain in epigastrium;
    vomiting;
    nausea;
    peripheral neuropathy;
    skin rashes;
    ataxia;
    dizziness;
    leukopenia.
If ingested, adequate post-ordromic therapy is performed.

Interaction

Metronidazole enters the systemic circulation and may enter into pharmacological interaction with other medicines. Metromicon-Neo enhances the effects of anticoagulant drugs of indirect effect.
In the treatment with disulfiram, abnormalities can be detected from the work of the nervous system in the form of various psychic reactions. It is recommended to maintain a 2-week break between receptions.
Simultaneous therapy with phenytoin leads to an increase in the concentration of the latter and a decrease in the level of Metronidazole in the blood. The drug enhances the toxicity of Li preparations. Phenobarbital is able to reduce the level of metronidazole in the blood.
The reverse effect is recorded against the background of cimetidine treatment. Ethanol provokes the development of disulfiram-like negative reactions. Metromicon-Neo inhibits the metabolism of Terfenadine and Astemizole, increases their concentration in the plasma.

Storage conditions

Observance of a temperature mode of 15-25 degrees allows to keep efficiency of a medicine.
Shelf life - 3 years.

special instructions

Treatment with a combined drug requires complete abstinence from sexual intercourse. Parallel treatment partner can prevent re-infection. When Vaginitis Trichomonas genesis partner is recommended to take Metronidazole orally.
It is unacceptable to drink alcohol containing drinks. Condoms from latex, rubber and contraceptive diaphragms are not recommended for use during treatment with Metronomicon-Neo.
With the progression of irritation in the vagina, the treatment is stopped. Oral or other use of suppositories is not permissible, except as intravaginal. Reception of metronidazole inside against the background of the introduction of suppositories requires control over all indicators of the state of the blood because of the high risk of developing leukopenia.

Children

In pediatric practice, Metromicon-Neo is not used.

Reviews of Metromicon-Neo

Doctors-gynecologists quite often prescribe medication as part of complex therapy of the majority of gynecological diseases of infectious genesis. Reviews about the candles of Metromicon-Neo from the side of medical workers and patients are positive: the drug is convenient to use, well tolerated, quickly removes the negative and unpleasant symptoms of vaginitis and candidiasis, relieving itching, burning and discomfort in the vagina.
Combined composition of the drug significantly expands the range of its use: fungal, protozoal and microbial infections of the vagina. The advantage of the drug is an acceptable price in comparison with similar drugs.
Medication can be used during pregnancy according to the indications. At the forums, nursing mothers note that during the treatment the milk becomes bitter, therefore it is recommended to interrupt lactation for the period of the complete course of treatment.