Zanocin tabs 200mg #10

User manual for Zanocin

Reed more and buy Zanocin on this page

Composition

In 1 tablet 200 mg ofloxacin.
Crospovidone, sodium hydrogencarbonate, hypromellose, sodium alginate, xanthan gum, magnesium stearate, lactose monohydrate, carbopol, silicon dioxide, - as auxiliary substances.

Form of issue

The coated tablets are 200 mg.

pharmachologic effect

Antibacterial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug is a group of fluoroquinolones (monofluoroquinolones of the 2nd generation), which has a wide spectrum of action. Highly active against gram-negative and some gram-positive microorganisms.
It is moderately sensitive to Streptococcuspneumoniae, Enterococcusfaecalis, Pseudomonasspp., But anaerobic bacteria are not sensitive. Ofloxacin is resistant to the effects of β-lactamases.

Pharmacokinetics

Quickly absorbed from the digestive tract. Eating somewhat slows down the rate of absorption. Cmax in the blood is determined after 2 hours. It is widely distributed in the organs of the urinary and reproductive system, lungs, gall bladder, ENT organs, skin and bones. For 24 hours 80% of the active substance is unchanged in the urine, a small part is excreted with feces. Half-life 6 h.

Indications for use

Infections:
    ENT organs (otitis, sinusitis, tonsillitis);
    respiratory tract (infected bronchiectasis, pleurisy, empyema, abscess, non-hospital pneumonia);
    bones, skin and soft tissues;
    genitourinary system (cystitis, urethritis, pyelonephritis, prostatitis, gonorrhea, epididymitis, mixed urethral infections);
    inflammation of the pelvic organs;
    typhoid fever, shigellosis, salmonellosis.

Contraindications

    hypersensitivity to the active substance;
    organic lesions of the central nervous system;
    pregnancy;
    lactation;
    age to 18 years.
In patients with impaired renal and hepatic function, the drug is used with caution. During the treatment, blood sugar, peripheral blood, kidney and liver function are monitored.

Side effects

    nausea, vomiting, upset stomach, abdominal pain, decreased appetite, bloating, in rare cases - hepatitis, liver necrosis, pseudomembranous colitis and intestinal bleeding;
    dizziness, insomnia or drowsiness, irritability, rarely - convulsions, depression, hallucinations, anxious dreams, suicidal thoughts, phobias, peripheral neuropathy, impaired coordination and speech;
    rash, itching, Quincke's edema, urticaria, anaphylactic shock, allergic pneumonitis, conjunctivitis, erythema nodosum, epidermal necrolysis;
    vaginitis, dysmenorrhea, metrorrhagia, vaginal discharge and itching, vaginal candidiasis;
    very rarely observed: edema, arterial hypertension or hypotension, tachycardia, urinary retention, polyuria or anuria, arthralgia, tendonitis, myasthenia exacerbation, hyper- or hypoglycemia, bronchospasm, stridor, epistaxis, anemia, agranulocytosis and leukopenia.

Zanocin, instructions for use (Method and dosage)

Tablets are taken inside whole (do not break, do not chew) after eating, squeezed with water.
The dose depends on the severity of the disease, age, body weight, kidney function and is determined by the doctor. Most often, the dose is 400 mg / day, divided into 2 divided doses (or in one morning), and the course of treatment is 7-10 days. In severe infections, therapy is prolonged.
Zanocin OD is a 400 mg and 800 mg sustained-release film-coated tablets that are taken once a day and are equivalent in therapeutic effect to 2 tablets of 200 mg and 400 mg taken twice a day. With some diseases, a daily dose of 800 mg and it is more appropriate to take Zanocin OD.

Overdose

Overdose is manifested by symptoms: dizziness, confusion, confusion, disorientation in space, drowsiness, vomiting.
Treatment is symptomatic, begins with the gastric lavage and maintenance of water-elitrolith balance.

Interaction

The absorption of quinolones decreases and their concentration in the blood decreases with simultaneous application with sucralfate, antacids, iron preparations, multivitamins with zinc. Reception of these drugs is carried out on time with an interval of 2 hours.
With the joint appointment of ofloxacin and NSAIDs, there is a risk of seizures.
Ofloksatsin increases the concentration in the blood of Teofillin, which is associated with increased adverse reactions of the latter.
With simultaneous use with aminoglycosides, beta-lactam antibiotics, Metronidazole, the effectiveness of the action is summarized.

Terms of sale

To buy Zanocin you don't need a prescription.

Storage conditions

Temperature up to 25С.
Shelf life - 3 years.

Reviews about Zanocin

Quinolones are widely used in the treatment of gynecological and urological diseases, as evidenced by the reviews. Many patients were prescribed this drug for the treatment of salpingo-oophoritis, perimetritis, metroendometritis in outpatient settings. Treatment was highly effective and rational, because according to gynecologists, ofloxacin is the most effective drug for treating these diseases. The treatment was well tolerated. Only a few had minor nausea, anorexia, and diarrhea. There were manifestations of photosensitization during treatment in the summer.
Ofloxacin is excreted in urine by the kidneys, which makes it possible to successfully treat urological diseases of an inflammatory nature. As early as 5-7 days, bacteriuria disappeared, overall well-being improved. Treatment took place at a low level of side effects.
Norbaktin and Zanocin are effective against pseudomonads and E. coli, which makes it possible to use these drugs to treat purulent-inflammatory diseases. In addition to a wide spectrum of bactericidal action, Zanocin has an immunomodulating effect, which makes it the drug of choice in the treatment of diseases in patients with weakened immunity (AIDS patients, oncological patients).