Argosulfan cream 2% 40gr

Argosulfan user manual

You can buy Argosulfan on this page

Composition

In 1 g of cream contains 20 mg of silver salt of sulfatiazole. Auxiliary components of the base: dihydrogen phosphate and sodium lauryl sulfate, methylhydroxybenzoate, glycerin, water for injection, propylhydroxybenzoate, potassium hydrogenphosphate.

Form of issue

Argosulfan is available as a white cream with a pink tint in tubes of 15 and 40 grams in packs of cardboard.

pharmachologic effect

Ointment Argosulfan has an antimicrobial effect, contributing to the early healing of wounds of various etiologies (purulent lesions, trophic ulcer changes, burns). The drug cures pain symptoms, prevents infection of wounds, shortens the healing time. In some cases, against the background of the use of the drug, there is no need for transplantation of skin flaps.
Argosulfan cream contains in its composition one of the sulfonamides - sulfatiazole, which has a pronounced antimicrobial effect, acting on microorganisms bacteriostatically. The spectrum of action of the active component is gram-positive microbes and gram-negative flora. The main mechanism of antibacterial action is directed at suppressing the growth and growth of microorganisms by suppressing the activity of dihydropteroate synthetase and competitive antagonism with PABA. As a result of the reaction, the process of synthesizing dihydrofolic acid and its main metabolite of tetrahydrofolic acid, which is vital for the synthesis of pyrimidines and purines of the microorganism, is changing.
Thanks to silver ions, the antimicrobial effect of sulfanilamide is enhanced by binding to the DNA of the bacterium and subsequent inhibition of growth and division of the microbial cell. In addition, silver ions suppress the sensitizing activity of sulfanilamide.
The optimal pH and hydrophilic base of the cream promote moistening of the wound, acceleration of healing, anesthesia.

Pharmacodynamics and pharmacokinetics

The silver salt of sulfatiazole has a weakly expressed solubility, so that the concentration of the main active ingredient on the wound surface is maintained at the optimum, necessary level. The drug has no toxic effect due to minimal resorption. A small proportion of silver salt enters the systemic circulation, and then is acetylated by the hepatic system. The larger the area of ​​application of the cream, the higher the absorption index of sulfatiazole.

Indications for use

The medication is used in the therapy of patients with damaged skin:
    burns;
    frostbite (all degrees);
    pressure sores;
    trophic ulcerative lesions;
    household trauma (cut, abrasion);
    contact dermatitis;
    purulent-infected wounds;
    eczema;
    microbial dermatitis;
    staphyloderma;
    streptoderma.

Contraindications

    shock state with extensive burns;
    individual hypersensitivity;
    congenital form of insufficiency of glucose-6-phosphate dehydrogenase;
    lactation.
The drug is not prescribed for children until 2 months of life, premature babies because of the high risk of developing the nuclear form of jaundice.

Side effects

The cream does not change the color of the skin. Long-term therapy can provoke systemic reactions (desquamative dermatitis, changes in the work of the hematopoiesis). Allergic responses are rarely recorded. The medication is well tolerated if you follow the doctor's advice and follow the instructions. In comparison with preparations of a similar action, the least frequent adverse reaction is given by Argosulfan ointment.

Instructions for use (Method and dosage)

The medication is not intended for oral administration, only external use is allowed. The cream can be applied to open wounds, it is allowed to use a special occlusive dressing. The drug is applied to the cleansed skin, observing the rules of asepsis, antiseptics. In the presence of exudate, pre-treatment of the skin with a solution of boric acid 3%, or a solution of chlorhexidine 0.1% is recommended.
Instruction on Argosulfan: the medication is applied with a thin layer 2-3 mm thick until the wound surface is completely covered or ready for skin grafting. Every day it is recommended to hold 2-3 procedures. Daily you can apply no more than 25 g of ointment. Duration of the course treatment is 2 months. With prolonged, continuous therapy, mandatory control over the functional parameters of the liver and kidney system is required.

Overdose

There is no reliable data.

Interaction

In one area of ​​the skin, you can not simultaneously use Argosulfan and other medications. The effectiveness of silver sulfatiazole is reduced when treated with procaine, folic acid preparations and its structural substitutes.

Terms of sale

Without prescription.

Storage conditions

Away from the light, sunlight. The preferred temperature regime is 5-15 degrees Celsius. Store in a dry place.
Shelf life - 2 years.

During pregnancy (and lactation)

During pregnancy, Argosulfan can be used only in cases of acute need, for example, if the skin is damaged more than 20%. It is recommended to stop breastfeeding because of partial absorption of the medication.

Reviews about Argosulfan

In medical practice, the cream has established itself as an excellent tool in the treatment of large area burns. Thematic forums and medical portals, where ordinary patients share their impressions, contain only positive reviews about Argosulfan. Young mothers also leave their feedback about ointments, and point to its good tolerability by young children, high efficiency in the treatment of abrasions, cuts and wounds.