Effezel gel 1mg/gr + 25mg/gr 30gr

Effezel instruction for use

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Composition

1 gram of gel contains 1 mg of adapalene, 25 mg of benzoyl peroxide and auxiliary components: poloxamer, glycerol, polysorbate, isohexadecane, simulgel, water, docusate sodium, sorbitan oleate, disodium edetate.

Form of issue

Effezel is produced in the form of an opaque gel with a slightly yellow hue in laminated plastic tubes. Capacity 2, 15, 30, 45, 60, 90 g. Each tube is packed in a pack of cardboard.

pharmachologic effect

A medication for acne treatment. The components of the drug potentiate the action of each other.
Adapalene is a stable derivative of naphthoic acid with a retinoid-like effect. The active component has a pronounced anti-inflammatory effect and modulates the processes of cellular keratinization and differentiation. The principle of action is based on the combination of adapalene and specific nuclear receptors of retinoic acid. Modern medicine suggests that with local effects adapalene is able to normalize the differentiation of cellular epithelial follicles, which leads to a decrease in the formation of micro-mediodons. In vitro, the substance inhibits the metabolism of arachidonic acid and all inflammatory mediators. Thus, adapalene is able to reduce the severity of the inflammatory component of acne eruptions.
Benzoyl peroxide has an antimicrobial effect and acts directly on the sebaceous hair follicle with acne. The component has a keratolytic, sebostatic and exfoliating effect. Benzoyl limits the production of sebum, which plays an active role in the formation of acne eruptions.

Pharmacodynamics and pharmacokinetics

Adapalene does not have systemic influence. Benzoyl poorly penetrates through the skin and is quickly transformed to benzoic acid.

Indications for use

Gel Effezel is prescribed for acne, accompanied by pustules, comedones and papules.

Contraindications

In children under 12 years, the safety of the drug has not been investigated. The drug is not prescribed for allergic responses and individual hypersensitivity.

Side effects

    contact dermatitis;
    dry skin;
    allergic dermatitis;
    sunburn;
    itching;
    burning.
The above-described negative symptoms go away after 7 days.

Instruction for Effezel (Method and dosage)

It is recommended to apply ointment before bedtime on a dry, clean skin with a thin layer, avoiding contact with the mucous lips and eyes. A noticeable therapeutic effect is recorded after 1-4 weeks of regular use. In the absence of effect and the development of pronounced negative reactions, it is recommended to cancel Effessel gel independently. The instructions for use contain an indication of the possibility of additional application of moisturizers, which do not have a comedogenic effect.

Overdose

If swallowed, post-prandial therapy is performed.

Interaction

The use of drying, exfoliating and irritating agents is recommended to limit for the entire treatment period. Unacceptable simultaneous treatment with other retinoids. Adapalene is not able to be absorbed into the systemic circulation and come in contact with other medicinal products.

Storage conditions

Limit the tolerance of young children. Temperature regime - up to 30 degrees.

Shelf life

The opened tube can be stored for no more than six months. Shelf life of the sealed tube is 2 years.

special instructions

Do not apply to the eczematous altered skin. Avoid prolonged contact with mucous membranes, nostrils, mouth and eyes. It is not recommended to apply the medicine in the presence of abrasions and cuts on the skin. The gel contains propylene glycol, which in itself is capable of exerting an irritating effect. With the development of an allergic response, the medicine is canceled.
It is recommended to limit the influence of ultraviolet and sunlight on the skin. The gel can discolour colored fabrics and hair, which is important to consider when using the drug.

In pregnancy and lactation

There is no reliable information about the safety of benzoyl peroxide and adapalene in women during pregnancy. The toxic effect of adapalene and benzoyl on the reproductive system was recorded when animals were fed the above components orally.
When pregnancy occurs during therapy with Effezel, an independent gel cancellation is recommended. The medication can be applied while breastfeeding, avoiding direct contact between the drug and the newborn baby.

Reviews of Effezel

Reviews about the gel Effezel, found on the Internet, mostly positive. Participants in the thematic forums report that the drug is actively used for acne. Reviews for Effezel indicate the high effectiveness of the drug in the treatment of acne eruptions and acne in people of different age groups. Rarely manifest negative reactions in the form of irritation and flaking.