Hexoral tabs #16

Hexoral tabs instruction

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Composition

Hexoral tabs contains active ingredients of chlorhexidine dihydrochloride and benzocaine, as well as auxiliary components: peppermint oil, isomalt, menthol, aspartame, thymol, water.

Form of issue

Tablets of Hexoral Tabs are produced for resorption. These are biconvex, round, opaque tablets, the surface of which is rough. The shade can be from yellowish-gray to yellow-white. Staining can be uneven, irregular edges and the presence of air bubbles are allowed. White coating may appear. Contained in a blister for 10 pcs., In a package of cardboard - 2 blisters.

pharmachologic effect

Hexoral tabs Classic contains two active ingredients, so it has a double effect. Its antibacterial effect is due to the presence of chlorhexidine in the drug. Local anesthetic benzocaine reduces pain symptoms.
Chlorhexidine provides a wide range of antibacterial effects against gram-negative and gram-positive bacteria. The substance destroys the cytoplasmic membrane of the bacterial cell. Its low efficiency with respect to dermatophytes, yeast fungi, mycobacteria, and also certain species of Pseudomonas and Proteus is noted.
Chlorhexidine is most effective in a slightly alkaline or neutral environment. Less active in an acidic environment.
In the process of resorption of tablets with chlorhexidine, the number of bacteria in the saliva is markedly reduced. If chlorhexidine is used for several months, its effectiveness decreases due to a decrease in the sensitivity of bacteria.
Benzocaine is a local anesthetic, it reduces pain in the oral cavity and pharynx for an extended period of time. The substance penetrates through the lipophilic areas of the cell membrane and affects the peripheral pain receptors of the skin and mucous membranes, skin and skin.

Pharmacokinetics and pharmacodynamics

There is no information on the absorption of chlorhexidine through the oral mucosa. In the saliva, the substance can survive up to 8 hours.
Benzocaine produces an anesthetic effect after 15-30 seconds after application, it gradually decreases as the substance is diluted with saliva (this occurs for 5-10 minutes). In water, little is dissolved, so it is absorbed slowly. It is cleaved by esterase in the liver and blood plasma. As a consequence, the formation of para-aminobenzoic acid and ethyl alcohol, metabolized to acetylcoenzyme A. It is excreted through the kidneys.

Indications for use

Tablets Hexoral tabs are used in the following cases:
    with diseases of the throat or oral cavity, which have an infectious-inflammatory character;
    with angina, pharyngitis, other inflammatory diseases of the pharynx;
    with gingivitis;
    with stomatitis.

Contraindications

Do not apply Hexoral tabs in such cases:
    with a high sensitivity to the ingredients of drugs;
    if there are wounds or ulcers in the mouth or throat;
    in the case of a low concentration of cholinesterase in plasma;
    children up to 4 years.
Carefully applied the drug in the presence of desquamative and erosive lesions of the oral mucosa.

Side effects

If you use Hexoral tabs for an extended period of time, there may be a brief disruption of taste, as well as numbness of the tongue. Possible the appearance of reversible discoloration of the tongue and teeth.
If a patient has an increased sensitivity to benzocaine, allergic reactions can rarely be noted until the development of anaphylactic shock.
Benzocaine can provoke methemoglobinemia in children.

Hexoral Tabs, instructions for use (Method and dosage)

Instructions for use Hexoral tabs provides that the drug is applied by slow resorption in the mouth until the tablet completely dissolves.
Take the pill immediately after the first signs of the disease. Reception continues for several days after the symptoms have disappeared.
Adults and adolescents after 12 years of age should resolve 1 tablet every 1-2 hours, but you can not take more than 8 tablets per day.
Patients aged 4 to 12 years can take no more than 4 tablets per day.
Before use, consult a specialist.

Overdose

If the patient takes the drug according to the instructions, then an overdose is impossible because chlorhexidine is almost not absorbed into the blood.
Benzocaine is absorbed insignificantly. Overdose of benzocaine occurs when the product is used improperly. In this case, there may be a toxic effect on the central nervous system, in which there is vomiting, convulsions, tremor, and then the central nervous system is depressed. At high toxic concentrations, bradycardia, blockade of AV conduction and cardiac arrest can occur. It should be borne in mind that benzocaine can provoke the manifestation of methaemoglobinaemia, especially in children. This condition accompanies suffocation and cyanosis.
In case of overdose symptoms, induction of vomiting and gastric lavage are necessary. Activated charcoal may also be prescribed.
In the case of convulsions, Diazepam or high-speed barbiturates are prescribed. If hypoxia and anoxia develop, artificial respiration and oxygen support are performed. When cardiac arrest, heart massage is practiced. In the case of methemoglobinemia, intravenously, up to 50 ml of 1% methylene blue solution is used.

Interaction

In view of the formation of the metabolite of benzocaine-4-aminobenzoic acid, the antibacterial activity of aminosalicylates and sulfonamides decreases.
The effect of chlorhexidine decreases with the simultaneous administration of polysorbate 80, sucrose, insoluble magnesium salts, calcium and zinc.

Terms of sale

It is sold without a prescription.

Storage conditions

Store Hexoral Tabs at t no higher than 25 ° C, protected from access by children.
Shelf life - 3 years.

special instructions

It should be borne in mind that benzocaine can provoke methemoglobinemia, in which the patient can change the color of the skin, nails, lips to pale, blue or gray shade. Also develops shortness of breath, severe fatigue, tachycardia. The risk of manifesting this condition in children is higher. Therefore, it is necessary to use this drug in children under the supervision of adults.
As part of the drug, there is aspartame, a derivative of phenylalanine, which is dangerous for people suffering from phenylketonuria.
It is necessary to use caution in children and people with swallowing disorders and aspiration because of the danger of suffocation.
Does not affect the ability to drive transport and perform those actions that require increased concentration of attention.
Diabetics should take into account that one tablet corresponds to 0.1 XE.

Children

Hexoral tabs is not used to treat children under 4 years old.

In pregnancy and lactation

There is no experience using the use of Hexoral Tabs in pregnant women, as well as during lactation. It can be used only if the potential benefit exceeds the risk of adverse effects on the fetus or on the child.

Reviews of Hexoral Tabs

Basically, users leave positive feedback. Those who used this drug, note that the greatest effect of the pill is produced if applied at the first symptoms of the disease. In the reviews we are talking about the effectiveness of tablets with sore throats, in particular, it is noted that they quickly relieve pain. Also write about the pleasant taste of tablets. Information on adverse side effects is very rare.