Grammidin spray 0.06mg + 0.1mg/dose 112doses

Grammidin spray instruction for use

Reed more and buy Grammidin spray on this page

pharmachologic effect

Pharmacotherapeutic group:
Antibiotic + antiseptic
АТХ:
R.02.A Drugs for the treatment of throat diseases

Pharmacodynamics

Combined drug for the treatment of infectious and inflammatory diseases of the throat and oral cavity.
The preparation includes antimicrobial agent gramicidin C and an antiseptic agent - cetylpyridinium chloride. The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which violates its stability and causes death. Gramicidin C has antibacterial action against a wide range of gram-positive and gram-negative microorganisms. Cetylpyridinium chloride refers to antiseptic agents, suppresses the growth and reproduction of infectious agents of the oral cavity and throat. The drug has an antimicrobial effect, reduces inflammation, softens discomfort in the throat, facilitates swallowing.

Pharmacokinetics

Grammidin spray is topical. According to the data of preclinical studies of pharmacokinetics, there is practically no absorption.

Indications

Infectious and inflammatory diseases of the mouth and throat: pharyngitis, tonsillitis, periodontitis, gingivitis, stomatitis.

Contraindications for Grammidin spray

    Hypersensitivity to gramicidin C, cetylpyridinium chloride and other components of Grammidin spray;
    pregnancy (I trimester);
    lactation period;
    children's age till 18 years.

Carefully

Pregnancy (II-III trimester).

Application Grammidin spray in pregnancy and lactation

Before using Grammidin spray, if you are pregnant or think that you might be pregnant, or plan a pregnancy, you should consult a doctor. Adequate controlled studies of the use of the drug in pregnancy have not been conducted. The use of the drug in the first trimester of pregnancy is contraindicated. The use of the drug in the II-III trimester of pregnancy is possible if the potential benefit to the mother exceeds the possible risk to the fetus.
There is no data on the penetration of the components of the drug into breast milk. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

special instructions for Grammidin spray

Do not use the drug in the presence of open wounds in the mouth, because cetylpyridinium chloride slows the healing of wounds.
The drug contains ethanol. In the maximum single dose of the drug, the ethanol content is up to 0.08 g.
Effect on the ability to drive transp. cf. and fur:
The drug does not affect the ability to perform potentially dangerous activities requiring special attention and speed of reactions (driving and other vehicles, working with moving mechanisms, dispatcher and operator work, etc.).

Composition of Grammidin spray

One dose of the drug contains:
Active substances:
Gramicidin C dihydrochloride - 0.0638 mg (in terms of gramicidin C - 0.06 mg)
Cetylpyridinium chloride 0.10 mg
Excipients:
Ethanol 96% - 19.00 mg
Sucralose 0.20 mg
Glycerol 33.20 mg
Flavoring mint - 0,82 mg
Citric acid monohydrate - 0.058 mg
Sodium citrate 0.022 mg
Polysorbate 80 0.40 mg
Methylparahydroxybenzoag (methylparaben) 0.184 mg
Propyl parahydroxybenzoate (propylparaben) 0.02 mg
Purified water - up to 0.2 ml.

Dosing and Administration

Locally, by spraying on the mucous membrane of the mouth and throat. It is used after eating.
Dosage for adults: 4 injections per application 3 times a day for 7 days. Immediately after using Grammidin spray should refrain from eating food and drink for 1 hour.
If there is no improvement after treatment, or the symptoms worsen, or new symptoms appear, it is necessary to consult a doctor.
Use Grammidin spray only according to the indications, the method of administration and the doses indicated in the instructions.

Side effects

Allergic reactions to the drug components are possible.
If you have side effects indicated in the instructions, or are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Drug Interactions

At present, no cases of clinically significant interaction with other drugs have been described.

Overdose

Symptoms: the use of Grammidin spray in doses exceeding the recommended levels, can cause violations of the gastrointestinal tract: nausea, vomiting, diarrhea. Treatment: discontinue use of the drug and consult a doctor.

Storage conditions

In the original packaging at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
Shelf life - 2 years.

Terms of sell

You can buy Grammidin spray on this page.