Amlotop tabs 10mg #30

Amlotop instruction for use

You can buy Amlotop here

Composition

In 1 tablet, amlodipine besylate is equivalent to amlodipine 5 mg or 10 mg.
Lactose monohydrate, MCC, calcium stearate, impellose, silicon dioxide, - as auxiliary substances.

Form of issue

Pills.

pharmachologic effect

Hypotensive.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Asked from what Amlotop? You can give an answer - lowers blood pressure and reduces pain in the heart, that is, has antihypertensive and anti-anginal action. It is a blocker of calcium channels of the second generation - it blocks the passage of calcium into the cell.
The hypotensive effect is explained by the influence on the muscles of the vessels, which causes the vasodilation to expand. The hypotensive effect depends on the dose and lasts 24 hours. A sharp decrease in blood pressure is not observed. Amlotop does not affect the conduction and contractility of the heart muscle.
Antianginal action is explained by the expansion of coronary vessels and peripheral.
Expanding the coronary arteries increases the flow of oxygen into the heart muscle, the expansion of peripheral arterioles is accompanied by a decrease in OPSS, a decrease in preload in the heart. Prevents the development of angina attacks, reduces their frequency when performing physical exertion.
In patients with IHD, mortality from myocardial infarction and stroke decreases. Amlodipine does not increase the risk of complications in patients with CHF. Does not affect the concentration of blood lipids. Has natriuretic effect, inhibits platelet aggregation. In diabetes mellitus with kidney damage does not increase microalbuminuria.

Pharmacokinetics

After intake is slowly absorbed. Bioavailability is 60-65%. The maximum concentrations in the blood are observed after 6-12 hours. It binds to proteins by 90-97%. It is subject to slow metabolism with the formation of inactive metabolites. The effect of "first passage" through the liver is noted.
T1 / 2 is 36-50 hours. It is excreted mainly by the kidneys. In elderly people, as well as in hepatic and severe heart failure, T1 / 2 increases and is 60-65 hours. T1 / 2 does not change in individuals with renal insufficiency.

Indications for use

Monotherapy or combination with other means:
    arterial hypertension;
    angina of Prinzmetal;
    stable exertional angina.

Contraindications

    arterial hypotension (with systolic blood pressure less than 90 mm Hg);
    aortic stenosis, manifested clinically;
    cardiogenic shock;
    collapse;
    pregnancy;
    lactation;
    age to 18 years;
    hypersensitivity.
With caution should be used in hypertrophic cardiomyopathy, CHF III-IV functional class, violations of liver function, mitral stenosis, acute myocardial infarction.

Side effects of Amlotop

Most common:
    peripheral edema, palpitations, rush of blood to the face;
    fast fatigue, headache, drowsiness;
    pain in the abdomen, nausea.
Less common side effects:
    a sharp decrease in blood pressure;
    fainting, asthenia, increased sweating, paresthesia, emotional lability, tremor, insomnia;
    vomiting, constipation, bloating, dyspepsia, dry mouth;
    arthralgia, myalgia, muscle cramps, back pain;
    change in body weight;
    shortness of breath, epistaxis, rhinitis;
    frequent urination, nocturia, painful urge to urinate;
    ringing in the ears, doubling in gas, disruption of accommodation;
    alopecia, dermatitis;
    skin itching, rash;
    gynecomastia, impotence.

Instructions for use Amlotop (Method and dosage)

Tablets are taken orally 1 time per day. Take the tablets with plenty of water.
With arterial hypertension and angina, Amlotop is prescribed at a dose of 5 mg. If necessary, after 2 weeks, increase the dose to 10 mg.
Patients with low weight and low growth, individuals aged and with violations of the liver in order to reduce blood pressure prescribed 2.5 mg, as an antianginal agent in a dose of 5 mg.
In a dose of 2.5 mg used in combination with other antihypertensive drugs. Instructions for use Amlotop contains information that when renal failure is not necessary to adjust the dose of the drug.

Overdose

Overdosage is manifested by symptoms: a significant decrease in blood pressure with the development of reflex tachycardia, peripheral vasodilation, possibly the development of shock.
Treatment begins with the lavage of the stomach, sorbents are assigned (in the first 2 hours), maintaining the function of respiration and the cardiovascular system. Conduction of symptomatic therapy: iv calcium gluconate, vasoconstrictor drugs.

Interaction

There is an increase in effects with simultaneous use with beta-adrenoblockers, nitrates, ACE inhibitors, diuretics.
When taken with neuroleptics, an increase in the hypotensive effect is possible. Calcium preparations can reduce the effect of the drug. Antiviral drugs increase its concentration in the blood.
There is no significant interaction with NSAIDs. There is no negative inotropic effect when used with antiarrhythmic drugs. Do not change the concentration of Digoxin and its clearance with the simultaneous use of these drugs.
Cimetidine does not change the pharmacokinetics of amlodipine. The use of antacids and sildenafil also does not affect the pharmacokinetics of this drug.
Amlodipine does not affect the pharmacokinetics of Cyclosporine and the change in prothrombin time when taking Warfarin.
The use of amlodipine with atorvastatin does not affect the pharmacokinetics of atorvastatin. Single intake of grapefruit juice is not accompanied by a change in the pharmacokinetics of the drug.

Terms of sale

To buy Amlotop online the prescription is not required.

Storage conditions

Store in a dry place at a temperature of no more than 25 ° C.
Shelf life - 3 years.

Reviews

The drug is prescribed for hypertension and angina pectoris. Analyzing reviews about the drug, you can make a conclusion about the effectiveness of the drug. Users also note the availability of it in the pharmacy network and an acceptable cost.
"I take 5 mg per day, it stabilizes the pressure well, it suits me"
"I take amlodipine for 2 years, I am satisfied with the result."
"The drug is effective, I take a year. Angina pacified, but drowsiness is the most important side effect "
Negative opinion develops in patients who have side effects.
"On the fourth day of reception there were pains with urination"
"From amlodipine and itch, at a price very much suited"
"... lowers blood pressure very well, but it hurts the head and does not have a good general state of health"
"... well reduces pressure. But the problem of edema is very urgent - I had to give up "
"It causes a strong puffiness".
"... the ankles swell very much, but I can not give up the drug"
When asked about the swelling of the lower extremities, cardiologists respond that this drug is a frequent phenomenon. If the swelling is not very pronounced, does not interfere and does not limit the ability to work, then this side effect can be reconciled.