Amlodipine tabs 10mg #60

Instruction for Amlodipine

Reed more and buy Amlodipine on this page

Composition

Contains amlodipine besylate in its composition, in the equivalent of pure amlodipine at 5 and 10 mg.
Additional substances are: crospovidone, lactose monohydrate, calcium stearate, povidone.

Form of issue

Produced in the form of tablets of 10, 20, 30, 40, 50 or 100 pieces. The active ingredient is 5 or 10 mg per tablet.

pharmachologic effect

A hypotensive agent with an antianginal effect.

Pharmacodynamics and pharmacokinetics

INN: Amlodipine.
The active component is a dihydropyridine derivative. The principle of action is aimed at blocking the slow calcium channels. The drug has an antihypertensive effect. The main substance binds to dihydropyridine receptors, has a blocking effect on the calcium channels, slows the transmembrane transition of calcium ions into the cell (in the smooth muscle tissue of the vessels is somewhat larger than in the cariomyocytes). The antianginal effect of amlodipine is achieved by the expansion of arterioles, peripheral arteries, coronary arteries, which, with angina, can reduce the severity of myocardial ischemia. Under the influence of the active component, the lumen of the arterioles, coronary arteries widens in ischemic and unaffected parts of the myocardium, and the formation of constriction of the coronary arteries (during smoking) is prevented. The hypotensive effect of the drug is dose-dependent. One-time intake of medicament for arterial hypertension allows you to achieve clinically significant drop in blood pressure during the day. The drug does not affect the ejection fraction in the left ventricle, does not cause a decrease in tolerance to physical exertion, does not cause a sharp drop in blood pressure. The drug has cardioprotective, anti-atherosclerotic effects in IHD. Amlodipine increases the rate of glomerular filtration, inhibits platelet aggregation, does not cause a reflex increase in the pulse, and has a mild natriuretic effect. The severity of microalbuminuria does not increase in patients with diabetic nephropathy. The drug does not affect plasma lipids, metabolic processes. The effect of taking a single dose of amlodipine is observed after 2 hours, lasting a day.

Indications for use Amlodipine

What are the tablets used for?

The drug is used for arterial hypertension, with vasospastic angina, angina of stress, decompensated form of CHF, painless variant of myocardial ischemia.
Indications for use Amlodipine Biocom are the same, as the active substances of these drugs are the same.

Contraindications

Contraindications to the use of the drug are: intolerance dihydropyridines, pregnancy, severe course of arterial hypotension, breast feeding. With aortic stenosis, arterial hypotension, acute myocardial infarction, renal pathology, children before adulthood, with CHF, mitral stenosis, elderly patients with SSSU, GOKMP, Amlodipine is administered with caution.

Side effects of Amlodipine

The digestive tract: dry mouth, icterus of the skin, nausea, increased level of liver enzymes, vomiting, dyspeptic disorders, pancreatitis, flatulence, diarrhea, constipation, gingival hyperplasia, epigastric pain, and appetite disorders.
Nervous system: convulsions, mood changes, drowsiness, headache, depression, nervousness, insomnia, malaise, fatigue, asthenia, tremor, paresthesia, hyperesthesia, amnesia, agitation, apathy, ataxia.
Cardiovascular system: ventricular tachycardia, swelling, rhythm disturbances, blood flushes to the face, palpitations, retrosternal pains, blood pressure drop, migraine, extrasystole, atrial flutter, aggravation of heart failure, orthostatic hypotension, elevation of blood pressure.
Genitourinary system: polyuria, pollakiuria, nocturia, pain when urinating, violations of sexual functions, potency disorders, dysuria.
Musculoskeletal: myasthenia gravis, arthrosis, arthralgia, myalgia.
Skin: alopecia, xeroderma, purpura, dermatitis. It is also possible to develop conjunctivitis, rash, itching, diplopia, visual impairment, gynecomastia, ringing in the ears, chills, xerophthalmia, accommodation, parasymia, rhinitis, coughing, sticky sweat, epistaxis, hyperglycemia, thirst, increased sweating, perception.
Feedback on the side effects of Amlodipine occur quite often.

Tablets Amlodipine, instructions for use (Method and dosage)

The drug is taken orally, the initial dosage is 5 mg. The amount of the drug is gradually increased within two weeks to a maximum of 10 mg per day once. The maintenance, daily dosage for arterial hypertension is 2.5-5 mg. With vasospastic angina pectoris, stress stenocardia appoint a single dose of 5-10 mg per day. For the prevention of angina attacks, a daily intake of 10 mg is indicated. Patients with kidney pathology, with low body weight, low growth appoint 2.5 mg per day, to achieve an antianginal effect - 5 mg. The initial dosage for CHF is 2.5 mg per day, the dosage is gradually increased to 10 mg per day with good drug tolerance.
Instructions for use Amlodipine Teva, Amlodipine Pharmac and Biocom are similar.

Overdose

It is accompanied by tachycardia, excessive drop in blood pressure, peripheral vasodilation. Requires gastric lavage, control of diuresis and bcc, the appointment of enterosorbents, intravenous dopamine, calcium gluconate, maintenance and symptomatic therapy. Hemodialysis is recognized as ineffective.

Interaction

Indomethacin (blockade of prostaglandin synthesis by renal system, sodium ion delay), sympathomimetics, estrogens, alpha-adrenostimulants, NSAIDs weaken the severity of the hypotensive effect. Inhibitors of microsomal oxidation increase the risk of side effects due to an increase in the concentration of medication in the blood, the reverse effect is observed when taking inducers of microsomal enzymes. Nitrates, looped diuretics, verapamil, beta-adrenoblockers, thiazide diuretics, ACE inhibitors increase the severity of hypotensive and antianginal effects. Antipsychotic drugs, alpha1-adrenoblockers, quinidine, amiodarone, BCCC increase the hypotensive effect of amlodipine. Warfarin, cimetidine and digoxin do not affect the pharmacokinetic parameters. When taking lithium drugs, an increase in neurotoxicity (tinnitus, ataxia, diarrhea, nausea, tremor, vomiting) is recorded. Calcium preparations decrease the effectiveness of BCCC. Quinidine, procainamide strengthens the negative inotropic effect.

Terms of sale

To buy Amlodipine the prescription is not required.

Storage conditions

In a dark place inaccessible to children at a temperature of no more than 25 degrees Celsius.
Shelf life not more than 3 years.

special instructions

There is no reliable information about the safety of amlodipine for lactating and pregnant women. Therapy is required to be observed by the dentist for the prevention and timely diagnosis of gingival hyperplasia, their bleeding and soreness. The drug has no effect on plasma concentrations of cholesterol, triglycerides, glucose, uric acid, urea, nitrogen, LDL. The medication is not characterized by the "withdrawal" syndrome, but patients are recommended to gradually reduce the dosage of the drug before it is canceled.
The drug is often used in combination with various active substances: Valsartan, Perindopril, Lizinopril, Bisoprolol.

Reviews about Amlodipine

Doctor's comments

The drug is an effective remedy for heart disease. It is often used for the prevention of heart attack and angina pectoris. The medicine and its dosage must be prescribed by a doctor.
Reviews about Amlodipine Teva characterize the remedy as a good drug for reducing blood pressure. Also a plus is the low price of the medication. However, side effects often appear.