Normodipine tabs 10mg #30

Normodipine user manual

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Composition

One tablet of Normodipine contains 5, 10 mg of amlodipine.
Excipients: 2 mg magnesium stearate, 4 mg sodium carboxymethyl starch, 63 mg calcium anhydrous hydrophosphate and 124 mg microcellulose (MCC).

Form of issue

Produced in white tablets, biconvex oblong-rounded shape, on one side there is an engraving "5". In the carton pack 30 tablets, in blisters for ten pieces.

pharmachologic effect

Has hypotensive (lowering blood pressure) and antianginal action.

Pharmacodynamics and pharmacokinetics

Normodipine is a dihydropyridine antagonist of calcium ions and a blocker of slow Ca-channel (BCC), which slows the transport of calcium through the membranes of smooth muscle cells of blood vessels and heart - cardiomyocytes. The therapeutic effect is manifested in a decrease in the tone of the smooth muscles of the arterioles and a decrease in the overall atrial load.
In the case of coronary heart disease, the tolerance of active physical activity increases and the attacks of angina become less frequent, the need for nitroglycerin decreases.
The antianginal effect of the drug consists in the expansion of peripheral vessels, normal coronary and afflicted with atherosclerosis, which reduces the afterload on the myocardium without potentiating the reflex increase in heart rate, while the need to supply oxygen decreases.
The process of absorption from the digestive canal is slow and almost complete, and the diet does not affect the absorption of the drug, 85-97% binds to plasma proteins. Achieved by max. concentration in the blood plasma after 6-12 hours.
Absolute bioavailability of amlodipine within 64-80 percent, biotransformation occurs in liver cells to metabolites that do not have activity. Elimination biphasic through the kidneys: metabolites (approximately 60 percent), unchanged (10 percent) with a half-life of 35-50 hours.

Indications for use Normodipine

Indication for the use of tablets Normodipine are arterial hypertension and vasospastic form of angina pectoris, including angina of Prinzmetal, stable angina of tension.
The course of treatment can be prescribed either in the form of monotherapy, or in combination with other antianginal drugs.

Contraindications

The drug is not recommended for:
    severe arterial hypotension - with systolic blood pressure ≤90 mmHg;
    cardiogenic shock;
    collapse;
    unstable angina;
    stenosis of the aorta;
    during pregnancy and lactation;
    age category up to 18 years;
    hypersensitivity to amlodipine and other components of the drug.
With caution appoint this drug for mitral stenosis and cardiomyopathy.

Side effects

Concerning various systems and organs, the following side effects are observed:
    Cardiovascular system: accelerated heartbeat, myocardial infarction, arrhythmia, ventricular tachycardia, bradycardia, atrial fibrillation, hot flushes, arterial hypotension, vasculitis.
    Central nervous system: drowsiness, fainting, headaches, tremor, dysgeusia (taste distortion), hypoesthesia (increased sensitivity threshold), paresthesia (sensation of numbness), peripheral neuropathy.
    Digestive system: abdominal pain, vomiting, dyspepsia, changes in the defecation regime, diarrhea and constipation, dry mouth, gingival hyperplasia, pancreatitis, gastritis.
    Hematopoietic organs and lymphatic system: leukocytopenia, thrombocytopenia.
    Liver, biliary tract: jaundice, hepatitis, increased activity of liver transaminases.
    Genitourinary system: urination disorders, including nocturia (frequent urination); impotence, gynecomastia.
    Skin: alopecia, skin discoloration, purpura, hyperhidrosis, itching, eruptions, erythema, urticaria, dermatitis, Stevens-Johnson syndrome, photosensitivity.
    Support system: arthralgia (pain in the joints), myalgia, pain, cramps in the muscles.
    Respiratory system: rhinitis, cough, dyspnea (dyspnea).
    Immune system: allergic reactions.
    Sensory organs: visual impairment, binocular vision disorders - diplopia (doubling); noise in ears.
    Metabolism: hyperglycemia.

Instructions for use Normodipine (Method and dosage)

Normodipine is taken orally, starting with a therapeutic dose for hypertension or angina pectoris - 5 mg per day. The maximum permissible daily dose at one time is not more than 10 mg, the permissible maintenance dose for arterial hypertension is 5 mg per day, that is, 1 table. 5 mg per day.
Discontinuation of reception does not cause the development of withdrawal syndrome, however, the completion of the course of treatment should be gradual, with a step-by-step reduction in the dose.
Instructions for use Normodipine for the elderly
The drug can increase the half-life of the active substance - amlodipine, which will lower the creatinine clearance, while changing the dosage in this case and with renal failure is not necessary, however, more careful monitoring of the patients' condition is recommended.

Overdose

It is accompanied by the following symptoms:
    tachycardia;
    marked decrease in blood pressure;
    peripheral vasodilation with the risk of development of severe persistent arterial hypotension, up to the development of shock and death.
Prescribe treatment in the form of gastric lavage, the use of activated charcoal. The position of the patient should be as follows: horizontal position, lower limbs elevated above the level of the head.
To restore the tone of the vessels usually use vasoconstrictor (only in the absence of contraindications to them). Also, to eliminate the effects of calcium channel blockade, intravenous calcium gluconate is administered. Hemodialysis in this case is ineffective.

Interaction

The active substance - amlodipine can cause various reactions with simultaneous administration with the following agents and compounds:
    Thiazide and loop diuretics, verapamil, ACE inhibitors, β-blockers and nitrates can enhance the antianginal and hypotensive effect of slow calcium channel blockers (dihydropyridine series), including when combined with α1-blockers and antipsychotics.
    Antiarrhythmic drugs, for example Amiodarone, Quinidine - an increase in the negative inotropic effect towards the elongation of QT.
    Antiviral agents, for example Ritonavir - increase in concentration of slow calcium channel blockers in plasma, calcium preparations - decrease in effect, incl. amlodipine.
    Neuroleptics, Isoflurane - strengthening of hypotensive action of dihydropyridine derivatives.
    Lithium - manifestations of neurotoxicity in the form of nausea, vomiting, diarrhea, ataxia, tremor and noise in the ears.
    Cyclosporine, Digoxin, cimetidine-amlodipine does not significantly affect their pharmacokinetics.
    Warfarin (prothrombin time) - Normodipine does not have a significant effect not its pharmacological effect.
Amlodipine can be safely applied:
    Arterial hypertension: with thiazide diuretics, α- and β-adrenoblockers, ACE inhibitors.
    Stable angina: with other antianginal agents, for example, long-acting nitrates, β-adrenoblockers or short-acting nitrates.
    With traditional NSAIDs (especially with Indomethacin), in addition with antibacterial and hypoglycemic agents (ingestion).

Terms of sale

You don't need a prescription to buy Normodipine online.

Storage conditions

In a place inaccessible to children, at a temperature not exceeding 30 ° Celsius.
Shelf life - three years.

special instructions

Treatment with Normodipine should be accompanied by control of body weight and sodium intake, up to the appointment of an appropriate diet. In addition, careful maintenance of dental hygiene and regular visits to the dentist are recommended to prevent soreness, bleeding, and gingival hyperplasia.
Patients with low body weight, low growth, or impaired liver function require an individual calculation of the dosage downward.

With alcohol

The administration of a single dose of 10 mg and the repeated use of the drug of the same dose does not affect the pharmacokinetics of ethanol, including products containing alcohol.

Reviews of Normodipine

This drug is used by many hypertensive patients and patients with pathologies of the heart. The effectiveness of treatment Normodipine can be found both positive and negative statements. On forums, the situation is most often discussed: this antihypertensive drug initially has a noticeable effect, and subsequently stops normalizing the pressure.
The doctors' comments about Normodipine are positive and they often include it in the treatment regimen, however it is undesirable to apply this medication alone. It is recommended to consult a doctor in charge, rather than on the Internet.