Captopril tabs 25mg #40

Captopril instruction for use

Reed more and buy Captopril on this page

Composition

Active component is Captopril. Additional substances: lactose, anhydrous colloidal silicon dioxide, corn starch, castor hydrogenated oil.

Form of issue

Captopril is available in tablet form. The dosage depends on the manufacturer. Allowable dosage: 12.5, 25, 50 and 100 mg. Tablets are packed in blisters of 10 pieces. Each pack of cardboard contains 2 blisters and instructions from the manufacturer.

pharmachologic effect

The drug has an antihypertensive effect. The active substance inhibits the angiotensin converting enzyme, which prevents the conversion of angiotensin I to form II. It is angiotensin II is the basic component of the renin-angiotensin system, which has a pronounced vasoconstrictive (vasoconstrictor) effect. By reducing the level of angiotensin II, reducing the production of aldosterone and by accumulating the vasodilator bradykinin, an antihypertensive effect is achieved.
The medication reduces the overall resistance of the blood vessels to the blood flow, reduces the level of postload and pressure in the small circle of the circulation. The drug of pressure is additionally capable of reducing the level of aldosterone in the adrenal glands.

Pharmacodynamics and pharmacokinetics

About 75% of the active substance is absorbed quickly enough from the digestive system. Eating can reduce absorption by 30-40%. The maximum level of active substance in the blood is recorded after 30-90 minutes. With albumin, the active substance binds to 25-30%.
Captopril is excreted with milk during lactation. Metabolism is carried out in the hepatic system. Metabolites do not have pharmacological activity. 95% of the drug is excreted through the renal system, almost half - in its original form, the rest - in the form of metabolites. With pronounced renal pathology, the effect of cumulation (accumulation) is observed.

Indications for use of captopril

Captopril tablets from what? The drug is used mainly to stop the hypertensive crisis, reduce blood pressure.
The main indications for the use of captopril
    renal hypertension;
    essential hypertension (a rise in blood pressure of an unclear etiology);
    malignant hypertension (with resistance to other medicines).
From what Captopril Akos? Indications for use Captopril Akos
    diabetic nephropathy in patients with diabetes mellitus (type 1);
    left ventricular dysfunction in patients who underwent myocardial infarction and reached a clinically stable state.

Contraindications

Tablets of captopril from pressure are widely used in cardiological practice, but they have certain contraindications to the use:
    narrowing of the aorta;
    primary hyperaldosteronism;
    narrowing of the mitral valve;
    condition after kidney transplant;
    bearing pregnancy;
    stenosis of the arteries of the kidneys;
    propensity to edema formation;
    individual hypersensitivity;
    myocardiopathy;
    breast-feeding.
In pediatric practice, a medication can be prescribed only after reaching the age of 14 years. Patients are advised to refrain from work, which requires concentration of attention.

Side effects

From the side of the nervous system, the following side effects can occur:
    paresthesia;
    migraine headache;
    dizziness;
    asthenia;
    fast fatiguability.
The cardiovascular system:
    cardiopalmus;
    orthostatic hypotension.
The digestive tract:
    pancreatitis;
    cholestasis;
    disorders of stool (diarrhea syndrome or constipation);
    epigastric pain;
    violation of taste perception;
    nausea;
    hepatitis;
    increased bilirubin levels;
    increase in ALT and AST.
The system of hematopoiesis:
    a decrease in the number of platelets;
    anemia;
    neutropenia;
    agranulocytosis (in the presence of autoimmune pathology).
Metabolism:
    acidosis;
    increase in the level of K + in the body.
Urinary system:
    disorders in the work of the kidneys;
    detection of protein in the urine.
In some cases, a dry, unproductive cough is recorded. Allergic responses are possible:
    bronchospasm;
    the presence of antinuclear antibodies;
    edema of Quincke;
    lymphadenopathy;
    serum sickness.
When registering other adverse reactions, a doctor's consultation is required and a temporary independent withdrawal of the drug Captopril.

Instructions for use (Method and dosage)

Tablets are intended for ingestion. The medicine quickly enough reduces blood pressure. Only the attending physician may prescribe Captopril tablets. Instructions for use in hypertensive crises: a tablet dose of 25 mg is placed under the tongue, which provides a faster hypotensive effect. Instructions for use Captopril Acos in the Renovascular form of hypertension: three times a day for 12.5 mg. The effectiveness of the drug increases with fasting.
Treatment with the drug Captopril Stade is recommended starting with small dosages: at 6.25-12.5 mg twice a day, gradually increasing the dose depending on blood pressure.
How to take medication for heart failure: three times a day for 12.5-25 mg. The maximum daily dosage is 150 mg.
At what pressure do I take Captopril? The drug belongs to the group of "first aid" medications and is recommended for use in emergency cases, when against the background of treatment according to the standard scheme there was an increase in pressure to high figures against the background of stress, physical activity.

Overdose

Before you buy Captopril you should know possible overdose reactions.
If the tablets are not taken correctly, an overdose can occur, which is manifested by a marked decrease in the level of blood pressure. The patient's condition can be complicated by thromboembolism, impaired cerebral blood supply, myocardial infarction.
It is recommended to give the patient a horizontal position, raise the lower limbs, try to restore blood pressure by intravenous infusion of saline. Peritoneal dialysis does not give the expected effect. Against the background of hemodialysis, there is a positive trend.

Interaction

Together with the use of cytostatics and immunosuppressants, leukopenia can develop. Perhaps the development of hyperkalemia with simultaneous therapy with potassium-sparing diuretics:
    Amyloride;
    Spironolactone;
    Triamterene.
Against the backdrop of Azathioprine treatment, anemia can occur, due to oppression of the activity of Erythropoietin. The medical literature describes cases of diagnosing leukopenia associated with additive bone marrow hematopoiesis. Allopurinol may increase the severity of hematologic effects. Acetylsalicylic acid is able to reduce the hypotensive effect of Captopril. The medication is able to increase the concentration of Digoxin. Most often, the drug interaction manifests itself in patients with a marked pathology of the renal system. Captopril and Cinnarizine are not contraindicated.

Storage conditions

The manufacturer recommends a temperature regime in the range of 15-25 degrees. Limit children's access to blisters.
Shelf life - 4 years.

special instructions

During treatment, a false positive reaction can be detected when determining acetone in the urine. In pediatric practice, medication can be used in the absence of the effect of other antihypertensive agents.

Captopril and alcohol

Alcohol can enhance the hypotensive effect of the drug. There is a joint negative effect on the liver system.

Reviews about Captopril

This is one of the most discussed antihypertensive drugs on the Internet. Many patients share their long experience of treatment with Captopril and note its high effectiveness in emergency cases, when usual daily therapy does not help and the pressure remains on high figures.
There are reviews about Captopril, among which quite often described such a side effect, as a dry cough, characteristic for all drugs of the ACEI group. In general, patients' reviews of Captopril are positive.