Fosicard tabs 20mb #28

Instruction for Fosicard

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Composition

One tablet contains the active ingredient: Fosinopril sodium.
Auxiliary components: lactose monohydrate, corn pregelatinized starch, croscarmellose sodium, MCC and glycerol dibehenate.

Form of issue

Issued Fosicard in the form of tablets, which contain 5, 10 or 20 mg of the main substance, packaged in 10 pieces in a contour mesh package, nested in 3 pieces per pack.

pharmachologic effect

The drug has a vasodilating and hypotensive effect.

Pharmacodynamics and pharmacokinetics

The drug has a pronounced antihypertensive and vasodilating effect. Its main component is metabolized internally, resulting in the formation of a pharmacologically active substance - fosinoprilat. The mechanism of therapeutic action is manifested by inhibition of the activity of the angiotensin-converting enzyme, which allows to prevent the transfer of angiotensin-I into angiotensin II, which has a noticeable vasoconstrictor effect. Also slows down the disintegration of bradykinin, which can dilate blood vessels. At the same time, the overall peripheral resistance of the vessels decreases, the blood pressure decreases, pre- and post-loading on the myocardium.
These tablets are well absorbed in the digestive tract. The development of the therapeutic effect occurs within an hour, the maximum concentration is reached after 2-6 hours and lasts about 24 hours even with a single application. Prolonged reception does not promote the development of tolerance to fosinopril. This substance is characterized by an increased degree of binding to plasma proteins, about 95%. The removal of fosinoprilata occurs with the help of kidneys and liver. On average, the half-life reaches 11.5 hours.

Indications for use of Fosicard

The main indications for the use of Fosicard:
    chronic heart failure;
    arterial hypertension.

Contraindications for use

It is not recommended to take this medication with:
    hypersensitivity to fosinopril and other components;
    hereditary or idiopathic angioedema;
    lactation, pregnancy;
    age to 18 years.
Care must be taken when:
    renal failure;
    hyponatremia;
    bilateral stenosis of the renal arteries and artery of a single kidney;
    condition after kidney transplantation, desensitization, some systemic diseases of connective tissues;
    hemodialysis;
    cerebrovascular diseases, for example, cerebral circulatory insufficiency;
    diabetes mellitus;
    aortic stenosis;
    oppression of bone marrow hematopoiesis;
    old age and so on.

Side effects

In the treatment of Fosicard may occur side effects affecting the activities of all systems and organs. For example, the cardiovascular system can respond with a decrease in blood pressure, orthostatic hypotension, tachycardia, palpitation, arrhythmia, angina pectoris, myocardial infarction and pain in the chest.
Deviations in the digestive system in the form of nausea, vomiting, constipation, intestinal obstruction, pancreatitis, hepatitis, stomatitis, glossitis, dyspepsia, abdominal pain, anorexia, and so on are also possible.
In addition, the occurrence of disorders associated with the activities of the respiratory, urinary and nervous systems is not excluded.
The probability of damage to sensory organs, the development of allergic reactions and changes in laboratory parameters are preserved.

Fosicard - instructions for use (Method and dosage)

Fosicard tablets are intended for ingestion. Usually the dosage and duration of treatment is selected individually, but there are a number of standard rules.
As the instruction on the use of Fosicard informs, during the treatment of hypertension it is recommended to stop taking any hypotensive drugs in advance.
The initial daily dosage of this drug is 1 time for 10 mg. In the future, a dose selection is necessary taking into account the parameters of blood pressure. In this case, the maintenance daily dose can be 1 time for 10-40 mg. If monotherapy with Fosicard does not bring a positive effect, then it is permissible to attach a diuretic.
When they start taking this drug with a diuretic, they prescribe an initial dose of up to 10 mg, carrying out a thorough medical monitoring of the patient's condition.
During the treatment of chronic heart failure, an initial daily dose of 10 mg is established. Gradually perform a weekly dose increase of 10 mg. The maximum dosage should not be above 40 mg / day. Also additionally, a diuretic can be taken.

Overdose

Cases of overdose can cause a pronounced lowering of blood pressure, a bradycardia, a shock state, a violation of water-electrolyte equilibrium, acute renal failure, or stupor.
At the same time, it is required to stop using Fosicard, to lay the patient, lifting his legs and performing symptomatic treatment. In light cases of overdose, it will be sufficient to wash the stomach, apply adsorbents, sodium sulfate.

Interaction

Simultaneous use of the drug with antihypertensive drugs, diuretics, narcotic analgesics, general anesthetics can strengthen the hypotensive effect of fosinopril.
The combination with potassium preparations and some potassium-saving diuretics increase the likelihood of hyperkalemia. Simultaneous use with lithium salts increases the concentration of lithium in the blood.
Fosicard increases the hypoglycemic effect of sulfonylurea derivatives, insulin, increases the risk of manifestation of leukopenia in cases of simultaneous use with allopurinol, immunosuppressants, cytostatic drugs, procainamide. Combination with NSAIDs and estrogens reduce the severity of hypotensive action.

special instructions

Treatment with Fosicard patients suffering from severe arterial hypertension or decompensated chronic heart failure, it is recommended to begin in the hospital. In this case, the therapeutic process requires control of blood pressure, kidney function, hemoglobin, urea and creatinine, the concentration of electrolytes and potassium, the activity of hepatic enzymes in the blood.
Also periodically it is necessary to control the number of leukocytes, especially if there is a risk of neutropenia, for example, in cases of impaired renal function or systemic diseases of connective tissues.
The possible increase in the development of arterial hypotension requires caution, when the drug is prescribed to patients who are on a salt-free or low-fat diet.
Taking this medication can cause dizziness, usually at the beginning of treatment when combined with diuretics, so you need to be careful in activities that require special attention or when driving vehicles.

Terms of sale

To buy Fosicard the prescription is not required.

Storage conditions

For storage of tablets, a dark place is intended at a temperature of up to 30 C, well protected from children.
Shelf life - 2 years.

Fosicard H Tablets

The difference of this drug lies in its composition, which includes fosinopril sodium and an additional substance - hydrochlorothiazide. This causes its pharmacological action - hypotensive, potassium-sparing, vasodilating and diuretic.

Alcohol

During treatment with Fosicard, it is recommended to refrain from drinking alcohol, which is capable of lowering its hypotensive effect.

Reviews about Fosicard

This drug is usually prescribed for hypertension, but it should be understood that such treatment does not bring a full recovery. At the same time, reviews of the Physicard show that complex therapy is administered to patients who have been troubled by this disease for several years.
As experts say, treatment of hypertension requires the right approach and perseverance. Therefore, patients need to follow the doctor's prescription without violating the therapeutic regimen and not stopping treatment on their own. In addition to taking medications, you must adhere to a healthy lifestyle, perform procedures that strengthen the blood vessels.