Enalapril tabs 10mg #20

Enalapril user manual

Reed more and buy Enalapril on this page

Composition

The tablet contains the active substance enalapril in the amount of 5, 10, 20 mg, as well as auxiliary substances: gelatin, lactose monohydrate, magnesium stearate, magnesium carbonate and crospovidone.

Form of issue

Tablets of 10 pieces per blister, 2 blisters per pack.
It is produced by different pharmaceutical companies, so the name of the product is added to the name of the active substance, for example: Enalapril-Health.

pharmachologic effect

The medication reduces pressure, expands the lumen of blood vessels, has cardioprotective and natriuretic action. The drug refers to the group of angiotensin converting enzyme inhibitors.
Pharmacological group: ACE inhibitors.

Pharmacodynamics and pharmacokinetics

According to the annotation, the mechanism of action is the inhibition of angiotensin-converting enzyme (ACE) by Enalapril, from which the decrease in the biosynthesis of angiotepsin II leads to vasodilation, the production of PGE2 and bradykinin, which are potent vasodilators.
In patients with heart failure with prolonged admission (6 months or more), there is an increase in heart-tolerance of physical exertion, the size of the heart decreases, and the number of deaths decreases. Under the action of the drug unloaded a small circle of blood circulation, the pressure in the pulmonary capillaries decreases, the OPSS decreases, cardiac output increases (heart rate does not increase).
Absorption of the drug Enalapril reaches 60% regardless of the intake and availability of food in the digestive tract. The maximum concentration of the active substance enalaprilata observed after 1h after application. In the liver, biotransformed to enalaprilata. It easily passes through the placenta, the histohematological barriers. It is excreted by the kidneys. The hypotensive effect is recorded 1 h after the drug administration, lasting a day. To achieve optimal BP results, several weeks of regular enalapril intake are required.

Indications for use Enalapril

From what tablets Enalapril?
Indications for the use of Enalapril are: hypertension, Raynaud's disease, heart failure, symptomatic arterial hypertension, diabetic nephropathy, scleroderma, secondary hyperaldosteronism. Enalapril is prescribed as a part of complex therapy in the treatment of angina pectoris, myocardial infarction, chronic renal failure. Apply the tablets from the pressure of increased.

Contraindications

Hypersensitivity to ACE inhibitors, stenosis of the renal arteries, azotemia, hyperaldosteronism, hyperkalemia, renal dysfunction, Quincke's edema (hereditary nature), stenosis of the aortic estuary, children's age. Enalapril is not prescribed for pregnant women.

Side effects

The drug has the following side effects: increased fatigue, dizziness, headache, convulsions, nervousness, insomnia, glossitis, tinnitus, dry cough, nausea, orthostatic hypotension, palpitations, dyspeptic disorders, proteinuria, impotence, liver, kidney, hyperkalemia, Quincke's edema, neutropenia, increased bilirubin level in the blood, hair loss, pain in the heart area, increased concentration of hepatic transaminases.

Enalapril tablets, instructions for use (Method and dosage)

The medicine is taken internally. The initial dosage is 5 mg per day, the drug is taken 1 time per day. With the pathology of the renal system, the intake of diuretics dose is reduced to 2.5 mg. To achieve the effect, depending on individual characteristics, the dose of the drug can be increased to 10-40 mg per day (can be divided into 2 doses).

Instructions for use Enalapril Hexal

The drug is used regardless of the meal.
With arterial hypertension should take 5 mg of enalapril maleate in the morning. The maintenance dose is 10 mg. Do not take more than 40 mg of the drug per day.
In chronic heart failure take 2, 5 mg of medicine in the morning. The maintenance dose is 5-10 mg. Do not take more than 20 mg of the drug per day.
With left ventricular dysfunction take 2.5 mg twice a day. The maintenance dose is 10 mg twice daily.
How to take if you have kidney problems? In this situation, use 2.5 mg per day. The maintenance dose is usually 5-10 mg. The maximum dose is 20 mg per day.

Instructions for use Enalapril Acry

Anytime. First take 2.5-5 mg once every 24 hours. The maintenance dose is 10-20 mg once every 24 hours. The maximum dose is 40 mg for 1-2 doses.
Instruction for Enalapril FPO
It is similar to the method of dosage of the previous preparation.

The regimen of enalapril H

1-2 tablets once every 24 hours regardless of meal intake.

Overdose

Excessive drop in arterial pressure, myocardial infarction, ONMI, thromboembolic complications as a result of a sharp decrease in blood pressure. Treatment: iv administration of NaCl (isotonic solution). There is no specific antidote.

Interaction

Absorption of the drug is not dependent on food intake. With simultaneous reception with beta-adrenoreceptor blockers, nitrates, methyldopa, calcium antagonists, prazosin, hydralazines, Enalapril potentiates the hypotensive effect. Cimetidine increases T1 / 2 of the drug. NSAIDs increase nephrotoxicity, decrease the effectiveness of Enalapril. Potassium preparations and potassium-sparing diuretics when taken with drugs lead to hyperkalemia. Enalapril reduces the half-life of theophylline, reduces the clearance of lithium. LS does not interact with cardiac glycosides.

Terms of sale

A prescription is not required to buy Enalapril online.

Storage conditions

At temperatures up to 25 degrees Celsius in a dry place inaccessible to children.
Shelf life - 3 years.

special instructions

In the first hours of admission Enalapril can lead to a marked decrease in blood pressure. This is especially true in people who first take an antihypertensive drug in patients with CRF, severe heart failure, hypovolemia, hyponatremia. To prevent a sharp decrease in blood pressure 2-3 days prior to enalapril intake, diuretics and salt-free diets are canceled. With the development of angioedema on the face, neck, you must abolish the drug, prescribe antihistamines. In severe cases, intubation, tracheotomy is performed. It is not recommended to prescribe simultaneously potassium-sparing diuretics. It is necessary to regularly monitor hemostasis. Enalapril is not prescribed for women planning a pregnancy.
The medication was registered by WHO for the reference of Vidal.
It is often used with hydrochlorothiazide as a combined agent.
INN: Enalapril.

Lisinopril or Enalapril - which is better?

Lisinopril on the basis of research more effectively reduces blood pressure, and also operates a longer period of time. Both drugs are transferred approximately equally.

Enap and Enalapril - what's the difference?

In fact, the drugs are no different, since they have the same active substance. However, the price of Enap is much higher than the analog.

Reviews about Enalapril

The opinions of the doctors are that it is a very effective, widely used, high-quality preparation for blocking the ACE. Really reduces the pressure, however, and has a number of contraindications and side effects, for example, cough.
Reviews of Enalapril Hexal on the forums are generally also positive color. The drug effectively reduces blood pressure, is inexpensive, but has a frequent side effect.