Halidor tabs 100mg #50

Halidor user manual

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Composition

Each tablet of the preparation Halidor contains 100 mg of biciclan fumarate, as well as auxiliary substances: potato starch, polyvinyl acetate, magnesium stearate, carbomer 934 P, sodium carboxymethyl starch (type A), colloidal anhydrous silicon dioxide and talc.
The drug Halidor in the form of a solution for intramuscular and intravenous administration contains 25 mg per 1 ml of solution, 50 mg of biciclan fumarate per capsule. The solution also contains auxiliary substances: 8 mg of sodium chloride (in dosage forms for parenteral administration) and up to 2 ml of water for injection.

Form of issue

The medication is available in two forms:
    White or grayish white tablets, round in shape, flat, they have a bevel, engraved "HALIDOR" on one side of the tablet, there is a weak characteristic odor. Tablets of 50 pieces are put in bottles made of dark glass. Each bottle is placed in a cardboard box.
    Halidor injections - a solution for intravenous and intramuscular injection has the appearance of a transparent, colorless, odorless liquid. The solution is sold in ampoules (volume of each 2 ml). For 5 ampoules are placed in contour mesh packages, and contour mesh packs of 2 pieces are put in cardboard packs or 10 in cardboard boxes.

pharmachologic effect

Halidor is myotropic antispasmodic, has a pronounced vasodilating (vasodilating) effect.
Also, the drug can cause a slight increase in the heart rate, have a small tranquilizing effect.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Benzyclan has a vasodilating effect mainly due to its ability to block calcium channels, to have an antiserotonin effect, and to some extent - to create a blockade of sympathetic ganglia. Also, bcycliclane can cause a dose-dependent suppression of Na + / K + -dependent ATPase, a decrease in the aggregation of certain blood cells (platelets and erythrocytes), and increase the elasticity of red blood cells. Such effects are mainly observed in the coronary arteries, peripheral vessels and vessels of the brain.
In addition to the above, bcyclical has an antispasmodic effect on visceral musculature (musculature of the urinary tract, gastrointestinal tract, respiratory organs).

Pharmacokinetics

After taking Halidor inside, bicyclic is absorbed from the gastrointestinal tract quickly and almost completely. The maximum concentration in the blood plasma of the person who took the drug is usually achieved after 3 hours (but this interval can have a duration of 2 to 8 hours) after ingestion. Since there is a "first pass" effect through the liver, as a result, the bioavailability of the drug upon ingestion is 25-35%.
In circulating blood, bcycliclane is distributed approximately in such proportions:
    30-40% of the total amount of substance binds to plasma proteins;
    30% - binds to red blood cells;
    10% - with platelets;
    20% .- free fraction.
The metabolism of the drug occurs in the liver. During the metabolic processes dealkylation takes place, which eventually gives a demethylated derivative, or the ether bond breaks, resulting in the formation of benzoic acid, which subsequently turns into hippuric acid.
The half-life lasts from 6 to 10 hours. Drug is mainly given with urine as inactive metabolites, but can be excreted unchanged (no more than 2-3%). Most of the metabolites (about 90%) are excreted from the body in an unconjugated form, and a negligible proportion is excreted in conjugated form (of which approximately 50% is in the form of a conjugate formed with glucuronic acid).

Indications for use of Halidor

Indications for the use of Halidor are many. It is assigned when:
    diseases of peripheral vessels - with Raynaud's disease, other diseases in which acrocyanosis and vasospasm often develop, with chronic obliterating diseases of the arteries;
    diseases of cerebral vessels: it is used in complex therapy, both in acute and chronic forms of cerebral ischemia;
    occurrence of spasms of internal organs;
    gastrointestinal diseases - gastroenteritis of different etiology (especially when infectious), infectious and inflammatory colitis, functional diseases of the large intestine, tenesmus, postoperative flatulence, cholecystitis, cholelithiasis, condition after cholecystectomy, motor dyskinesia disorder in Oddi sphincter, gastric ulcer and duodenal ulcer (used as part of the combined therapy);
    urological syndromes: spasms and tenesms of the bladder, concomitant therapy of urolithiasis (prescribed in combination with anesthetic drugs for renal colic);
    preparation for instrumental research methods used in urology.

Contraindications

Contraindications for the use of the drug include:
    severe respiratory failure;
    renal failure (with severe failure);
    severe hepatic impairment;
    Decompensated heart failure;
    acute myocardial infarction;
    AV blockade;
    paroxysmal supraventricular or acute ventricular tachycardia;
    epilepsy and other forms of spasmophilia;
    recently suffered hemorrhagic stroke;
    craniocerebral trauma (their presence during the last year);
    pregnancy;
    the period of breastfeeding;
    age to 18 years;
    increased sensitivity to the constituents of the drug.

Side effects

On the part of some systems of the human body, a side effect of the drug is possible:
    Digestive system: dry mouth, abdominal pain, feelings of satiety, nausea, vomiting, decreased appetite, diarrhea may occur, serum levels of hepatic transaminases may increase.
    Central nervous system: there is a possibility of occurrence of anxiety, dizziness, headache, gait disturbance, tremor, sleep disorders, insomnia, memory disorders; there are rarely observed transitory confused states of consciousness, the appearance of epileptiform seizures, hallucinations; in isolated cases, the symptoms of focal lesions of the central nervous system appeared.
    Cardiovascular system: sometimes atrial and ventricular tachyarrhythmia develops (its probability is especially increased when Halidor is co-administered with other pro-arrhythmogenic drugs).
    In addition to the above side effects, there may be a general malaise, weight gain, development of leukopenia, allergic reactions; Thrombophlebitis is occasionally manifested with intravenous administration.

Instructions for the use of Halidor (Method and dosage)

With vascular diseases

Inside the medication is taken at 100 mg 3 times a day for 2 or 3 months. The maximum dose that can be taken orally within a day is 400 mg (tablet). Between the courses of taking the drug you need to do an interval of 2 to 3 months.
In the form of intravenous infusions the drug is taken in a dose of 200 mg (per day). The daily dose is divided into 2 injections. Before the infusion, 100 mg (contained in 4 ml solution for intravenous and intramuscular injection) of the drug must be diluted in 100-200 ml of isotonic sodium chloride solution, and then injected intravenously for 1 hour, this must be done 2 times in day.

With spasm of internal organs

Inside, prescribe 100-200 mg of the drug at a time, but not more than 400 mg per day.
In the case of maintenance therapy, Halidor is prescribed 100 mg 3 times a day for 3 or 4 weeks, then 100 mg twice a day. Duration of treatment is determined for each person individually and depends on when the symptoms of the disease disappear. As a rule, this period lasts no more than 1-2 months.
When used in acute cases, the drug is administered intravenously, respectively, instructions for the use of injections of Halidor - slowly in an amount of 100-200 mg (this is 4-8 ml of solution) or intramuscularly deep in an amount of 50 mg of the drug (2 ml solution). Before intravenous injection, the required dose of the solution is diluted with an isotonic solution of sodium chloride to 10-20 ml. The length of the course of treatment is 2 or 3 weeks, then, if necessary, the patient is transferred to Halidor's reception inside.

Overdose

In case of an overdose of the drug, heart rate is increased, blood pressure is lowered, collapse, renal impairment, urinary incontinence, drowsiness, anxiety, severe epileptiform seizures may occur. With a significant overdose, tonic and clonic convulsions may occur.
When an overdose is symptomatic therapy. If a large number of tablets has been taken, it is necessary to wash the stomach. In the case of convulsive seizures, the use of benzodiazepines is recommended. Specific antidote has not yet been found. There is no information as to whether it is possible to withdraw benzyclan by dialysis.

Interaction

The simultaneous use of Halidor with certain drugs can lead to side effects. Therefore, one should be cautious when combined with such drugs:
    Means for anesthesia and sedatives - this combination increases the oppressive effect of Halidor on the central nervous system.
    Sympathomimetics - simultaneous application increases the risk of developing a patient's tachycardia, atrial or ventricular tachyarrhythmias.
    Drugs that lower the level of potassium in the blood (such drugs include diuretics and cardiac glycosides) and quinidine - there can be a summation of pro-rhythmogenic effects.
    Drugs foxglove - increase the risk of arrhythmia in case of an overdose of cardiac glycosides.
    Beta-adrenoblockers - there is a need to adjust the dose of beta-adrenoblocker, as these drugs have opposite chronotropic effects (in beta-adrenoblockers the effect is negative, and in biciclane - positive).
    Calcium channel blockers and other antihypertensive drugs - it is possible to enhance the effect.
    Medicines that cause side effects in the form of spasmophilia - there is a possibility of summation of similar effects.
    Acetylsalicylic acid - may increase the inhibition of platelet aggregation.

Terms of sale

You can buy Halidor without a prescription.

Storage conditions

The drug should be stored in a place inaccessible to children in the temperature range from 15 ° C to 25 ° C.

Shelf life

Tablets are suitable for 5 years. Solution for injection is suitable for 3 years.

special instructions

At the beginning of the course of taking the drug should be very careful when driving cars and other vehicles, as well as any other activities that can be potentially dangerous.

Children

Do not appoint.

In pregnancy and lactation

Preclinical studies failed to reveal any embryotoxic or teratogenic effects, but at the same time, adequate and strictly controlled clinical studies on the use of Halidor during pregnancy and during lactation were not conducted. Therefore, taking the drug during the first trimester of pregnancy is undesirable.
If it is necessary to take the drug during the lactation period, it is necessary to decide the appropriateness of terminating breastfeeding for the period of treatment.

Reviews about Halidor

The doctors' comments about Halidor agree that the drug is strong enough and it is very important not to forget when applying it about caution, especially the elderly and people prone to allergies. Reviews on the forums also confirm a high probability of side effects in people prone to it.