Dibazol tabs 20mg #10

Instruction for Dibazol tablets

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The drug Dibazol refers to the pharmacological group of drugs - peripheral vasodilators. Its main pharmacological effect is the expansion of blood vessels, in particular arteries and arterioles. It is used for various pathologies, which is accompanied by narrowing of the vessels (spasm) and increased tonus of the walls of the hollow organs.

Form of issue and composition

Dibasol is manufactured in two dosage forms - tablets for oral administration and a solution for parenteral (intramuscular or intravenous) administration. The main active substance of the drug is bendazole. Its content in one tablet is 0.02 grams, in 1 ml of the solution its content is 0.01 g (10 mg or 1% solution).
Tablets are packaged in contour non-jammed packaging of 10 pieces. The solution for injections is contained in glass ampoules of 2 ml, the package contains 10 ampoules.

pharmachologic effect

The active substance of the drug Bendazol has several pharmacological effects, which include:
    Reducing the concentration of calcium ions in the smooth muscles, due to which it relaxes.
    Increase the synthesis of nucleotides and proteins in the cells of the body.
    Immunomodulating action - normalization of the functional activity of the immune system, the drug increases the synthesis of antibodies with lymphocytes, stimulates the activity of macrophages.
    Activation of synapses (interneural connections) of the nervous system.
By relaxing the smooth muscles, bendazole leads to an increase in the diameter of the arterial vessels, a decrease in the level of systemic arterial pressure, an improvement in blood flow in the peripheral arteries and vessels of the brain, and reduces the spasm of the hollow organs of the abdominal cavity.
After ingestion or injections of dibazol, the active substance quickly enters the systemic circulation and spreads in all tissues. Bendazole is able to penetrate the blood-brain barrier into the brain and spinal cord. In pregnancy, it enters the body of the developing fetus, during lactation - into breast milk. The active substance of the drug Dibasol is metabolized primarily in the liver, the products of decay are excreted in the urine by the kidneys.

Indications for use

The use of the drug Dibasol is indicated for several pathological conditions of the body:
    Spasm of coronary (cardiac) vessels in hypertensive disease or hypertensive crisis (a sharp and significant increase in blood pressure).
    Spasm of smooth musculature of the walls of hollow organs - excessive reduction of the stomach, which connects to the duodenum (pylorus), a significant increase in intestinal tone.
    The pathology of the nervous system is flaccid paralysis associated with impairment of the passage of nerve impulses in interneuronal, muscular-neuronal synapses (residual phenomena of the transferred poliomyelitis, facial paralysis, polyneuritis, flaccid paralysis).
Also, the drug helps reduce blood pressure with its intramuscular injection.

Contraindications for use

Use of tablets or solution for parenteral administration Dibazol is contraindicated in case of individual intolerance of the drug components. Also, its use is excluded during pregnancy at any time, during breastfeeding and some pathological conditions of the body:
    Renal failure with marked decrease in urinary function of the kidneys.
    The presence of an ulcer of the duodenum or stomach, from which bleeding periodically develops.
    Diabetes mellitus type 1 or 2.
    A marked decrease in muscle tone.
    Seizures convulsions.
Before you start using the drug, you need to make sure there are no contraindications.

Dosing and Administration

The method of application of the drug Dibazol depends on its dosage form. Tablets are taken internally for 2 hours before or after meals, after intake they are washed down with a sufficient amount of water. For adults and children over 12 years, the dosage is 20 or 60 mg 2-3 times a day, the average duration of therapy is 3-4 weeks (the dose and course of therapy the doctor sets individually depending on the nature and severity of the pathological process). In the treatment of neurological diseases, the dose of the drug is less - 5 mg once a day or every other day, only 5-10 times. Children dosage of the drug is lower, it depends on age:
    Up to 1 year - 1 mg once a day.
    From 1 year to 3 years - 2 mg once a day.
    4-8 years - 3 mg.
    9-12 years - 4 mg.
    Children over 12 years - 5 mg once a day.
The course of treatment of neurological disorders in children from 8 days to 2 weeks.
With parenteral administration intramuscularly injected 2-3 ml of 1% Dibazol solution 2-3 times a day, depending on the severity and severity of the pathological process. To stop (reduce the severity) of the hypertensive crisis intramuscularly inject 2-3 ml of the drug. With intravenous drip, the solution is diluted in 10-15 ml of isotonic sodium chloride solution (saline), the introduction into the vein is slow.

Side effects

In general, the drug Dibazol is well tolerated. Sometimes it is possible to develop allergic reactions in the form of itching, rashes on the skin, urticaria (a characteristic rash that resembles a nettle burn). With prolonged use of the drug, functional changes in heart function and electrocardiogram indices can be developed in the form of a reduction in cardiac output. When using high therapeutic doses, a feeling of heat develops, nausea, headache, dizziness, excessive sweating (hyperhidrosis).

special instructions

Before using Dibazol, you should carefully read the instructions for the drug and make sure that there are no contraindications. There are several special instructions that are important to pay attention to, they include:
    The drug should be used with caution elderly people, to monitor the level of systemic arterial pressure, cardiac activity (including electrocardiogram), functional activity of the liver and kidneys (biochemical blood test parameters are determined).
    To treat arterial hypertension (a symptomatic increase in blood pressure or hypertension), it is not recommended to use the drug for a long time.
    The use of dibazol with other antihypertensive drugs increases its therapeutic effect, which can lead to a marked decrease in blood pressure.
    When using tablets or a solution for parenteral administration of dibazol, it is desirable to refrain from work or activities related to the need for increased concentration of attention and speed of psychomotor reactions.
In pharmacies, Dibazol is released on prescription. You can not use it yourself or on the recommendation of third parties.

Overdose

If the recommended therapeutic dose is exceeded, the blood pressure drops below its normal value, dizziness, heat, nausea, vomiting develop. In case of taking the tablets, the stomach and intestines are washed, and intestinal sorbents are used. After exceeding the dosage for parenteral administration of the drug, symptomatic therapy is carried out, including cardiac glycosides and drugs that increase blood pressure.

Terms and conditions of storage

Shelf life of the drug Dibazol is 5 years from the date of manufacture, it must be stored in a dark, dry place inaccessible to children at an air temperature of +5 to +20 ° C.