Dusopharm tabs 50mg #90

Dusopharm instruction for use

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Composition

1 tablet contains:
Active ingredient: naftidrofuryl oxalate - 50 mg.
Excipients: lactose monohydrate; microcrystalline cellulose; wheat starch; copovidone; colloidal silicon dioxide; magnesium stearate; talc.
Shell composition: titanium dioxide; talc; magnesium stearate; macrogol 6000; methacrylic acid and ethyl acrylate copolymer; dye sunny sunset yellow E110.
Packaging - 30 pieces

pharmachologic effect

Dusopharm has a vasodilating effect, as a result of which it improves peripheral and cerebral circulation. It causes a decrease in peripheral vascular resistance and increases the minute volume of the heart, without having a significant effect on heart rate and blood pressure. The vasodilating effect of Dusopharm is the result of its direct myotropic, antagonistic to serotonin 5HT2 receptors and alpha adreno-blocking action. It has an M-holinoblokiruyuschee effect.
It has a positive effect on cellular metabolism, improving the utilization of oxygen and glucose. This action of the drug is due to its ability to increase ATP levels and inhibit the enzyme succinate dehydrogenase. It activates glucose utilization through the citric acid cycle and increases the conversion of succinic acid to fumaric acid. As a result, the resistance of cells (including the brain) to hypoxia increases.
In addition, Dusopharm reduces increased blood viscosity.

Dusopharm, indications for use

The recovery period of cerebral circulation disorders; peripheral circulatory disorders (intermittent claudication, Raynaud's disease, trophic ulcers).

Contraindications

    Increased individual sensitivity to the drug.
    Myocardial infarction (acute stage).
    Hypotension.
    Hemorrhagic stroke (acute stage).
    Epilepsy, increased convulsive readiness.
    Chronic heart failure stage II – III (NYHA stage III – IV - functional classification of heart failure in the New York Heart Association).
    Tachyarrhythmias.
    Age up to 18 years (efficacy and safety have not been established).
With care: angle-closure glaucoma; prostatic hyperplasia.

Dosage and administration

Inside Tablets are taken whole, with enough liquid (it is recommended to drink water).
For violations of cerebral circulation: a daily dose of 300 mg (2 tablets 3 times a day).
At disturbances of peripheral blood circulation: daily doses - 500–600 mg, divided into 3 doses.
Dusopharm is recommended for long-term oral therapy (up to 6 months). Dose adjustment for renal / hepatic failure is not required.

Use during pregnancy and lactation

Dusopharm does not have a teratogenic effect, but since special studies of its safety in pregnant women have not been conducted, it is recommended to prescribe the drug only in cases where the use of treatment for the mother outweighs the potential risk to the fetus.
It is not recommended to take the drug during breastfeeding.

Side effects

When taken orally in doses of 300 to 600 mg, Dusopharm is well tolerated as a whole.
Possible side effects: nausea, vomiting, pain in the epigastric region, intestinal colic, diarrhea, loss of appetite, headache, dizziness, sleep disturbances, a reversible increase in liver enzymes, ulcers of the gastric mucosa, allergic reactions.

special instructions

Dusopharm does not adversely affect psychomotor reactions and ability to drive a car. At the beginning of treatment, it is recommended to control the individual tolerance of the drug and to trace the possible hypotensive effect in the respective patients.
The drug contains lactose monohydrate, therefore it is not suitable for persons suffering from lactose deficiency, galactosemia or glucose-galactose malabsorption syndrome.
Patients with celiac disease (gluten enteropathy) should take into account that the composition of the tablet includes wheat starch.

Interaction

Strengthens the hypotensive effect of antihypertensive drugs. In this regard, it is recommended that more frequent monitoring of blood pressure at the beginning of the combined treatment with Dusopharm and antihypertensive drugs at the same time.

Overdose

Symptoms: increased severity of side effects, ventricular arrhythmia, anxiety, low blood pressure, bradycardia.
Treatment: gastric lavage, the appointment of activated carbon and laxatives, symptomatic treatment. There is no specific antidote.

Storage conditions

Shelf life - 3 years.
Store in a dry, protected from light and out of reach of children at a temperature not exceeding 25 ° C.

Terms of sell

You don't need a prescription to buy Dusopharm online.