Hyzaar tabs 50mg + 12.5mg #14

Hyzaar instruction for use

You can buy Hyzaar on this page online

Composition

Losartan potassium, hydrochlorothiazide, microcrystalline cellulose, aqueous lactose, pregelatinized starch, magnesium stearate, hydroxypropylcellulose, titanium dioxide, quinoline aluminum varnish, wax.

Form of issue

Hyzaar tablets in an oval-shaped oval-shaped shell in a blister pack in a cardboard box No. 14, 28.

pharmachologic effect

Diuretic, hypotensive.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active ingredients of the preparation Hyzaar forte have a synergistic antihypertensive effect, reducing arterial pressure to a greater extent than individually each of the components. Losartan potassium blocks the angiotensin II receptor, and hydrochlorothiazide is a diuretic.
The combination of hydrochlorothiazide and losartan reduces the severity of hyperuricemia caused by taking a diuretic, and also reduces the potentially high risk of cardiovascular disease in patients and death. Diuretic effect when taking the drug inside is manifested after 2 hours, the maximum effect occurs on average after 4 hours and lasts 6 to 12 hours.

Pharmacokinetics

Losartan is absorbed well and quickly from the digestive tract, metabolized in the liver during the "first passage". As a result of this process, a pharmacologically active metabolite and inactive metabolites are synthesized. Eating does not have a pronounced effect on the blood concentration profile revealed. The bioavailability of losartan is 33%. The maximum concentration in the blood is reached after 1 hour. High association with blood proteins - with albumin (99%). It is excreted with bile and with urine.
Hydrochlorothiazide as a result of hydroxylation partially forms a pharmacologically active metabolite. Through the BBB does not penetrate. The half-life is 15 hours. It is excreted in the urine within 24 hours, mostly unchanged.

Indications for use

    In the combined treatment of hypertension;
    In order to reduce the risk of cardiovascular morbidity and mortality in patients with left ventricular hypertrophy and hypertension.

Contraindications

High sensitivity to the drug, impaired kidney function, anuria, age to 18 years, liver function abnormalities, lactose intolerance, pregnancy, diabetes mellitus, lactation, bronchial asthma. With caution take when the water-electrolyte balance is violated against the background of vomiting and diarrhea.

Side effects

Local and general allergic reactions, diarrhea, cough, increased photosensitivity.

Hyzaar, instructions for use (Method and dosage)

In the treatment of arterial hypertension, Hyzaar take 1 tablet (50 / 12.5 mg) once a day for 2-4 weeks. Antihypertensive effect occurs in most cases within three weeks of taking the drug. If the therapeutic effect is absent, the daily dose should be increased to 2 tablets Hyzaar, taken in one session or go to receive one tablet Hyzaar forte (100 / 12.5 mg). Food intake does not have any effect on the effectiveness of the drug.

Overdose

Symptoms of overdose develop, as a rule, due to deficiency of electrolytes and dehydration against excessive diuresis and are manifested by tachycardia and marked decrease in blood pressure.

Interaction

With the simultaneous use of the drug Hyzaar or Hyzaar forte with ethanol, opioid analgesics, hydrochlorothiazide and barbiturates, the risk of developing hypotension increases dramatically. Taking a drug with insulin and hypoglycemic drugs may need to adjust the dosage of hypoglycemic drugs. It is possible to develop an additive effect when taking with other antihypertensive drugs. Do not take with drugs containing, as the risk of Li intoxication increases.

Terms of sale

You don't need a prescription to buy Hyzaar online.

Storage conditions

Do not freeze. Store at a temperature of 15-30 ° C.
Shelf life - 3 years.

Reviews of Hyzaar

Reviews about the drug are favorable. Patients note its high efficiency. "... I'm 48 years old, I suffer from hypertension. At the last appointment, the doctor prescribed Hyzaar pills for the night. I drank almost a month, the pressure stabilized. " Among doctors, the reviews about this combination of drugs are mostly positive. This drug allows you to improve the therapy of both arterial hypertension and associated diseases.