Lorista H tabs 100mg + 12.5mg #90

Lorista H instruction

Reed more and buy Lorista H pills here

To buy Lorista HD just contact us

Composition

One tablet of Lorista H contains:
    50 mg of potassium losartan;
    12.5 mg hydrochlorothiazide;
    magnesium stearate, MCC, lactose monohydrate, pregelatinized starch.
Tablets of the drug Lorista HD contain:
    100 mg of potassium losartan;
    25 mg nidrochlorothiazide;
    magnesium stearate, MCC, lactose monohydrate, pregelatinized starch.
The envelope consists of hypromellose, quinoline dye (yellow), talc, macrogol 4000 and titanium dioxide (E171).

Form of issue

Lorista's tablets are biconvex, oval, yellow (in some cases with a greenish tint) color, risk from one side; Lorista ND - oval tablets, having a biconvex form, color from yellow to greenish, without any risks.

pharmachologic effect

Has hypotensive effect.

Pharmacodynamics and pharmacokinetics

Both drugs (Lorista H and Lorista HD) are a combined drug that has an antihypertensive effect.
Losartan leads to an increase in renin activity, and also reduces the level of plasma aldosterone concentration. Reduces OPSS, the level of pressure in a small circle of circulation, has a diuretic effect, reduces afterload.
Losartan prevents the occurrence of hypertrophy of the myocardium, increases tolerance for physical exercises in those patients who suffer from heart failure. The use of losartan helps to reduce pressure. Does not cause withdrawal syndrome, does not affect the heart rate.
Effective in people of any sex, as well as older people (more than 65 years).
Hydrochlorothiazide has an antihypertensive effect due to the expansion of arterioles. The effect after taking is achieved after 1-2 hours, the maximum is observed after 4 hours, it lasts up to 12 hours. The hypotensive effect is achieved after taking in 3-4 days, but in order to achieve the optimal effect it is necessary up to 4 weeks.
When administered separately, the pharmacokinetics of hydrochlorothiazide and losartan is different from that when administered concomitantly.
Losartan is absorbed from the digestive tract. Serum concentration does not depend on the intake of the drug at the same time as food. Bioavailability is at the level of 33%. The maximum concentration is observed after 60 minutes. About 35% of the drug is excreted through the kidneys, 58% - with bile.
The digestibility of hydrochlorothiazide is about 60-80% after ingestion. The maximum concentration is from 1 hour to 5 hours. Quickly excreted through the kidneys, as it is not metabolized.

Indications for use

The drugs of Lorista H and Lorista ND have the same indications for use:
    reducing the risk of cardiovascular disease;
    reduction in mortality in patients with left ventricular hypertrophy and hypertension;
    arterial hypertension (combination therapy).

Contraindications

Both drugs should not be used in the following cases:
    anuria;
    deficiency of lactase;
    hyperkalemia;
    refractory hypokalemia;
    impaired renal or hepatic function;
    galactosemia;
    dehydration;
    arterial hypotension;
    pregnancy;
    syndrome of malabsorption of glucose or galactose;
    lactation;
    sensitivity to any component, to derivatives of sulfonamides;
    up to 18 years.
Use with caution when:
    diabetes mellitus;
    bilateral stenosis of the arteries of the kidneys;
    violation of water-electrolyte balance of blood (hypomagnesemia, hypochloraemic alkalosis, hyponatremia, hypokalemia);
    stenosis of the artery of the kidney;
    systemic blood diseases;
    hyperuricemia;
    allergic anamnesis;
    hypercalcemia;
    gout;
    bronchial asthma;
    simultaneously with NSAIDs.

Side effects

The result of taking this medication can be the following side effects:
    dizziness (non-systemic and systemic), insomnia, migraine, headache, fatigue;
    heart beat, dose-dependent orthostatic hypotension, tachycardia, in severe cases - vasculitis;
    cough, swelling of the nasal mucosa, pharyngitis, respiratory tract infections (upper sections);
    nausea, abdominal pain, diarrhea, vomiting, indigestion; in rare cases - hepatitis, an increase in the activity of hepatic enzymes, bilirubin, violations of the functionality of the liver;
    pain in the back, arthralgia, myalgia;
    purple Shenlaine-Genocha, anemia;
    weakness, chest pain, asthenia, peripheral edema;
    itching, anaphylactic reactions, urticaria, angioedema.
The intake of this drug can also affect laboratory parameters: hyperkalaemia, increased creatinine levels, urea, an increased concentration of hematocrit and hemoglobin.

Instructions for use Lorista H (Method and dosage)

The medicine is intended for oral administration. Possible combination with other drugs with antihypertensive effect. The intake of the drug is not dependent on food intake.
With arterial hypertension, a minimum dose of 1 tablet is prescribed. After a three-week course, the maximum hypotensive effect is achieved. To achieve a stronger effect, it is enough to take 2 tablets once a day, which is the maximum dose.
Patients with reduced BCC should take 25 mg of losartan per day. If the decrease in BCC occurred against the background of taking significant doses of diuretics, then before starting therapy with Lorista H, it is necessary to cancel the intake of diuretics.
The initial dose does not require correction in patients on dialysis, who suffer from renal failure (moderate degree) and elderly patients (over 65 years of age).
A daily dose of losartan of 50 mg is prescribed to reduce the risk of cardiovascular disease and mortality in those patients who are diagnosed with left ventricular hypertrophy or hypertension. If it was not possible to reduce the pressure when taking 50 mg, then it is necessary to combine losartan with hydrochlorothiazide (12.5 mg). If necessary, the use of losartan can be increased to 100 mg without changing the dose of hydrochlorothiazide. The maximum daily dose of the drug should not exceed once per 2 tablets.
Instruction for use Lorista ND: this drug is prescribed in the absence of therapeutic effect from the reception Lorista N. Lorista ND drug is taken in the same daily doses as Lorista N.

Overdose

An overdose of losartan has the following symptoms: significant pressure reduction, bradycardia, tachycardia. When symptoms of an overdose are found, treatment is recommended: symptomatic treatment, forced diuresis. Hemodialysis in this case is ineffective.
In case of an overdose with hydrochlorothiazide, such symptoms may appear: hypochloremia, hypokalemia, hyponatremia. In this case, symptomatic treatment is prescribed.

Interaction

Clinically significant interaction of losartan with digoxin, phenobarbital, hydrochlorothiazide, ketoconazole-valarine, erythromycin and cimetidine was not revealed.
The level of active metabolite is reduced when taking losartan with rifampicin and fluconazole. At the same time, such interaction was not clinically studied.
Hyperkalemia can result from a combination with potassium-sparing diuretics (triamterene, spironolactone, amiloride), potassium salts or additives containing potassium.
The efficacy of losartan may decrease due to the administration of NSAIDs and selective inhibitors of COX-2.
The intake of indomethacin can lead to a decrease in the hypotensive effect of lasothan.
Ethanol, narcotics and barbiturates when combined with hydrochlorothiazide may cause orthostatic hypotension.
Simultaneous taking of hypoglycemic agents (including insulin) may require correction of their dose.
Additive effect may manifest itself when combining treatment with other antihypertensive agents.
Violations of hydrochlorothiazide absorption may occur with preparations such as colestipol or colestyramine.
Hydrochorothiazide can enhance the effectiveness of muscle relaxants (tudokurarin).
The natriuretic, hypotensive and diuretic effect of hydrochlorothiazide can be reduced due to NSAIDs (including inhibitors of COX-2).
The laboratory results of studying the functions of parathyroid glands may be distorted due to the influence of hydrochlorothiazide on calcium metabolism.

Terms of sale

You don't need a prescription to buy Lorista H.

Storage conditions

The drug should be stored in a dark, not wet place. The maximum temperature is 30 ° C.
Shelf life - 5 years.

special instructions

A combination with other antihypertensive drugs is possible.
The initial dose for patients in the elderly is not specifically adjusted.
The intake of hydrochlorothiazide can lead to increased arterial hypotension and disrupt the water-electrolyte balance. It is also possible a violation of tolerance for glucose, a decrease in the level of excretion in the urine of calcium, which in turn can lead to a slight increase in the blood level of calcium.
Taking the drug in the second or third trimester during pregnancy can cause fetal death. The drug should be discontinued when pregnancy occurs. A newborn or fetus may have jaundice, a mother may have thrombocytopenia.
Admission of the drug in most patients does not affect the ability to perform tasks that require concentration. However, some patients at the beginning of treatment can observe a significant decrease in pressure, dizziness. Before starting such work, it is necessary to assess the condition after taking the medication.

Reviews about Lorista H

The average evaluation of the drug is 4.5 points (out of 5). Buyers note the effectiveness of the drug, its mild effect. Among the shortcomings - the need to take every day and the manifestation of side effects.
Positive reviews of doctors about the drug say its high efficiency. However, experts note that it must be taken strictly in doses determined by the doctor, in order to reduce the risk of side effects.
Reviews on Lorista HD coincide with reviews about Lorista H.