Lozap tabs 50mg #90

Lozap instruction for use

You can buy Lozap here

Composition

The composition of the drug Lozap includes losartan potassium (active ingredient), povidone, microcrystalline cellulose, croscarmellose sodium, mannitol, magnesium stearate, hypromellose, talc, macrogol, yellow dye, dimethicone (auxiliary substances).
INN Lozap Plus: Losartan + Hydrochlorothiazide.

Form of issue

Produced in the form of tablets, which covers a white film shell. Tablets of oblong form, biconvex. Blisters with tablets of 10 pcs. are sold in cardboard packs of 30, 60, 90 pcs.

pharmachologic effect

Lozap H is an antihypertensive drug. Its effect is based on the inhibition of binding of angiotensin 2 to AT1 receptors. As a result, a number of AT2 effects are leveled:
    arterial hypertension;
    liberation of renin and aldosterone, vasopressin, catecholamines;
    development of left ventricular hypertrophy.
Under the influence of the medicine there is no blockage of the angiotensin-converting enzyme, therefore bradykinin does not accumulate and no effect on the kinin system is made.Active metabolite Lozapa is formed during biotransformation and has an antihypertensive effect on the body. Therefore, the drug is a prodrug.
The drug equally affects patients, regardless of their age, race or gender.

Pharmacodynamics and pharmacokinetics

Lozap is an antihypertensive drug, a specific antagonistreceptor of angiotensin II. It reduces the peripheral resistance of blood vessels, reduces the level of adrenaline and aldosterone in the blood. Under its influence, the pressure in the small circle of blood circulation decreases, the diuretic effect develops, post-loading decreases. Lozap prevents hypertrophic processes of the myocardium, promotes an increase in tolerance to physical exertion in people with heart failure.
The maximum hypotensive effect after a single dose of the drug is observed after 6 hours, after which it gradually decreases over a period of 24 hours. With systematic treatment, the maximum effect (decrease in blood pressure) occurs three to six weeks after the initiation of therapy.
It should be taken into account that in people who have cirrhosis of the liver, the concentration of the active substance (losartan) in the blood plasma increases markedly. Therefore, such patients are assigned a special, reduced dosage.
Absorption from the human gastrointestinal tract occurs quickly. Bioavailability of the drug is about 33%. After oral administration, the highest concentration in the plasma is present after one hour. The greatest concentration of the metabolite of the drug is observed after 3-4 hours. The half-life of losartan is 2 hours, the active metabolite is 9 hours. 35% of the drug is excreted from the body with urine, about 60% - through the intestine.

Indications for use

Lozap is used in such cases:
    arterial hypertension;
    heart failure of a chronic form (the drug is included in a combination treatment, used to treat patients with intolerance to ACE inhibitors, or when their ineffectiveness is noted);
    the need to reduce the risk of cardiovascular diseases (including stroke) in people suffering from hypertension and left ventricular hypertrophy;
    development of diabetic nephropathy in patients with type 2 diabetes and arterial hypertension.
Indications for use Lozap Plus are the same. However, it has a combined composition, therefore indications for the use of the drug Lozap Plus include conditions with arterial hypertension, which require additional treatment with diuretics.

Contraindications

Contraindications for treatment are:
    intolerance of the components that make up the drug;
    hyperkalemia;
    arterial hypotension;
    pregnancy and lactation;
    children and adolescence (up to 18 years);
    dehydration.

Side effects

Most often, no side effects are observed with the drug. With the development of side effects, their character is transient, therefore, drug cancellation, as a rule, is not required. Seldom can disturb the following phenomena:
    Functions of the sensory and nervous system: fatigue, headaches, dizziness, insomnia, asthenia. Less than 1% of cases develop drowsiness, anxiety, memory disorder, depression, paresthesia, tremor, hypoesthesia, migraine, hearing, vision, taste.
    Functions of the respiratory system: symptoms of upper respiratory tract infections. Less than 1% of cases develop bronchitis, dyspnea, rhinitis.
    Functions of the digestive system: abdominal pain, nausea, diarrhea. Less than 1% of cases are dry mouth, gastritis, vomiting, toothache, flatulence, constipation.
    Functions of the musculoskeletal system: pain in the back, extremities, chest; cramps, myalgia. Less than 1% of cases are arthritis, arthralgia, pain in the shoulder, knee.
    Functions of the cardiovascular system: dose-dependent hypotension, tachycardia or bradycardia, angina pectoris, arrhythmia, anemia.
    Functions of the genitourinary system: less than 1% of the cases the drug has a negative effect on potency, urinary tract infections, renal impairment.
    Also, there is rarely a dry skin, increased sweating, allergic reactions, hyperkalemia.

Instructions for use Lozap (Method and dosage)

The drug is taken orally, there is no dependence on the intake of food. Tablets should be taken once a day. Patients with hypertension take the drug at 50 mg per day. To achieve a more noticeable effect, the dose is sometimes increased to 100 mg. How to take Lozap in this case, the doctor gives recommendations individually.
Instruction for Lozap N provides that patients with heart failure take the medicine at 12.5 mg once a day. Gradually the dose of the drug is doubled with an interval of one week until it reaches 50 mg once a day.
Instructions for use Lozap Plus provides for the intake of one tablet once a day. The largest dose of the drug is 2 tablets per day.
If a person takes in parallel high doses of diuretic drugs, the daily dose of Lozap is reduced to 25 mg.
Elderly people and patients with impaired renal function (including those who are on hemodialysis) to adjust the dosage is not necessary.

Overdose

When taking too large doses of the drug in a person may manifest tachycardia or bradycardia, as well as severe hypotension. Treatment involves removing the drug from the body and applying symptomatic therapy.

Interaction

Taking the drug simultaneously with rifampicin and fluconazole leads to a decrease in the content of the active metabolite in the blood plasma.
It should be borne in mind that Lozap can increase the effect of other drugs antihypertensive effect: adrenoblocator, diuretics, IAKF. Patients with dehydration, which arose as a result of treatment with large doses of diuretics, may notice a marked decrease in blood pressure after taking Lozap.
In the case of simultaneous use with potassium preparations, diuretic potassium-sparing agents should constantly monitor the level of potassium, since there is a risk of developing hyperkalemia.
The hypotensive effect of the drug decreases after taking indomethacin and other NSAIDs.
Clinically pronounced interaction with hydrochlorothiazide, digoxin, cimetidine, warfarin, phenobarbital and erythromycin is not noted.

Terms of sale

The prescription is not needed to buy Lozap online.

Storage conditions

Keep the medicine in a dry place, protected from direct rays of light. The air temperature should not be above 30 degrees Celsius.
Shelf life of the drug is 2 years.

special instructions

The medicine for pressure Lozap with caution is prescribed to people who previously received large doses of diuretics.
Before taking the pill against pressure, it is necessary to exclude the presence of liver diseases. Patients with liver pathologies should take pills from Lozap's increased pressure in reduced doses.
The drug is administered with caution to people suffering from stenosis of the artery of a single kidney, as well as bilateral stenosis of the renal arteries.
Under the influence of the drug, the ability to drive and interact with complex mechanisms remains.

Lozap or Lorista - which is better?

The active substance of the drug Lorista is the same as that of Lozap. Lorista is assigned to patients suffering from hypertension and chronic heart failure. At the same time, the cost of Lorist's drug is lower. If the price of Lozap (30 pcs.) Is about 280 rubles, then the cost of 30 tablets of Lorist's drug is 130 rubles. However, the analogue can be used only after consulting with the doctor and after the abstract is carefully read.

Children

The efficacy and safety of use in children have not been established, so the drug is not used to treat children.

With alcohol

Do not take alcohol at one time with medication. Joint use of alcoholic beverages and Lozapa increases the concentration of active ingredient in the body, causing the tablets to cause negative side effects.

In pregnancy and lactation

Do not undergo Lozap during pregnancy. When treating in the second and third trimesters with drugs that affect the renin-angiotensin system, defects in fetal development and even death may occur. As soon as pregnancy occurs, the drug should be discontinued immediately.
If Lozap should be taken during lactation, breast-feeding should be stopped immediately.

Reviews

Reviews for Lozap Plus and Lozap indicate that in most cases, drugs effectively reduce blood pressure and have a positive effect on the health of people with cardiovascular disease. Patients visiting a specialized forum to leave feedback on Lozap 50 mg, note that as side effects, sometimes coughing, dry mouth, hearing impairment. But in general, patients' reviews of the drug are positive. At the same time, the doctors' testimonies testify that the drug may not be suitable for all people suffering from hypertension. Therefore, initially it should be taken under the clear supervision of a specialist.