Presartan tabs 50mg #30

Presartan instruction for use

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Composition

Losartan potassium, dried starch, microcrystalline cellulose, silicon dioxide, sodium starch glycolate, magnesium stearate, methylene chloride, talc purified, isopropanol, red dye.

Form of issue

Tablets 25 and 50 mg in a film shell of round shape, biconvex, pink in strips of 14 pieces in carton No. 28, 30.

pharmachologic effect

Antihypertensive.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug with hypotensive effect, refers to drugs that are specific blocker of angiotensin receptors (type AT1). Do not suppress the enzyme (kinase II), which destroys bradykinin. Presartan reduces the concentration in the blood of aldosterone and norepinephrine, OPSS, AD, reduces postnagruzku, pressure in the "small" circle of circulation, has a diuretic effect. It inhibits the development of myocardial hypertrophy. In patients with CHF increases resistance to physical activity.
After a single dose of Presartan, the hypotensive effect reaches its maximum after 6 hours, and gradually decreases over the next 24 hours. The maximum hypotensive effect appears on average a month after the start of treatment with the drug.

Pharmacokinetics

Losartan is rapidly absorbed from the digestive tract. High degree of communication with blood proteins (92-99%). Bioavailability is about 33%. The elimination half-life is 2 hours. Do not cumulate in the body, is excreted from the body with urine and bile.

Indications for use

    In the treatment of hypertension;
    In the therapy of IHD with symptoms of heart failure.

Contraindications

High sensitivity to the drug, childhood, hyperkalemia, pregnancy and lactation, dehydration, hypotension.

Side effects

The drug is well tolerated by most patients. In rare cases: indigestion, diarrhea, headache, dizziness, sleep disturbance, local allergic reactions, cough, hyperkalemia, puffiness, myalgia.

Presartan, instructions for use (Method and dosage)

Presartan is taken regardless of the meal, once a day. In the treatment of hypertension, the recommended daily dose of 50 mg, which, if necessary, can be increased to 100 mg. In case the patient takes high doses of diuretics, the dosage should be reduced to 25 mg per day.
For the treatment of CHF, the initial daily dose is 12.5 mg taken at a time, then, at a weekly interval, the dose is doubled (12.5, 25, 50 mg). The maintenance dose is 50 mg per day. To enhance the hypotensive effect, it is recommended to prescribe Presartan H (Lozartan with an antihypertensive agent).

Overdose

In rare cases - tachycardia, arterial hypotension.

Interaction

Simultaneous reception of the drug with drugs containing potassium (potassium preparations, potassium-sparing diuretics) increases the risk of hyperkalemia. The combination of taking the drug with diuretics can cause a sharp drop in blood pressure. Joint intake of Presartan with NSAIDs helps to reduce the hypotensive effect of the drug. At simultaneous reception of a preparation with other antihypertensive drugs the mutual hypotensive action amplifies.

Terms of sale

You can buy Presartan without a prescription.

Storage conditions

At temperatures up to 25 ° C.
Shelf life - 36 months.

Reviews of Presartan

Patients' feedback about the drug is positive. Presartan is one of the drugs of combined treatment of hypertension and ischemic heart disease. "… I am 70 years old. Of these, I have been suffering from hypertension for almost 25 years. I tried various treatment regimens. Recently, Presartan was added to the treatment. The nurse explained how to take Presartan, and I've been drinking it for almost three weeks. The result is good. " Doctors also note that the addition of the drug in the treatment of hypertension and coronary artery disease allows to achieve a long and stable antihypertensive effect, in the absence of episodes of hypotension, to achieve target blood pressure levels.