Cozaar tabs 50mg #14

Cozaar user manual

Reed more and buy Cozaar online

Composition

The drug release in two doses of 50 or 100 mg of active ingredient + losartan potassium, microcrystalline cellulose, pregelatinized starch, giproloza, titanium dioxide, hypromellose, lactose monohydrate, magnesium stearate, carnauba wax.

Form of issue

Tablets dosage 50 mg of white, oval-shaped, with the mark 952 and engraved, coated with a film coating. Tablets with an active ingredient content of 100 mg engraved 960, a drop-shaped form, no risks.
The medicine is produced in blisters and cardboard boxes of 7, 14 or 28 pieces.

pharmachologic effect

Cozaar has hypotensive effect.

Pharmacodynamics and pharmacokinetics

The active ingredient is an angiotensin 2 receptor antagonist. The substance completely blocks all the effects of antitoxin, regardless of the way the enzyme was synthesized, or from which source it was obtained. As you know, it is angiotensin 2 (a powerful vasoconstrictor) is an important factor in the development of arterial hypertension. In addition, the active substance does not act as an antagonist of angiotensin.
The agent enters into a selective connection with specific AT1-receptors, without affecting the receptors of other ion channels and hormones. Losartan has no effect on kininase 2 and bradykinin. It is proved that the active substance of the drug is not the cause of edema.
After taking the drug, the inverse relationship between the suppression of angiotensin 2 and renin secretion disappears; on the contrary, the activity of the APP increases.
After therapy with the drug for 6 weeks, the concentration of angiotensin 2 increases by 2-3 times. There is an effective blockade of specific receptors, which fully manifests itself within 14-48 days after the start of the drug.
It is proved that the drug has no effect on vegetative NS. and reflexes, the concentration of sugar in the blood. Lozartan strongly pharmacokinetically differs from ACE inhibitors, it blocks the effects of angiotensin 1 and 2, without affecting bradykinin (ACE inhibitors act in the opposite way).
With an increase in the dosage of the drug, its hypotensive effect increases.
When carrying out the study with healthy men, after taking 100 mg of the drug, while observing a low-salt or high-salt diet, the glomerular filtration rate, the filtration fraction and the kidney function as a whole did not change. However, the intensity of renal excretion of uric acid and the content of sodium in the urine increased.
In women in menopause and the period after, suffering from high blood pressure, with a daily intake of 50 mg of medication during the month, the level of PG did not change.
In clinical trials, whose goal was to assess the dependence of well-being, mortality and heart failure rate in patients with CSN from daily dosage of losartan, it was proved that the drug at a dosage of 150 mg is much more effective than 50 mg. The research was conducted for 4 years.
After getting the tablets in the digestive tract, the active component of Cozaar is absorbed well and quickly, penetrates into the systemic bloodstream and is metabolized (14%) in liver tissues. Losartan forms the active (carboxylated) and inactive (N-2-tetrazole-glucuronide) metabolites. Biological availability is about 30%. The maximum concentration of Losartan is observed after 60 minutes, its metabolites after 3.5 hours. Pharmacokinetic parameters do not depend on food intake.
The drug has a very high degree of binding to plasma proteins - about 99%. The active substance does not penetrate the blood-brain barrier.
The medicine is excreted in the form of metabolites or unchanged in kidney and feces, for 120 minutes and 5-6 hours, respectively. When taking 100 mg of the drug per day, it is not inclined to accumulate in the body.
Pharmacokinetic parameters do not depend on age. However, in women the plasma concentration of the active substance is 2 times higher than that of men.
In patients with liver disease (with cirrhosis) plasma concentrations are several times higher than in healthy people.
When the creatinine clearance is more than 10 ml per minute, the indices of the drug are not significantly different in persons not in hemodialysis. The agent is not excreted from the body during hemodialysis.

Indications for use

Cozaar appoint:
    persons suffering from hypertension;
    for kidney protection in type 2 diabetes mellitus with proteinuria;
    to reduce the risk of developing a heart attack (stroke, heart attack) or mortality in patients with left ventricular hypertrophy and elevated blood pressure;
    with chronic heart failure, with intolerance or insufficient effectiveness of ACE inhibitors;
    to reduce the incidence of CRF (in the terminal stage, if a transplant or hemodialysis is required).

Contraindications

The medicine is contraindicated:
    when allergic to its components;
    with lactose intolerance, glucose-galactose malabsorption syndrome or lactase deficiency;
    Persons suffering from severe liver disease;
    under the age of 18;
    in combination with Aliskiren;
    pregnant and lactating women.
Care should be taken:
    with bilateral stenosis of the renal arteries or stenosis of the arteries of the kidney (if the patient has one kidney);
    patients with severe heart failure, especially in combination and kidney failure;
    with ischemic heart disease or cardiac arrhythmia;
    after kidney transplantation;
    with mitral or aortic stenosis;
    patients with cerebrovascular diseases, Quinck's edema, including in the anamnesis;
    with a reduced BCC.

Side effects

Patients with elevated blood pressure are usually well tolerated. Adverse reactions are transitory in nature, they go away with time, drug cancellation is not required.
The most frequently manifested: dizziness, rash on the skin, orthostatic reactions.
Also possible:
    sleep disorders, headache, asthenia;
    heart palpitations, pain in the chest region, weakness, fatigue, edema along the periphery;
    tachycardia, pain in the epigastric region;
    indigestion, nausea, diarrhea;
    muscle spasms, back pain;
    rhinitis, cough, sinusitis, pharyngitis and other diseases of the upper respiratory tract caused by infection.
In type 2 diabetes, the most common are: weakness, dizziness, hyperkalemia, arterial hypotension.
The frequency and nature of adverse reactions depend on the daily dosage the patient takes. Thus, with the intake of 150 mg of Cozaar per day, hyperkalaemia, renal insufficiency, a decrease in blood pressure, an increase in the level of creatinine, potassium and urea in the blood were more frequent.
During the period after registration of the drug, the following side effects were identified:
    vomiting, hepatic insufficiency, hepatitis;
    thrombocytopenia, myalgia;
    dysgeusia and migraine;
    anemia, arthralgia;
    decreased libido and impotence;
    urticaria, redness and rashes on the skin, skin sensitivity to light.

Instructions for use Cozaar (method and dosage)

The drug is prescribed inside, regardless of food.
The dosage and the regimen should be determined by the attending physician, while the medicine can be combined with other drugs from arterial hypertension.

Instructions for use Cozaar

With elevated blood pressure, the initial dosage is 50 mg per day.
After 21-42 days after the start of treatment, the drug reaches its maximum efficiency.
If necessary, the dosage can be increased to 100 mg per day.
For patients in whom elevated blood pressure is accompanied by left ventricular hypertrophy or type 2 diabetes, the initial dosage is also 50 mg per day (then it is increased to 100 mg).
People with CHF in the first stages of treatment can take 12.5 mg of the drug once a day. Dosage is increased every 7 days (25 mg, 50 mg, 100 mg and 150 mg) according to the condition of the patient.
With a reduced volume of circulating blood (after taking diuretics), the initial dosage is 25 mg per day.
Also, dose adjustment is necessary for severe liver diseases.

Overdose

There is no evidence of drug overdose. It is assumed that taking large doses of the drug will lead to a strong decrease in blood pressure and tachycardia.
As a treatment, he carries out symptomatic and supportive therapy. Hemodialysis is ineffective.

Interaction

The medicine can not be combined with Aliskiren in diabetes mellitus or with kidney failure.
When combined selective inhibitors of COX-2, non-steroidal anti-inflammatory drugs with Losartan, the effectiveness of both groups of drugs decreases.
The combination of Cozaar with Spironolactone, Amyloride, Triamteren and other potassium-sparing diuretics leads to an increase in the level of potassium in the blood.
The medicine can be combined with Digoxin, Cimetidine, Phenobarbital, hydrochlorothiazide, Warfarin, Erythromycin, Ketoconazole.
It is known that Rifampicin is able to reduce the plasma concentration of this drug.
Fluconazole reduces the c-tion of the drug in the blood.
Losartan makes it difficult to remove lithium from the body.
With special care should be combined medicine and PNVS, it can lead (especially in elderly people, patients with dehydration) to increase the burden on the kidneys. Changes are reversible, usually occur after the withdrawal of one of the drugs.

Terms of sale

You don't need a prescription to buy Cozaar online.

Storage conditions

In a cool, dark place, away from small children.
Shelf life - 3 years.

special instructions

The drug is not effective for reducing the incidence of heart attacks for patients of the Negroid race. In this case, atenolol was more effective. This leads to the conclusion that ACE inhibitors and angiotensin antagonists are less effective in patients of the Negroid race.
The medicine has no sense in prescribing for primary hyperaldosteronism, it does not reduce blood pressure.
Due to the fact that some of the side effects can affect the speed and accuracy of psychomotor reactions, during drug treatment it is recommended to refrain from driving.

In pregnancy and lactation

The drug is strictly forbidden to take during pregnancy. It should be changed for other antihypertensive drugs.
Whether the remedy is allocated to breast milk is not known. Therefore, during treatment by Cozaar, breastfeeding should be discontinued.

Reviews about Cozaar

On the online forums about the drug respond very well. With a systematic intake of the drug normalizes the pressure and rarely causes side effects. It is convenient that his reception is not associated with eating.
"A normal drug, but it did not help right away, but only somewhere for the third week of admission";
"After the operation I have been taking Cozaar for a week. The pressure dropped from 220 \ 116 to 130 \ 87. Side effect is weakness, but I sin on the narcosis transferred. Before that I tried other medications - they did not help me. "