Indap caps 2.5mg #30

Indap instruction for use

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Composition

One capsule contains the active substance indapamide in an amount of 2.5 mg.
Additional components are: magnesium stearate, gelatin, microcrystalline cellulose, starch, titanium and silicon dioxide, lactose monohydrate, dye.

Form of issue

Available in capsule form.

pharmachologic effect

Vasodilator, diuretic.

Pharmacodynamics and pharmacokinetics

The main component is indapamide. The drug has an antihypertensive effect. Pharmacological properties of the drug Indap are similar to thiazide diuretics, the principle of the effect is based on the violation of the reabsorption of sodium ions in the cortical section in the loop of Henle. The drug increases the excretion of sodium, chlorine, magnesium, and potassium ions into the urine. The drug selectively blocks the "slow" calcium channels, reduces the OPSS, increases the elasticity of the vascular walls.
Indap does not affect the level of lipids in blood plasma, carbohydrate metabolism, which is important in the treatment of patients with diabetes mellitus. Under the influence of Indap, the sensitivity of the vascular wall to the action of angiotensin-2, noradrenaline, decreases.
The drug stimulates the production of prostacyclin PgI2, PgE2, reduces the synthesis of stable oxygen and free radicals. High dosages of the drug cause increased diuresis, but do not affect the degree of blood pressure drop.
With repeated, stable application, the effectiveness of the drug is recorded in the second week.

Indications for use Indap

From what tablets?

The drug is prescribed for arterial hypertension.

Contraindications

The drug is contraindicated in hypokalemia, anuria, pathology of the renal system, severe liver damage, with intolerance to Indapamide.
The drug is not prescribed for decompensated diabetes mellitus with ketoacidosis, with acute disruption of cerebral circulation, with galactosemia, lactose intolerance, impaired absorption of galactose or glucose.
In ascites, moderate renal / hepatic insufficiency, water-electrolyte balance disorders, hypotenemia, QT interval prolongation, CHF, CHD, hyperuricemia, breastfeeding, hyperparathyroidism, urate nephrourolythiasis, gout, the drug Indap is administered with caution.

Side effects

The severity of side effects largely depends on the dosage of the drug.
Digestive system: dyspepsia, stool disorders, epigastric pain, nausea, dry mouth, vomiting, gastralgia, eating disorders.
Nervous system: dizziness, nervousness, asthenia, headaches, vertigo, drowsiness, dizziness, depression, insomnia, agitation, irritability, anxiety, tension, nervousness, lethargy, lethargy, asthenia, fatigue, malaise, spasm of muscle fibers.
Organs of the senses: visual impairment, conjunctivitis.
Respiratory system: pharyngitis, cough, rhinitis.
Cardiovascular system: palpitation, arrhythmias, hypokalemia, orthostatic hypotension.
Urinary system: polyuria, nocturia, frequent infections of the urinary system.
Flu-like syndrome, back pain, infectious lesions, pain in the chest, increased sweating, rhinorrhea, libido / potency disorders, paresthesia in the limbs, weight loss, allergies, hyponatremia, hyperglycemia, hyperuricemia, hypochloraemia, glucosuria, hypercreatininaemia, hypochloraemia, increased levels of nitrogen in urea, hypercalcemia.

Indap, instructions for use (Method and dosage)

The medicine is taken in the morning, inside.
The initial dosage for arterial hypertension is 1.25-2.5 mg per day (non-protracted form of the drug), or 1.5 mg of the prolonged form of the drug per day.
In the case of failure to achieve full efficacy in 4-8 weeks, a drug with a different mechanism of action is added to the treatment regimen.
According to the instructions for use, an increase in dosage is considered impractical in view of an increase in the severity of side effects and lack of achievement of the target blood pressure level.

Overdose

It is manifested by disorders in the digestive system, respiratory depression, excessive drop in blood pressure, weakness, vomiting, water-electrolyte disorders, nausea. In persons with cirrhosis of the liver, a hepatic coma is recorded.
It is required timely symptomatic therapy, gastric lavage, correction of water-electrolyte balance. Specific antidote is not developed.

Interaction

Indap increases the level of lithium ions in the blood, reducing its excretion through the renal system. Lithium is able to exert a pronounced nephrotoxic effect. Due to dehydration of the body there is an increase in the damaging effect on the kidneys when using contrast iodine-containing medications. Before performing the procedures it is recommended to restore the loss of water. Indap reduces the effect of indirect anticoagulants.
With the use of nondepolarizing muscle relaxants, there is an increase in blockade in neuromuscular transmission. Laxatives, amphotericin B, tetracosactide, glucocorticosteroids, cardiac glycosides, thiazide, loop diuretics, saluretics increase the likelihood of hypokalemia. The risk of digitalis intoxication increases with simultaneous appointment of cardiac glycosides. Admission with calcium causes hypercalcemia, Metformin - lactic acidosis.
Pentamidine, sultopride, erythromycin, astemizole, vincamine, terfenadine, disopyramide, quinidine, antiarrhythmics, brethilia tosilate, amiodarone, sotalol due to synergistic effects can lead to the development of "fever" type arrhythmia. Adrenostimulators, terakozaktid, glucocorticosteroids reduce the severity of hypotensive effect, baclofen - vice versa. The risk of developing acute renal failure, arterial hypotension significantly increases with the use of ACE inhibitors.
Orthostatic hypotension can be observed with the appointment of neuroleptics, tricyclic / imipramine antidepressants. Hypercreatininaemia is recorded with the administration of cyclosporine.

Storage conditions

In a dry, dark place, protected from children, at a temperature of 15-25 degrees Celsius.
Shelf life not more than three years.

special instructions

Patients with hyperaldosteronism, with the intake of laxatives, cardiac glycosides, regular monitoring of the level of potassium, creatinine is strongly recommended. Systematic intake of the drug Indap requires monitoring the levels of magnesium, sodium, potassium in the blood plasma, residual nitrogen, uric acid, sugar because of the risk of electrolyte disturbances. More careful monitoring is indicated for patients suffering from cirrhosis of the liver, ascites due to a high risk of metabolic alkalosis, increased severity of encephalopathy, CHF, CHD. Patients with a high QT interval on the ECG are at high risk. It is mandatory to conduct an analysis of the level of potassium in the body during the first week of therapy. With previously undiagnosed hyperparathyroidism, it is possible to increase the level of calcium on the background of the use of the drug. Patients with diabetes mellitus are extremely important to control the glucose level when taking the drug Indap, especially with severe hypokalemia. Reduction of glomerular filtration, development of acute renal failure is possible as a result of significant dehydration. At the beginning of treatment, it is necessary to closely monitor the work of the kidneys, if necessary, to compensate for the loss of fluid. Against the background of the use of the drug, a positive doping test can be registered. The indap can cause an exacerbation of systemic lupus erythematosus. The safety and effectiveness of Indap in children is not established.

Feedback on Indap

According to the doctors' reviews, the Indap tablets effectively reduce pressure and remove swelling. Be sure to drink the medicine course. It should be remembered that the drug improves the pressure situation not permanently.
There are a large number of contraindications and side effects.