Indapamide tabs 2.5mg #30

Indapamide user manual

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Composition

One tablet in a film shell contains 2.5 mg of active substance indapamide hemihydrate.
Excipients: colloidal silica, pregelatinized starch, magnesium stearate and MCC.
Sheath composition: macrogol 6000, lactose monohydrate, hypromellose, titanium dioxide (E171).

Form of issue

    in tablet form for 2.5 mg - Indapamide;
    in the form of capsules of 2.5 mg - Indapamide Verte;
    in tableted form of 1.5 mg - Indapamid Retard and Indapamide MB Stade.
Packing - 10 pieces in a contour pack of PVC film or foil with molded cells. In a cardboard bundle 3 packages (blisters). Another form of release is possible. In the package with the package is enclosed the instruction with an explanation, from what the medicine Indapamide is applied, what contraindications and side effects exist.

pharmachologic effect

The drug belongs to the category of diuretics and hypotensive drugs.

Pharmacodynamics and pharmacokinetics

According to its pharmacological properties, the drug is close to thiazide diuretics. Increases the concentration of sodium, chlorine, potassium and magnesium ions in the urine. Increases the elasticity of the walls of the arteries, gently reduces the resistance of peripheral vessels. Has no effect on carbohydrate metabolism and lipid content in the blood, helps to reduce left ventricular hypertrophy of the heart.
Indapamide is a stimulant for the production of prostaglandin E2, it has a significant effect on the production of free oxygen radicals.
The medicine begins to act 30 minutes after the intake (bioavailability is about 93%), the therapeutic effect persists for 24 hours. The maximum concentration in the blood is 12 hours after the dissolution of the tablet in the digestive tract. The elimination half-life is 18 hours. Eating can prolong the absorption time a little, but the drug, however, is absorbed completely. The kidneys produce up to 80% of the substance in the form of metabolites, the intestine - up to 20%.

Indications for Indapamide

Arterial hypertension (hypertension).
Indications for the use of Indapamide Retard, Indapamid Teva and Indapamide MB Stade, as well as other forms of medication - hypertensive disease of moderate severity, chronic heart failure.

Contraindications

Knowing from what the Indapamide tablets are applied, it is also important to study all contraindications, among which absolute are:
    renal and hepatic impairment;
    allergic reactions to sulfonamide derivatives;
    age to 18 years;
    anuria;
    diabetes;
    pregnancy and the period of breastfeeding;
    pre-infarction state.

Side effects

The drug, as a diuretic, can lead to a decrease in potassium in the blood serum, a decrease in the concentration of sodium, which leads to dehydration of the body. In this regard, such symptoms as dry mouth, constipation, nausea, headache, allergic reactions are possible.
Rare side effects - heart rhythm disturbances, hemolytic anemia.

Indapamide tablets, instructions for use

Tablets are taken strictly according to the instructions - once a day, preferably in the morning, one tablet or capsule.
The drug can be combined with other antihypertensive drugs, but how to take the drugs in different combinations, can only determine the attending physician.
Instruction for the use of Indapamide Retard and instructions for the use of Indapamide MB Stade (manufactured in Germany) do not contain differences regarding the conditions for taking and dosage. However, the Retard preparation is characterized by a longer, and at the same time milder action of the reagent, due to the delayed release of the active substance.
How long you can take Indapamide, the doctor decides, considering the stage of hypertension, but in medical practice this means refers to medicines that are prescribed for a long period of time (including life time).

Overdose

The toxicity of the drug manifests itself at a dose of 40 mg. Signs of poisoning - drowsiness, nausea, vomiting, a sharp decrease in pressure, dry mouth.
Urgent measures - gastric lavage, restoration of electrolyte balance, rehydration (only in a hospital).

Interaction with other drugs

    Antidepressants and antipsychotics increase the hypotensive effect, increase the likelihood of developing orthostatic hypotension.
    Aluretics, cardiac glycosides, laxatives increase the risk of potassium deficiency.
    Erythromycin can lead to the development of tachycardia with ventricular fibrillation.
    Nonsteroidal anti-inflammatory drugs, glucocorticosteroids reduce the hypotensive effect.
    Preparations containing iodine can lead to a deficiency of fluid in the body.
    Cyclosporine promotes the development of hypercreatininaemia.

Terms of sale

You can buy Indapamide without prescription.
Shelf life - 3 years (the expiration date is indicated on the package).

Storage conditions

The drug is listed in B. It is recommended to store in a dry place, at a temperature of no higher than 25 ° C. Keep away from children!

Reviews of Indapamide

Reviews of Indapamide Retard, in general, indicate a high effectiveness of the drug. Hypertension, in general, is well tolerated. Reviews of doctors and patients, as well as a forum where the issues of treatment of hypertension are discussed, convincingly confirm this fact.
Side effects are rare, and are characterized by poor expression. Many people with a diagnosis of "hypertension" take pills for life.