Indapamide MB tabs 1.5mg #30

Instruction for Indapamide MB

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Composition

1 tablet contains:
Active ingredient: Indapamide - 1.5 mg;
Excipients: hypromellose (hypromellose 4000) - 42–78.4 mg; lactose monohydrate - 168.5–132.1 mg; colloidal silicon dioxide (aerosil) - 1 mg; magnesium stearate - 2 mg;
Shell: hypromellose (hydroxypropylmethylcellulose) - 5.94 mg; macrogol (polyethylene glycol 4000) - 1.29 mg; talc - 0.462 mg; titanium dioxide - 1.29 mg; dye tropeolin O - 0,018 mg.
Packaging - 30 pieces

pharmachologic effect

Indapamide MB is an antihypertensive (diuretic, vasodilator). Pharmacologically similar to thiazide diuretics (impaired Na + reabsorption in the cortical segment of the loop of Henle). Increases urinary excretion of Na +, Cl - ions and, to a lesser extent, K + and Mg 2+ ions. Possessing the ability to selectively block "slow" calcium channels, it increases the elasticity of artery walls and reduces total peripheral vascular resistance. Helps to reduce left ventricular hypertrophy. Does not affect the content of lipids in the blood plasma (TG, low-density lipoprotein, high-density lipoprotein); does not affect carbohydrate metabolism (including in patients with concomitant diabetes). It reduces the sensitivity of the vascular wall to noradrenaline and angiotensin II, stimulates the synthesis of prostaglandin E2, reduces the production of free and stable oxygen radicals. The antihypertensive effect develops by the end of the first week, persists for 24 hours against a single dose.

Indapamide MB, indications for use

Arterial hypertension.

Contraindications

Hypersensitivity to Indapamide MB, other sulfonamide derivatives or other components of the drug, decompensation of renal function (anuria) and / or liver (including with encephalopathy), hypokalemia, simultaneous administration of drugs prolonging the QT interval, pregnancy, lactation, age to 18 years (efficacy and safety not established).

Dosage and administration

Tablets are ingested 1.5 mg 1 time per day (in the morning).
With insufficient severity of the hypotensive effect after 2 weeks of treatment, the dose is increased to 5-7.5 mg / day.
Maximum dose: 10 mg / day in 2 divided doses (in the morning).

Side effects of Indapamide MB

On the part of the gastrointestinal tract: nausea / anorexia, dry mouth, gastralgia, vomiting, diarrhea, constipation.
From the nervous system: asthenia, nervousness, headache, dizziness, drowsiness, vertigo, insomnia, depression; rarely - increased fatigue, general weakness, malaise, muscle spasm, tension, irritability, anxiety.
From the senses: conjunctivitis, blurred vision.
On the part of the respiratory system: cough, pharyngitis, sinusitis, rarely - rhinitis.
Since the cardiovascular system: orthostatic hypotension, changes in the electrocardiogram (hypokalemia), arrhythmia, palpitations.
On the part of the urinary system: frequent infections, nocturia, polyuria.
Allergic reactions: rash, urticaria, pruritus, hemorrhagic vasculitis.
Laboratory indicators: hyperuricemia, hyperglycemia, hypokalemia, hypochloremia, hyponatremia, hypercalcemia, increased urea nitrogen in the blood plasma, hypercreatininemia, glucosuria.
Others: flu-like syndrome, chest pain, back pain, infections, reduced potency, decreased libido, rhinorrhea, sweating, weight loss, tingling of limbs, pancreatitis, exacerbation of systemic lupus erythematosus.

special instructions

In patients taking cardiac glycosides, laxatives, on the background of hyper aldosteronism, as well as in elderly people, regular monitoring of the content of K + ions and creatinine is shown.
When receiving Indapamide MB, the concentration of K +, Na +, Mg 2+ ions in plasma should be systematically monitored (electrolyte abnormalities may develop), pH, glucose, uric acid and residual nitrogen concentrations.
The most careful control is shown in patients with cirrhosis of the liver (especially with edema or ascites - the risk of developing metabolic alkalosis, enhancing manifestations of hepatic encephalopathy), coronary heart disease, heart failure, as well as in elderly patients.
Patients with an increased QT interval on an electrocardiogram (congenital or developed on the background of any pathological process) also belong to an increased risk group.
The first measurement of K + concentration in the blood should be carried out during the first week of treatment.
Hypercalcemia with Indapamide MB may be due to previously undiagnosed hyperparathyroidism.
In patients with diabetes, it is extremely important to control the level of glucose in the blood, especially in the presence of hypokalemia.
Significant dehydration can lead to the development of acute renal failure (reduced glomerular filtration). Patients need to compensate for the loss of water and at the beginning of treatment carefully monitor kidney function.
Indapamide MB can give a positive result during doping control.
Patients with arterial hypertension and hyponatremia (due to diuretic administration) need 3 days before the angiotensin-converting enzyme inhibitors are taken to stop taking diuretics (if necessary, diuretics can be taken some time later), or they are prescribed initial low doses of angiotensin-converting enzyme inhibitors.
Sulfonamide derivatives can aggravate the course of systemic lupus erythematosus (must be borne in mind when prescribing Indapamide MB).
Use in pediatrics: efficacy and safety in children has not been established.

Interaction

Saluretics, cardiac glycosides, gluco-and mineralocorticoids, tetracosactide, amphotericin B (w / w), laxatives increase the risk of hypokalemia.
When taken simultaneously with cardiac glycosides increases the likelihood of digitalis intoxication; with drugs Ca 2+ - hypercalcemia; with metformin - possible aggravation of lactic acidosis. Increases the concentration of Li + in the blood plasma (decrease in urine excretion), lithium has a nephrotoxic effect.
Astemizol, erythromycin IV, pentamidine, sultoprid, terfenadine, vincamine, class Ia antiarrhythmic drugs (quinidine, disopyramide) and class III (amiodarone, bretilium, sotalol) can lead to the development of arrhythmias of the "torsades de pointes" type.
Non-steroidal anti-inflammatory drugs, glucocorticosteroid drugs, tetrakozaktid, sympathomimetics reduce the hypotensive effect, baclofen - increases.
The combination with potassium-sparing diuretics may be effective in a certain category of patients, however, this does not completely exclude the possibility of the development of hypo-or hyperkalemia, especially in patients with diabetes mellitus and renal failure.
Angiotensin-converting enzyme inhibitors increase the risk of arterial hypotension and / or acute renal failure (especially with existing stenosis of the renal artery).
Increases the risk of developing renal dysfunction when using iodine-containing contrast agents in high doses (dehydration of the body).
Before using iodine-containing contrast agents, patients need to restore fluid loss.
Imipramine (tricyclic) antidepressants and antipsychotics increase the hypotensive effect and increase the risk of orthostatic hypotension. Cyclosporine increases the risk of hypercreatininemia.
Reduces the effect of indirect anticoagulants (coumarin or indanedione derivatives) due to increased concentration of coagulation factors as a result of a decrease in circulating blood volume and an increase in their production by the liver (dose adjustment may be required).
Strengthens the blockade of neuromuscular transmission, which develops under the influence of non-depolarizing muscle relaxants.

Overdose

Symptoms: nausea, vomiting, weakness, dysfunction of the gastrointestinal tract, water and electrolyte disturbances, in some cases - an excessive decrease in blood pressure, respiratory depression. Patients with cirrhosis may develop hepatic coma.
Treatment: gastric lavage, correction of water and electrolyte balance, symptomatic therapy. There is no specific antidote.
Shelf life - 3 years.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 ° C.

Terms of sell

You can buy Indapamide MB without a prescription.