Inspra tabs 25mg #30

Instruction for Inspra

You can buy Inspra online

Composition

Eplerenone, lactose monohydrate, croscarmellose sodium, microcrystalline cellulose, sodium lauryl sulfate, hypromellose, magnesium stearate, talc, opadry yellow.

Form of issue

Yellow diamond tablets of 25 and 50 mg in a blister in a cardboard package, No. 30.

pharmachologic effect

Diuretic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The active substance of the drug prevents the binding of androgenic and progesterone receptors with aldosterone, which is involved in the regulation of blood pressure and the development of diseases of the cardiovascular system. The addition of eplerenone to CHF therapy leads to a predicted increase in aldosterone levels. Administration of the drug to patients with acute myocardial infarction significantly reduces the risk of mortality in this group of diseases. The hypotensive effect was manifested on average after two weeks and reached a maximum after a month of constant admission, and its expression persisted for 8-24 weeks.

Pharmacokinetics

The absorption of eplerenone and its distribution in the body occurs quickly enough (Cmax is achieved in 2 hours). Bioavailability is 69%. Absorption is not affected by absorption. Eplerenone binds to blood plasma proteins by 50%, does not bind to erythrocytes. It is excreted in urine (about 67%) and feces (about 32%). Half-life is about 3-5 hours.

Indications for use

In the therapy of myocardial infarction in order to reduce sudden cardiac and total mortality; after myocardial infarction in the presence of left ventricular failure.
As part of the standard treatment of CHF (chronic heart failure).

Contraindications

    Hepatic / renal failure in severe form;
    Clinically expressed hyperkalemia;
    Individual hypersensitivity to the drug;
    Simultaneous reception of potassium preparations;
    Insufficiency of lactase, galactose intolerance;
    Age to 18 years.

Side effects

Dizziness, headache, fainting; hyperkalemia, eosinophilia, insomnia, decreased blood pressure, atrial fibrillation, left ventricular failure, myocardial infarction, cough, pharyngitis, diarrhea, nausea, constipation, cholecystitis, vomiting, flatulence, excessive sweating, itching, local allergic reactions, asthenia, malaise.

Inspra, instructions for use

With myocardial infarction, chronic heart failure, the drug starts with a dose of 25 mg and increases the dose to 50 mg during the month under the control of the potassium concentration in the blood. Take the drug once a day.
Older patients, as well as patients with mild to moderate liver and kidney function, do not need to adjust the starting dosage. Reception of the drug with food is not connected.

Overdose

Cases of an eplerenone overdose have not been described. Possible symptoms of an overdose may be hyperkalemia and a decrease in blood pressure.

Interaction

Eplerenone is not recommended to be taken concomitantly with potassium preparations, as they increase the effect of antihypertensive drugs. It is necessary to avoid simultaneous reception of eplerenone and lithium, as the risk of lithium intoxication increases. You can not simultaneously appoint eplerenone with tacrolimus and cyclosporine, as the risk of hyperkalemia and renal dysfunction increases.
Neuroleptics, tricyclic antidepressants, baclofen and amifostine with simultaneous use with eplerenone enhance the antihypertensive effect. Simultaneous use of eplerenone with glucocorticoids leads to a delay in fluid and sodium in the body. The simultaneous administration of eplerenone with trimethoprim increases the risk of hyperkalemia.

Terms of sale

You don't need a prescription to buy Inspra online.

Storage conditions

At a temperature of no higher than 25 ° C.
Shelf life - 2 years.

Reviews about Inspra

According to doctors' reviews, the drug Inspra is quite effective. Observation of patients after a heart attack and CHF shows a significant decrease in pre- and post-loading on the heart, slows the progression and development of left ventricular hypertrophy of the heart, lowers blood pressure, improves diastolic function of the ventricle, reduces congestion and swelling of soft tissues.