Moxonidine-sz tabs 400mcg #60

Moxonidine-sz user manual

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Composition

One tablet contains 200 μg of the active ingredient Moxonidine.
As auxiliary substances, microcrystalline cellulose, klocel, A-380 aerosil, castor oil, polyvinylpyrrolidone, tween-80, magnesium stearate are used.

Form of issue

The drug is produced in coated tablets, in a honeycomb package of 14 pieces, in a cardboard bundle there can be 14, 28 pieces - 1 or 2 blisters.

pharmachologic effect

Antihypertensive effect.

Pharmacodynamics and pharmacokinetics

The active substance Moxonidine is a selective imidazoline receptor agonist and is responsible for tonic and reflex control of the sympathetic nervous system localized in the medulla oblongata in the ventral-lateral region. The drug is able to reduce systolic and diastolic blood pressure with a one-time admission and long-term therapy by reducing the pressor influence of the sympathetic system on peripheral vascular resistance and peripheral vessels, without significant changes in cardiac output and heart rate.
Absorption occurs by 90% regardless of meals. Bioavailability is 88%, and 7% binds to plasma proteins. The substance is able to pass through the blood-brain barrier, penetrate into the milk, long-term administration does not lead to accumulation. The maximum concentration in the plasma is achieved after 0.5-3 hours and is 1-3 picograms per ml, taking into account that the volume of distribution is in the range of 1.4-3 liters per kg. Half-life is several hours. 90% is excreted by the kidneys, 70% in unchanged form, the rest - in the form of metabolites.

Indications for use

The drug is prescribed for an arterial hypertension in an anamnesis.

Contraindications

    hypersensitivity to the components that make up the drug;
    syndrome of weakness of the sinus node;
    disturbances of the upper atrial and atrioventricular conduction of 2nd-3rd degree;
    pronounced bradycardia at a heart rate less than 50 beats per 1 minute;
    severe arrhythmias;
    heart failure;
    the presence in the anamnesis of information about the experienced angioedurotic edema;
    glaucoma;
    severe violations of the normal functioning of the liver and kidneys;
    various violations of peripheral blood circulation, including Parkinson's disease, Raynaud's disease, obliterating atherosclerosis, syndrome of intermittent claudication;
    epilepsy;
    depression;
    unstable angina;
    intolerance to galactose, or a deficiency of lactose, or malabsorption of glucose and galactose;
    pregnancy or lactation period;
    age category up to 18 years.

Side effects

Moxonidine may cause the following adverse reactions:
    vomiting, indigestion, dry mouth, diarrhea, nausea;
    skin rash, itching;
    increased fatigue;
    asthenic condition;
    migraine;
    dizziness (vertigo);
    various sleep disorders or drowsiness;
    nervousness;
    orthostatic hypotension or bradycardia;
    peripheral edema.

Moxonidine, instructions for use (Method and dosage)

Is taken orally, starting at a dose of 200 mcg once a day. The maximum acceptable single dose should not be more than 400 mcg, whereas the allowable daily dose - up to 600 mcg in two doses. Instructions for use Moxonidine indicates the need to adjust the daily dose on an individual basis on the basis of data on the tolerability of therapy.

Overdose

It is accompanied by headaches and dizziness, sedation, vomiting, spasms in the stomach, excessive decrease in blood pressure with general weakness and dry mouth. Treatment prescribed symptomatic in the form of gastric lavage, the introduction of activated charcoal and laxative.
Reduction of blood pressure requires the restoration of blood volume by the introduction of saline, bradycardia is stopped by Atropine.
Specific antidote Idazoxan is a well-known antagonist of imidazolines.

Interaction

The combined use of Moxonidine with the following agents and preparations results in:
    With antihypertensive drugs - to the additive effect.
    With tricyclic antidepressants, tranquilizers, ethanol, sedatives and hypnotics - it is possible to enhance the action of Moxonidine.
    Lorazepam - improvement of weakened cognitive functions.
    To increase the sedative effect of benzodiazepine derivatives.

Terms of sale

You don't need a prescription to buy Moxonidine online.

Storage conditions

In a dry dark place, not accessible to children, at a temperature of not more than 25 ° Celsius.
Shelf life - three years.

special instructions

Treatment requires regular monitoring of blood pressure, heart rate and ECG, it is desirable to exclude the use of alcohol, work with mechanisms and driving, as well as other activities that require increased attention or high reaction rates. It is necessary to stop the course gradually.
If it is necessary to cancel simultaneous β-blockers and Moxonidine, then β-blockers should be abolished first, then Moxonidine can be canceled in a few days.

Reviews of Moxonidine

Reviews about the drug are positive, they confirm its effectiveness in reducing blood pressure, both with rapid docking, and with long-term treatment.