Tenzotran tabs 0.4mg #28

Tenzotran user manual

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Composition

In 1 tablet of moxonidine 200, 300, 400 mcg. Lactose monohydrate, crospovidone, povidone, opadrai, magnesium stearate, dye as auxiliary substances.

Form of issue

Tablets in the film coat 200, 300, 400 μg No. 42, 28 and 14.

pharmachologic effect

Antihypertensive.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Selectively stimulates imidazoline I1 receptors of the medulla oblongata, which leads to a decrease in the tone of sympathetic innervation and, as a result, a decrease in OPSS, heart rate and heart rate (to a lesser extent). At the same time, the volume of cardiac output practically does not change. Effectively lowers blood pressure, reduces the level of aldosterone and norepinephrine, angiotensin II and renin. Prevents development of myocardial hypertrophy. Has a hypoglycemic effect, which is associated with the excitation of imidazoline receptors of the pancreas.
The cardioprotective action was established hypolipidemic and experimentally proved. Stimulates the production of growth hormone. The hypotensive effect lasts 12 hours. Addiction and withdrawal symptoms are not noted.

Pharmacokinetics

Quickly absorbed in the digestive tract. The maximum concentration in the blood is determined after 1 h. It is converted into metabolites with low activity. It is excreted by the kidneys. T1 / 2 2-3 hours With renal failure cumulation is not noted.

Indications for use

    symptomatic arterial hypertension;
    Hypertension in combination with metabolic syndrome (+ type II diabetes + obesity);
    hypertonic disease;
    relief of hypertensive crises.

Contraindications

    heart failure III and IV FC;
    hypersensitivity;
    bradycardia;
    AV blockade II-III degree;
    obliterating endarteritis;
    unstable angina;
    syndrome of weakness of the sinus node;
    Raynaud's disease;
    Parkinsonism, epilepsy;
    glaucoma;
    depressive conditions;
    pregnancy, lactation;
    renal and hepatic impairment;
    age to 16 years.

Side effects

The most common adverse reactions are:
    dry mouth;
    fatigue;
    headache;
    nausea;
    drowsiness.
Rarely encountered adverse reactions:
    orthostatic hypotension;
    paresthesia, Raynaud's syndrome;
    insomnia, asthenia;
    anorexia, hepatitis, cholestasis;
    cutaneous manifestations;
    retention of urine;
    impotence, decreased libido;
    dryness of the conjunctiva of the eyes;
    fluid retention;
    fainting.

Tenzotran, instructions for use (Method and dosage)

The drug is taken internally. Treatment begins with a dose of 200 mcg in one session, in the morning. If the effect is insufficient, after 3 weeks the dose is increased to 400 mcg in one dose in the morning, or divided into two doses (morning-evening). The maximum SD is 600 μg divided into 2 doses.
Elderly people with preserved kidney function do not adjust the dose. With renal failure, a single dose of 200 μg, and a daily dose of 400 μg.
The use of Tenzotran under the tongue is practiced with hypertensive crises. For this, the 0.4 mg tablet must be ground, the powder poured out under the tongue and after 30 -50 minutes the blood pressure gradually decreases by 15% -20%.

Overdose

It is manifested by headache, drowsiness, dizziness, excessive sedation, pronounced decrease in blood pressure, bradycardia, dryness of the oral mucosa, vomiting.
There is no specific antidote. The stomach is washed, sorbents and laxatives are taken. It is recommended the administration of dopamine with a sharp decrease in blood pressure and atropine with bradycardia.

Interaction

Moxonidine is prescribed with calcium channel blockers and thiazide diuretics - their combined use increases the hypotensive effect.
Strengthens the effect of tricyclic antidepressants, sedatives and hypnotics, tranquilizers. Potentiates the effect of ethanol. Tricyclic antidepressants, in turn, reduce the effect of central antihypertensive agents.
Improves cognitive function in persons taking lorazepam.
Since moxonidine is excreted by the kidneys, it is possible for it to interact with drugs released in the same way.

Terms of sale

You can buy Tenzotran without a prescription.

Storage conditions

Temperature up to 25 ° С.
Shelf life - tablets 300 and 400 mkg - 3 years, 200 mcg -2 years.

Reviews of Tenzotran

Reviews in general are positive. Some people with mild hypertension took this drug as monotherapy, others - in combination with β-adrenoblockers and diuretics. Many reviews from patients suffering from hypertension and diabetes, who noted that with the use of this drug, diabetes mellitus was compensated. Some patients who had previously taken the original moxonidine Physiotens (Abbott) note that it is stronger and faster than blood pressure lowering than the generic Tenzotran. Those taking this drug rarely encountered side effects. Most often - a headache and insignificant drowsiness.