Nifecard XL tabs 30mg #30

Tablets Nifecard XL user manual

Reed more and buy Nifecard XL pills on this page

Composition

The film-coated tablets include an active component of nifedipine.
Additional components: sodium lauryl sulfate, povidone, hypromellose, ludipress, magnesium hydrosilicate and stearate.
The tablet shell consists of hypromellose phthalate, triethyl citrate, titanium dioxide, hypromellose, macrogol, magnesium hydrosilicate, iron oxide, yellow oxide.

Form of issue

Nifecard XL is produced in the form of controlled release capsules coated with a film membrane, containing 30 and 60 mg of the active substance.
Tablets are packaged in 10 pieces in blisters, 2 or 3 blisters in a pack.

pharmachologic effect

The drug is characterized by hypotensive and antianginal action.

Pharmacodynamics and pharmacokinetics

Nifedipine XL is a selective blocker of "slow" calcium channels, derivatives of 1,4-dihydropyridine. The drug is characterized by an antianginal and hypotensive effect. This reduces the flow of extracellular calcium to cardiomyocytes and smooth muscle cells of peripheral and coronary arteries. High doses can inhibit the release of calcium ions from the intracellular depot. Also, the number of functioning channels is reduced, without affecting the time period of their activation, recovery and inactivation.
In addition, there was a separation of the processes of contraction and excitation in the myocardium, which mediate tropomyosin and troponin, in smooth vascular muscles mediated by calmodulin. Therapeutic doses of the drug allow normalizing the transmembrane current of calcium ions, damaged due to various pathological conditions, for example, arterial hypertension. In this case, there is no effect on the tone of the veins. The coronary blood flow increases, the blood supply in the ischemic zones of the myocardium improves, the development of the phenomenon of stealing is prevented, the functioning of collaterals is activated, and so on.
The drug is characterized by a delayed release of the main component, which ensures its gradual controlled increase in plasma concentrations, which occurs approximately 6 hours later and is maintained for 24 hours. Within the body, the substance is rapidly and fully absorbed, binding to blood plasma proteins. Metabolism occurs in the liver, forming inactive metabolites. Excretion from the body occurs mainly with the kidneys and a minor part - with bile.
The active substance penetrates the placental barrier, BBB and is excreted in the breast milk.
No cumulative effect was observed. Prolonged reception can cause the development of tolerance to Nifecard.

Indications for use

Nifecard XL is prescribed for treatment:
    arterial hypertension;
    IHD: stable angina pectoris, vasospastic angina.

Contraindications for use

The drug is not recommended for:
    hypersensitivity to nifedipine and other components;
    severe arterial hypotension and stenosis of the aortic valve;
    chronic heart failure, cardiogenic shock, acute myocardial infarction;
    lactation, I trimester of pregnancy.
Care must be taken when treating patients with severe stenosis of the mitral valve or aortic aorta, hypertrophic obstructive cardiomyopathy, tachycardia, unstable angina, sinus node weakness syndrome, hypertension, myocardial infarction and left ventricular failure and so on.

Side effects

In the treatment of Nifecard, side effects can occur that affect various organs and systems, for example, cardiovascular, nervous, digestive, urinary. There may be abnormalities in the work of the organs of hematopoiesis, musculoskeletal system and so on.
Therefore, patients can be disturbed by such negative symptoms as: asymptomatic pressure decrease, hyperemia, tachycardia, arrhythmia, headache, dizziness, weakness, fatigue, dry mouth, indigestion, anemia, thrombocytopenia, arthritis and the like.
Also, the development of allergic reactions and general symptoms of drug intolerance is not ruled out.

Instructions for use Nifecard XL (Method and dosage)

Tablets should be taken whole by drinking with water. The dosage regimen for each specific case and type of disease is established individually.
As indicated by the instructions for Nifecard XL 60 mg or 30 mg, take the drug once a day. Usually begin treatment with a minimum daily dosage of 30 mg. If necessary, correction is carried out with observance of an interval of 7-14 days.
The maximum allowable daily dosing is 90 mg.

Overdose

In cases of overdose, it is possible to develop such symptoms as: peripheral vasodilation and severe arterial hypotension accompanied by headache, flushing of the facial skin, suppression of sinus node functioning, bradycardia, tachycardia, bradyarrhythmia.
Severe poisoning can lead to loss of consciousness, coma.
In this case, standard procedures are performed to remove the basic substance from the body, for example, the stomach is washed, Activated charcoal is prescribed. Also, they restore stable parameters of hemodynamics, control cardiac activity, excretory system and lung function. Hemodialysis will be ineffective, and as an antidote use calcium preparations.

Interaction

Combination therapy with other antihypertensive drugs, diuretics, nitrates, cimetidine, beta-blockers, ranitidine, tricyclic antidepressants can lead to a decrease in pressure.
The combination with quinidine reduces its concentration in the blood plasma. With simultaneous treatment with Digoxin and Theophyllin, on the contrary, their plasma concentration increases.
Inducers of microsomal liver enzymes, for example, Rifampicin, can reduce the concentration of nifedipine. Nitrates can strengthen tachycardia, and sympathomimetics, calcium preparations, estrogens - reduce the hypotensive effect.
It was found that nifedipine displaces other drugs with a high degree of binding from the link with proteins: anticoagulants, derivatives of Indandion and Kumarin, anticonvulsants, quinine, sulfinpyrazone, salicylates, which leads to an increase in their concentration in the blood plasma.
When a combination of nifedipine and Vincristine is inhibited its removal from the body, it is possible to increase side effects.
It is possible to increase the toxic effects of lithium preparations, which is expressed by: nausea, vomiting, diarrhea, ataxia, tremor, tinnitus.
Simultaneous appointment of cephalosporins, for example, Cefixime, significantly increases its bioavailability.
Grapefruit juice can inhibit the metabolism of nifedipine, for this reason, during the period of treatment it is not recommended to use it.

Terms of sale

You can buy Nifecard XL without a prescription.

Storage conditions

The drug should be stored in a dry, cool place, inaccessible to children.
Shelf life - 3 years.

Alcohol

During the treatment of ethanol is not recommended, as this can increase the development of side effects.

Reviews of Nifecard XL

In most cases, reviews about Nifecard occur in various medical forums where you can consult about the purpose and effects of medications. In this case, the opinion about this drug, both in patients and specialists, is quite positive.
Specialists report that Nifecard has a form with slow release of the main component, which determines its effectiveness. For many patients with hypertension, it helps control blood pressure and improve heart function.
Often there are patient questions related to the duration of treatment, as Nymphecard usually takes long enough.
Experts answer that if the therapeutic scheme is chosen correctly, then the drug does take an indefinitely long time, almost all life. However, periodically it is necessary to monitor the functions of the body.
Thus, the most important thing in treatment is a well-chosen scheme. Therefore, you can take Nifecard strictly according to the doctor's prescription, which will ensure rapid and effective therapy.