Niperten tabs 5mg #100

Niperten user manual

Reed more and buy Niperten on this page

Composition

Depending on the form of release in the chemical composition of a single Nipperen tablets (INN Bisoprolol) may contain 2.5 mg. 5 mg. or 10 mg. active bisoprolol fumarate drug.
Povidone, magnesium stearate, carboxymethyl starch, as well as MCC and colloidal silicon dioxide (anhydrous) are part of the Nipperen as adjuvants.
Titanium dioxide, macrogol and talc are contained in the film membrane of Niperten tablets.

Form of issue

The drug is released in the form of biconvex tablets, nominal volume of 2.5 mg., 5 mg. and 10 mg., coated with a coat of light white color, on top of which, on the one hand, there is a risk (on the one hand).

pharmachologic effect

Niperten has antihypertensive, beta-adrenoblokiruyuschim, antianginal, as well as antiarrhythmic pharmacological action.

Pharmacodynamics and pharmacokinetics

In its essence, Niperten is a beta1-adrenoblocker belonging to selective compounds, it does not possess membrane-stabilizing properties without its own sympathomimetic activity. This medicine helps to reduce the level of renin in the blood, and also reduces the need for myocardium in oxygen.
The drug has a pronounced antiarrhythmic, antihypertensive and anti-anginal effect on the body. Due to its distinctive properties, Niperten can affect the intensity of the ionic calcium current at the intracellular level, and also blocks beta 1-adrenergic receptors formed in small doses in the heart, thereby slowing down the formation of cAMP (cyclic adenosine monophosphate) from ATP.
The antiarrhythmic effect of NIPERTEN is due to the ability of the drug to increase the amount of cyclic adenosine monophosphate, as well as to eliminate such arrhythmogenic factors as tachycardia, hypertension, and increased activity of the nervous system. Under the influence of Niperten, the demand for myocardium in oxygen becomes less as a result of reduced contractility of the main cardiac muscle, due to which the antianginal effect of the drug is achieved.
The drug compound achieves an antihypertensive effect due to a reduction in blood volume (per 1 minute), restoration of sensitivity (the result of influence on the central nervous system and lowering blood pressure), and also by stimulation of peripheral blood vessels. Under the influence of active α-adrenoreceptors, as well as with a decrease in stimulation of β2-adrenoreceptors in the first 24 hours after taking the drug, OPSS (total peripheral vascular resistance) increases.
However, after 3 days, the indicators return to normal, and with prolonged therapeutic treatment - go down. It is noted that, in comparison with similar drugs, Niperten has a less pronounced effect on carbohydrate metabolism, as well as such organs containing β2-adrenergic receptors in their tissues, such as: bronchi, pancreas, peripheral arteries, uterus.
The drug compound is absorbed by 80-90%. About half the dose of the drug is metabolized with the involvement of the liver for 12 hours. In the future, the kidneys remove about 98% of the active compound from the body.

Indications for use

From what tablets? Niperten is shown when:
    hypertension;
    ischemic heart disease;
    heart failure;
    prevention of angina attacks.

Contraindications

It is not recommended to use the drug when:
    collapse;
    hypersensitivity to beta-blockers and other components of the drug;
    pulmonary edema;
    sinoatrial blockade;
    bradycardia;
    cardiomegaly;
    weakness of the sinus node;
    angina of Prinzmetal;
    bronchial asthma;
    violation of peripheral circulation;
    pheochromocytoma;
    AV blockade II-III degree.
Niperten is contraindicated in patients who have not reached the age of 18 years. In addition, especially to the dosage and regimen of the drug should be approached by patients with diabetes, as well as kidney failure, thyrotoxicosis, psoriasis, myasthenia, and elderly people.

Side effects

The use of the drug causes such side effects as:
    weakness, increased fatigue and dizziness;
    sleep disorders;
    headaches and memory impairment;
    hallucinations and depressive condition;
    myasthenia gravis;
    convulsions;
    decreased vision;
    conjunctivitis;
    arrhythmia;
    Raynaud's syndrome;
    bradycardia;
    chest pain;
    vomiting and nausea;
    constipation or diarrhea;
    change in taste;
    difficulty breathing;
    hyperglycemia in diabetes;
    hypoglycemia;
    hypothyroid condition;
    rashes on the skin;
    alopecia;
    leukopenia;
    thrombocytopenia;
    arthralgia;
    decreased potency;
    backache.

Niperten, instructions for use (Method and dosage)

In accordance with the instructions for the use of Niperten, the drug is taken once a day on an empty stomach before breakfast. The dosage of the drug depends on the disease and the condition of the patient. The recommended dosage of the drug is 5 mg. can be gradually increased to a maximum of 20 mg. per day.

Overdose

When an overdose of the drug, the following symptoms appear: bradycardia, arrhythmia, difficulty breathing, cyanosis, dizziness, convulsions, fainting. If the above symptoms occur, the patient should immediately consult a doctor.

Interaction

To avoid complications or side effects in the treatment of Niperten should be avoided:
    allergens that are used in immunotherapy;
    iodine-containing radiopaque agents for intravenous administration of drugs;
    phenytoin, means for inhalation anesthesia;
    antihypertensive drugs;
    antidepressants, sedatives and hypnotics;
    unhydrogenated ergot alkaloids;
    ergotamine;
    antiarrhythmic drugs.
The active drug changes the effectiveness of insulin, and also increases the concentration of xanthines and the clearance of lidocaine in the blood.

Terms of sale

To buy Niperten you don't need a prescription.

Storage conditions

Niperten refers to drugs from list B and can be stored at a temperature not exceeding 30 ° C.
Shelf life - 2 years.

special instructions

The condition of patients undergoing Niperten treatment should be constantly monitored by medical personnel. For elderly patients, renal function research is recommended at least once every 5 months. Physicians are advised to teach patients how to calculate the heart rate (heart rate), so that they can, if necessary, control their own condition.
Before starting direct treatment for patients with bronchopulmonary anamnesis, a comprehensive airway examination is recommended. On the background of treatment, the discharge of tear fluid can decrease, this should be taken into account for patients using contact lenses.

Children

The drug is not recommended for patients under the age of 18 years.

During pregnancy (and lactation)

The drug is not desirable to use during pregnancy without acute medical necessity. Breastfeeding during treatment Niperten should be discontinued.

Reviews of Niperten

Although people for the most part leave positive reviews about Niperten, many note as a negative factor a large number of side effects of the drug.