Panangin tabs #100

Instruction for Panangin tabs

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Composition of Panangin

Composition of tablets

Active substances: magnesium asparaginate (140 mg) and potassium asparaginate (158 mg).
Additional substances: silicon dioxide, corn and potato starch, talc, povidone, magnesium stearate. The shell consists of talc, macrogol 6000, titanium dioxide, methacrylic acid copolymer.
Concentrate for solution (Panangin IV)
Contains magnesium asparaginate (40 mg) and potassium asparaginate (45.2 mg), as well as water for injection.

Form of issue

Produced in tablet form, and in the form of a concentrate solution.

pharmachologic effect

What is the medicine for? It is a source of potassium, magnesium. The drug helps to restore electrolyte balance, regulates metabolic, metabolic reactions and processes, has a pronounced antiarrhythmic effect. Potassium takes an active part in the synaptic transmission, in the conduct of a nerve impulse along the fibers, in the implementation of muscle contractions, supports the normal functioning of the heart. With disturbed potassium metabolism, the excitability of muscle tissue and nerves changes. Thanks to the active ion transport, a high potassium gradient is maintained through the plasma membrane. Small dosages of potassium promote the expansion of coronary arteries, and in large doses the trace element narrows their lumen. Potassium has a moderate diuretic effect, negative batmotropnoe and chronovrnoe influence. Magnesium is a cofactor of three hundred serum reactions. Magnesium is an indispensable element in the flow of processes and reactions that ensure the supply, as well as the expenditure of energy. Magnesium enters the pentose-phosphate structure of DNA, takes part in the process of cell division and growth, the structure of heredity, the synthesis of RNA; is a natural BCCI, prevents the release of free fatty acids, catecholamines under stress, promotes the penetration of potassium ions into the cell. The drug has a stimulating effect on the intercellular synthesis of phosphates.
Mn: potassium and magnesium asparaginate.
Pharmacological group: potassium and magnesium preparation.

Pharmacodynamics and pharmacokinetics

The active substances play an important role in the formation of connections between macromolecules, as well as intracellular structures and the mechanism of muscle contraction, myocardial metabolism.
According to the annotation the preparation is well absorbed. It is excreted through the kidneys.

Indications for the use of Panangin

Panangin tablets - what are they from?

Indications for the use of Panangin are as follows. The drug is prescribed for hypomagnesemia, hypokalemia, with the use of laxatives and diuretics, glucocorticosteroids, with diarrhea, persistent vomiting, saluretic treatment, myocardial infarction, heart failure, digitalis intoxication, ventricular extrasystole, atrial extrasystole, supraventricular tachycardia, paroxysmal tachycardia.
Example of a recipe in Latin: Rp .: Dragee "Panangin" N. 20

Contraindications to Panangin

The drug is not used for intolerance to fructose, sorbitol, disrupted amino acid metabolism, chronic renal system pathology, hemolysis, exsicosis, dehydration, arterial hypotension, myasthenia gravis, atrioventricular blockade, hypermagnesia, hyperkalemia, metabolic acidosis, Addison's disease. Panangin during pregnancy is used with caution.

Side effects

Side effects include: ulceration of the mucosa of the digestive tract, epigastric pain, diarrhea, bleeding from the digestive system, a drop in blood pressure, a bradycardia, a paradoxical reaction in the form of an increase in the number of extrasystoles, dry mouth, nausea, flatulence, hyporeflexia, itching , dyspnoea, thrombosis, phlebitis, paresthesia, dizziness, increased sweating, asthenia, myasthenia gravis. With a rapid intravenous infusion, hypermagnesia, hyperkalemia, is noted.
Instructions for the use of Panangin (Method and dosage)

Panangin tablets, instructions for use

How to drink a medicine? The drug is taken orally three times a day for 2 tablets. Supportive and preventive therapy: three times a day for 1 dragee, course for 3-4 weeks. In some situations, a repeat course of therapy is required.

How to take Panangin for prophylaxis?

If you ask yourself the benefit and harm of Panangin, you should realize that this is a medicine that has its side effects, so do not use it for prevention. First, you thus accustom the body to a high content of magnesium and potassium, and secondly - can provoke an excess of these substances, which in turn can cause a lot of negative reactions.

Overdose

It manifests with hypotonic muscle, hyperkalemia, slowing of atrioventricular conduction, cardiac arrest, arrhythmia, paresthesia of the extremities, changes in the electrocardiogram. Requires an urgent intravenous infusion of a solution of dextrose, sodium chloride. If necessary, it is justified to carry out peritoneal dialysis, hemodialysis.

Interaction

Panagin is able to intensify the negative batmotropic, dromotropic effects of antiarrhythmic drugs. The drug eliminates hypokalemia, which develops against the background of long-term use of diuretics, glucocorticosteroids, ISS. NSAIDs, ACE inhibitors, heparin, potassium-sparing diuretics, cyclosporine, beta-adrenoblockers increase the risk of hyperkalemia. With the use of general anesthetics, the inhibitory effect of panangin on the nervous system is enhanced. Succinyl chloride, decamethonium, atracuronium, suxamethonium increase neuromuscular blockade. The use of enveloping and astringent medicines reduces the absorption of potassium and magnesium in the digestive tract. In combination with insulin, dextrose in the polarizing mixture normalizes the heart rhythm with an overdose of cardiac glycosides, with ectopic arrhythmias, myocardial infarction. Panangin improves the tolerability of cardiac glycosides, is pharmaceutically compatible with their solutions.

Terms of sale

Does not require a prescription.

Storage conditions

In a place inaccessible to children at a temperature of 15-30 degrees Celsius.

Shelf life

Not more than 5 years.

Compatibility with alcohol

The drug is poorly compatible with alcohol, if only because the drug is usually used for problems with the heart and the vascular system, and alcohol in these cases should be excluded. However, that's not all. With the simultaneous use of these substances can occur spasm of blood vessels.

Reviews about Panangin

Reviews about Panangin on the forums are mostly positive. Buyers note the drug as really effective, the drug facilitates the work of the heart, removes cramps, really helps. It is noted as a good pill for the heart.
Reviews about Panangin during pregnancy are as follows: the medication is often prescribed by doctors and is quite effective, despite the fact that it is recommended to use the remedy with caution during this period.