Pentoxifylline tabs 100mg #60

Pentoxifylline user manual

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Composition

Active substance Pentoxifylline.
Tablets contain 100 and 400 mg of this substance.
Additional elements: titanium dioxide, lactose, potato starch, propylene glycol, magnesium stearate, hypromellose, povidone, methacrylate copolymer dispersion, talc, carmosein.
The solution concentrate and Pentoxifylline IV solution and in / a administration contain 20 mg of substance per ml. A solution for infusion may also contain 2 mg per ml.

Form of issue

Tablet form, as well as solution concentrates and solutions for intravenous and / or injection in ampoules.

pharmachologic effect

Antispasmodic. It improves microcirculation, has an angioprotective, anti-aggregation effect. Expands blood vessels.

Pharmacodynamics and pharmacokinetics

The drug has a positive effect on the flow properties of blood, moderately improves microcirculation, saturates the energy potential and increases the concentration of cAMP in platelets, inhibits phosphodiesterase, causes vasodilation, does not affect heart rate. The drug increases the lumen of the coronary arteries, which significantly increases the amount of oxygen supplied to the myocardium (antianginal action); expands the pulmonary vessels, which makes it possible to improve the oxygenation of the blood. The drug increases the tone of the diaphragm, intercostal muscles and respiratory muscles. With intravenous administration, collateral circulation increases, increases the volume of blood flowing through the unit of section. Pentoxifylline positively affects the bioelectrical activity and activity of the nervous system, increases the level of ATP in the brain. The use of the drug increases the elasticity of erythrocytes (due to the effect on the pathological deformability of red blood cells of blood), causes disaggregation of platelets, reduces the viscosity of the blood. In areas with impaired blood supply, the drug significantly improves microcirculation. Pentoxifylline eliminates pain and cramps in the calf muscles, allows you to increase the walking distance with intermittent claudication (occlusive damage to peripherally located arteries).
Quickly absorbed. Mostly excreted by urine metabolites, less - with feces. The maximum concentration of the substance is reached in an hour after application.

Indications for use Pentoxifylline

From what tablets and a solution? The agent is prescribed for violations in peripheral blood supply, tissue trophism, Raynaud's disease, obliterating endarteritis, post-thrombotic syndrome, with frostbites, gangrene, trophic ulcers of the lower leg, varicose veins, cerebral atherosclerosis, viral neuroinfection, discirculatory encephalopathy. Also indications for the use of Pentoxifylline are: transferred myocardial infarction, coronary heart disease, bronchial asthma, acute disorders in the blood supply of the retina, choroid of the eye, otosclerosis, impotence of vascular genesis.

Contraindications

Pentoxifylline is not prescribed for intolerance to xanthine derivatives, porphyria, acute myocardial infarction, hemorrhagic stroke, massive blood loss, pregnancy, retinal hemorrhage, breast-feeding. Intravenous injection of the drug is unacceptable in the uncontrolled flow of arterial hypotension, atherosclerosis of the cerebral and coronary arteries of pronounced character, with arrhythmia. With instability of blood pressure, after surgery, with ulcerative lesions of the digestive system, chronic heart failure, pathology of the kidney and liver systems, the drug is administered with caution.

Side effects

Nervous system: convulsive syndrome, anxiety, dizziness, headaches.
Skin: increased fragility of the nail plates, swelling, hyperemia of the skin, "hot flashes" to the skin of the face and body.
Digestive system: cholestatic hepatitis, exacerbation of cholecystitis, intestinal atony, decreased appetite, dry mouth.
Cardiac system: cardialgia, arrhythmia, tachycardia, a drop in blood pressure, progression of angina pectoris.
Possible visual impairment, scotoma, thrombocytopenia, intestinal bleeding, allergic reactions, anaphylactic shock, increased activity of hepatic enzymes, alkaline phosphatase.

Instructions for use Pentoxifylline (Method and dosage)

Pentoxifylline solution, instructions for use

The drug in the ampoules is administered intramuscularly and intraarterially in the prone position.
With the pathology of the renal system, the dosage is reduced to 50-70 percent of the standard dose.
Intravenously injected slowly, calculated according to the scheme: 50 mg for every 10 ml of sodium chloride 0.9%, injected 10 minutes, then switch to the introduction of a dropper: 100 mg diluted in 250-500 ml of sodium chloride 0.9% or a solution of dextrose 5 %.
Intraarterial: 100 mg is diluted in 20-50 ml of sodium chloride.
Intramuscularly injected three times a day for 100-200 mg.

Tablets Pentoxifylline, instructions for use

It is permissible in addition to parenteral administration to take the drug inside after eating twice a day for 800-1200 mg. The initial daily dosage in tableted form is 600 mg, gradually the amount of the drug is reduced to 300 mg per day. Prolonged forms of the drug are taken twice a day.

Overdose

Admission of increased doses of Pentoxifylline causes a drop in blood pressure, dizziness, tachycardia, syncope, hyperthermia, agitation, tonic-clonic convulsions, areflexia, vomiting "coffee grounds" and other signs of bleeding from the digestive tract. It requires timely washing of the digestive system, intake of enterosorbents, and asymptomatic therapy. With the development of bleeding, urgent measures are taken to stop bleeding.

Interaction

Pentoxifylline is able to enhance the effectiveness of medications that affect the operation of the blood coagulation system (thrombolytic agents, anticoagulants), antibacterial drugs, valproic acid. Pentoxifylline increases the effectiveness of oral hypoglycemic agents, insulin, hypotensive medications. Cimetidine is able to increase the level of the drug in the blood, which means that the risk of side effects increases. With a joint appointment with other xanthines there is a nervous excitement.

Storage conditions

In a place inaccessible to children at a temperature of no more than 30 degrees Celsius.
Shelf life - 3 years.

special instructions

Treatment with Pentoxifylline is carried out under the control of blood pressure. Patients with diabetes require additional correction of dosages of hypoglycemic agents. With the simultaneous appointment of anticoagulants, control over the blood coagulation system is required. In patients after surgery, hemoglobin and hematocrit are monitored. With instability of blood pressure, the dose of the drug is reduced. Tobacco smoke reduces the effectiveness of the drug. The compatibility of infusion solutions with Pentoxifylline should be checked before each infusion.
Pentoxifylline is often used in bodybuilding and sports. This is due to the fact that the drug improves blood circulation, causing a strong "pumping", which can last several hours. However, it should be remembered that this drug is medicinal, and you should not joke about your health, taking such medicines uncontrollably.

Reviews about Pentoxifylline

Based on many opinions, it can be concluded that the drug is really effective, helping to cope with the problems of the vascular system. Effectively helps with the improvement of blood supply.
It is often and effectively used for obliterating endarteritis.
Reviews about Pentoxifylline during pregnancy
Although the drug is contraindicated in this period of life (due to a lack of research), it is often prescribed by doctors with fetoplacental insufficiency, for example, a dropper of Pentoxifylline during pregnancy. In general, the opinions of those who used the medicine were positive, no side effects were observed.