Vasonit tabs 600mg #20

Tablets Vasonit instruction for use

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Composition

In the composition of 1 tablet Vasonit 600 mg contains 600 mg of active ingredient (Pentoxifylline) and excipients: hypromellose 15000 cP, microcrystalline cellulose, crospovidone, colloidal silicon dioxide, magnesium stearate.
The composition of the envelope includes: macrogol 6000, talc, titanium dioxide, hypromellose 5 cP, polyacrylic acid as a 30% dispersion.

Form of issue

Drug drug prolonged action, film-coated, oblong, white, biconvex, with a risk on both sides - 2 blisters of 10 pcs. in a cardboard box.

pharmachologic effect

The Vasonit has the following pharmacological action:
    improves microcirculation of blood in places of circulatory disorders by improving the rheological properties of blood (fluidity);
     protects the walls of blood vessels from harmful effects (angioprotective action);
     relaxes the smooth muscles of the walls of blood vessels (vasodilating action);
     suppresses the blood's ability to thrombogenesis (anti-aggregation effect);
     improves the supply of tissues with oxygen.

Pharmacodynamics and pharmacokinetics

The active substance Vasonit - Pentoxifylline improves blood circulation in small blood vessels in places where this blood supply is disturbed. This is due to improving the fluidity of the blood and some expansion of small blood vessels.
Blood flow is increased by restoring the normal form of erythrocytes and platelets and suppressing the process of their aggregation (gluing or adherence with subsequent thrombus formation). Under the influence of Vasonit in the blood, the level of the fibrinogen protein decreases, which also participates in the process of formation of thrombi and fibrinolysis is increased - the process of dissolution of thrombi. A small expansion of the blood vessels further improves the circulation of the tissues concerned.
In addition, Vasonit improves the supply of oxygen to the tissues - all this contributes to the improvement of cellular metabolism and the restoration of normal vital functions of organs and tissues.
With a decrease in permeability of peripheral arteries, arising, for example, against the background of atherosclerosis, improvement of blood circulation in the area of ​​affected limbs leads to the fact that it becomes easier for a patient to walk, reduce or disappear completely cramps calf muscles.
After taking Vasonit inside its active ingredient is gradually and almost completely absorbed in the gastrointestinal tract, providing a long-term effect of the drug. After absorption, pentoxifylline decomposes in the liver with the formation of pharmacologically active metabolic products. The maximum concentration in the blood is reached after 3 to 4 hours, the therapeutic effect persists for 12 hours.
Vasonit is excreted in the urine in the form of metabolic products. Part of the drug can be excreted with feces and breast milk.
With severe renal dysfunction, the products of pentoxifylline exchange are eliminated from the body more slowly, which requires a lower dosage of the drug. If there is a violation of liver function, pentoxifylline increases the bioavailability of the drug, which also requires a revision of the dosage.

Indications for use of the Vasonit

Vasonit is prescribed for the following diseases and conditions:
     any violations of the arterial blood circulation, including those associated with inflammation of the walls of blood vessels, atherosclerosis, diabetes mellitus, and with impaired innervation of peripheral vessels (Raynaud's disease); against frostbite and gangrene;
     disorders of blood circulation in the brain region associated with changes in the patency of blood vessels and insufficient supply of oxygen to the brain;
     in the complex treatment of the consequences of ischemic stroke, accompanied by a violation of intelligence and concentration of attention;
     metabolic-dystrophic disorders from the brain (encephalopathies);
     violations of venous circulation against a background of varicose veins, thrombophlebitis and related trophic ulcers;
     with visual and hearing impairments associated with circulatory disorders in these areas.

Contraindications for the use of Vasonit

Vasonit is contraindicated:
     with myocardial infarction in an acute period;
     with hemorrhage in the brain (hemorrhagic stroke);
     with visual impairment associated with hemorrhages;
     with any significant bleeding;
     during pregnancy and breastfeeding of the child;
     children and adolescents under the age of 18 (no clinical trials have been performed);
     with individual intolerance of the components of the Vasonit.
Caution requires the appointment of Vasonit in the atherosclerosis of cerebral vessels and the heart, low blood pressure, heart rhythm disturbances, circulatory system, liver and kidney function disorders, ulcerative lesions of the gastrointestinal tract, postoperative period and with increased bleeding (eg menstrual and intermenstrual uterine bleeding) and in old age.
Patients with impaired renal and hepatic function, as well as elderly patients and those with low blood pressure should be given this medication in an individually selected dosage below the recommended dosage.

Vasonit drug - side effects

Vasonit has quite a lot of side effects from other organs and systems.
From the side of the central nervous system is a strong dizziness, down to fainting, headache, drowsiness or insomnia, convulsive alertness; there were isolated cases of meningitis. Dizziness can create an obstacle in driving a vehicle, so during treatment it is not necessary to get behind the wheel.
On the part of the circulatory system - increased heart rate, heart rhythm disturbances, heart pain (including angina attacks), lowering blood pressure (sometimes sharp and significant).
From the viewpoint - a violation of visual acuity, loss of fields of peripheral vision.
On the part of the organs of the gastrointestinal tract - a decrease in appetite, dry mouth, nausea, vomiting, diarrhea, alternating with constipation, heaviness and pain in the stomach.
From the liver and biliary tract - pain in the right subcostal area, transient violations of the liver, exacerbation of chronic inflammation of the bile duct and gallbladder (chronic cholangitis and cholecystitis).
On the part of the blood system - increased bleeding, bleeding from internal organs, gums, nosebleeds, a decrease in the blood content of all cellular elements, primarily platelets and leukocytes. It is also possible the development of anemia.
From the skin and its appendages - the flow of blood to the upper half of the trunk and to the face, puffiness, fragility of the nail plates.
The medicine can cause allergy, which manifests itself in the form of hives, Quincke's edema, skin rash and itching. It is possible to develop a severe allergic reaction in the form of anaphylactic shock.

Vasonit - instructions for use

Vasonit is recommended for taking 600 mg twice a day after meals, without chewing and washing with water.
Individual patients dosage of the drug, the same duration of taking the tablets is selected by the doctor individually.
Thus, the instruction for the use of Vasonit for the treatment of patients with impaired liver and kidney function, low blood pressure and in old age recommends a reduction in the standard dosage.

Overdose of the Vasonit

Overdose Vasonit is quite possible. It manifests itself in a sharp decrease in blood pressure, accompanied by nausea, palpitations, shortness of breath, weakness, a feeling of lack of air, red face and upper body, chills. Sometimes this state ends with loss of consciousness and convulsions. If the patient has ulcerative lesions of the gastrointestinal tract or trophic ulcers, bleeding is possible.
If you suspect an overdose, call an ambulance right away. Before her arrival, you should wash your stomach and drink several tablets of activated charcoal.

Interaction of Vasonit with other medications

The medicinal preparation interacts with many medicinal substances, it intensifies the action:
     drugs that suppress the effect of the blood coagulation system - direct and indirect anticoagulants, etc .;
     antibiotics from the group of cephalosporins (for example, ceftriaxone);
     Valproic acid - a drug with an anticonvulsant effect;
     drugs that lower blood pressure;
     medicines for the treatment of diabetes mellitus.
When taking with theophylline, an overdose of the latter may occur.
When taken together with cimetidine, there is a risk of overdose of the Vasonit.

Terms of sale

You don't need a prescription bo buy Vasonit online.

Storage conditions

The drug should be stored in a dry place inaccessible to the sun and children, at a temperature of no higher than 25 ° C.
Shelf life - 5 years.

Alcohol and Vasonit

Alcohol intake during treatment Vasonit is contraindicated. Smoking reduces the therapeutic effect of this drug.

Reviews about Vasonit

In general, reviews on this drug are positive, with the introduction of Vasonita in the complex treatment of various diseases with impaired peripheral circulation, the condition of patients is gradually improving. But all vascular diseases are difficult to treat and require long-term comprehensive treatment under the supervision of a doctor.
Negative reviews on Vasonit 600 mg are associated mainly with side effects and an overdose of this drug. That is why Vasonit should be prescribed by a doctor taking into account all indications and contraindications.