Pradaxa caps 110mg #60

Pradaxa instruction for use

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Composition

The composition of 1 capsule contains: dabigatran ethexylate mesylate 172.95 mg (150 mg in terms of dabigatran etexilate) + additional substances (tartaric acid, dimethicone, acacia gum, hypromellose, talc, hydroxypropylcellulose, potassium chloride, E407, E171, E132, E110, water, butanol, ethanol, isopropanol, shellac, propylene glycol, E172).
There is also a dosage form containing dabigatran etexilate 75 and 110 mg.

Form of issue

Opaque capsules, oblong. The color is cream-yellow (inscription R150) and blue (the inscription is a symbol of the company). Inside the capsules the pellets are pale yellow.
Blisters of 10 capsules, in packages of 10, 30, 60 pieces (1,3,6 blisters respectively). Bottles of 60 capsules.
INN: dabigatran etexylate.

pharmachologic effect

Medication Pradaxa - a direct anticoagulant, thrombin inhibitor.

Pharmacodynamics and pharmacokinetics

The active substance of the tablet, after conversion into dabigatran, inhibits the activity of the thrombin enzyme, which in turn is responsible for the process of converting fibrinogen into fibrin and the formation of a thrombus. Also, dabigatran has the ability to reduce the activity of already formed thrombi, free thrombin, fibrin-bound thrombin, subsequent aggregation of platelets does not occur.
The active component effectively reduces the prothrombin index, in direct proportion to its concentration in the blood plasma, achieved during the drug administration.
Almost immediately after taking the drug, a hydrolysis reaction takes place, converting dabigatran etexilate to dabigatran. The bioavailability of dabigatran is about 6%, the maximum concentration of the active substance will be observed in an hour or two, after administration. Regardless of the dose, the half-life is between 11 and 14 hours. In patients with renal insufficiency, some pharmacokinetic parameters change.

Indications for use

As a rule, the drug is prescribed for prophylaxis:
    venous and systemic thromboembolism;
    stroke.
Also indications for use is atrial fibrillation (to reduce the mortality rate after fibrillation).

Contraindications

The medicine Pradaxa is contraindicated:
    with drug allergy to the active substance, its derivatives and other components;
    at violations in the work of the liver;
    severe renal failure;
    a greater likelihood of bleeding due to stomach ulcers, malignant neoplasms, brain or spinal cord injuries, vascular aneurysm and other pathologies;
    an artificial heart valve;
    when combined with other anticoagulants, ketoconazole, cyclosporine, intraconazole.

Side effects

Possible:
    thrombocytopenia and anemia, intracranial bleeding;
    formation of hematomas, occurrence of bleeding of various origin and location, including from postoperative wounds, nose, stomach and intestines;
    bronchospasm, hypersensitivity reactions, such as urticaria, pruritus and rash;
    diarrhea, abdominal pain, indigestion, nausea, dysphagia, impaired liver function;
    hemarthrosis, hematuria;
    bleeding, poor healing, formation of hematomas and discharge from wounds, drainage from wounds.

Instructions for use Pradaxa (Method and Dosage)

Dosage and duration of admission should be prescribed by a doctor.
According to instructions on Pradaxa, the daily dosage is about 100-300 mg. The drug is taken twice a day.
The specialist should adjust the dosage in the presence of kidney disease, bleeding, the elderly and the combination of the drug with P-glycoprotein inhibitors.

Overdose

Significantly increases the risk of bleeding.
In case of an overdose, a coagulation test should be performed. A positive effect is the conduct of hemodialysis, bleeding should be eliminated, and the place of their occurrence should be identified. As a rule, blood transfusion is effective.

Interaction

Do not combine with drugs that affect hemostasis, vitamin K antagonists, P-glycoprotein inhibitors (verapamil, ketoconazole, clarithromycin, amiodarone, quinidine).
Use with caution in combination with dronedarone, St. John's wort, carbamazepine and Pantoprazole.
Acetylsalicylic acid, in combination with Pradaxa, can significantly increase the risk of bleeding.

Terms of sale

A prescription is not required to buy Pradaxa online.

Storage conditions

In a place inaccessible to children. The temperature is not higher than 25 degrees.
Shelf life - 3 years. After opening the vial with tablets, they should be used within 4 months.

Which is better: Pradaxa or Warfarin?

Warfarin is the most used antagonist of vitamin K, and has a lot of limitations to use. It is necessary to constantly monitor the INR, the drug is not combined with all products and medicines. Not at all, it turns out to maintain the required level of INR, which leads to undesirable side effects or a decrease in the effectiveness of the drug. Unlike warfarin, Pradaxa is a means of a new generation, the risk of bleeding in the drug is lower, there are fewer restrictions.
In any case, which of the drugs should be used, Pradaxa or warfarin, should be decided by the attending physician.

Reviews on Pradaxa

Reviews on Pradaxa are good. Especially flattering about the drug doctors respond, compare the drug with Warfarin and note a lot of advantages over other anticoagulants. Given that this remedy for prevention and drinking it takes quite a long time, many are confused by the high price of the drug and some of the emerging side effects.