Xarelto tabs 15mg #28

Xarelto instruction

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Composition

The tablet of the preparation contains: rivaroxaban micronized in the amount of 10, 15 or 20 mg, and auxiliary components: microcrystalline cellulose, croscarmellose sodium, hypromellose 5cP, lactose monohydrate, magnesium stearate and sodium lauryl sulfate.
The film coating of the tablet coating consists of: iron dye red oxide, hypromellose 15cP, titanium dioxide and macrogol 3350.

Form of issue

Xarelto is available in tablets coated with a film membrane with different contents of the active substance. They have a round biconvex shape, pink or reddish-brown color, bilateral engraving - on the one hand - a triangle and the designation of the dosage, and on the other, a firm Bayer cross is applied. On sale are offered packages from 5 to 100 pieces.

pharmachologic effect

A drug that inhibits factor Xa, an anticoagulant of direct action.

Pharmacodynamics and pharmacokinetics

For the active substance of this drug - rivaroxaban, characterized by rapid effects, predictable dose-response and high bioavailability. It does not require monitoring of coagulation parameters, there is practically no risk of incompatibility with other food products or drugs.
The drug is used as a prophylactic against stroke in patients suffering from atrial fibrillation, while demonstrating good efficacy and tolerability. This anticoagulant can be taken once a day, observing a fixed dose.
Rivaroxaban has a high absolute bioavailability of 80-100%. The main component is rapidly absorbed with the onset of maximum concentration after 2-4 hours. Getting into the body, there is a significant connection of the main part of rivaroxaban with the proteins of the blood plasma, namely plasma albumin. Excretion of the drug is carried out mainly in the form of metabolites.

Indications for use of Xarelto medication

The main indications are:
    prevention of venous thromboembolism, after large-scale orthopedic operations in the lower limbs;
    prevention of stroke and systemic thromboembolism in non-valvular atrial fibrillation and so on.

Contraindications for use

    active bleeding affecting especially important organs, for example, GIT, intracranial region and so on;
    liver disease accompanied by coagulopathy, which causes a risk of bleeding;
    lactation, pregnancy;
    age of patients, less than 18 years;
    congenital insufficiency or intolerance of lactase, glucose-galactose malabsorption;
    high sensitivity to rivaroxaban and other excipients.

Side effects

Treatment Xarelto can cause various undesirable phenomena affecting almost all organs and systems. In this case, they often appear in a moderate degree.
The most common side effects are:
    anemia;
    nausea, transaminase, increased GGT activity;
    hemorrhage after procedures, including postoperative anemia and bleeding from wounds.
Rarely arise:
    thrombocythemia, increased platelet count;
    tachycardia, arterial hypotension;
    constipation, diarrhea, pain and discomfort in the abdomen, dyspepsia, dry mouth;
    dizziness, headache, short-term loss of consciousness;
    bleeding from the digestive tract, nose, hematuria, hemorrhage from the genital tract;
    local swelling, worsening of general health, fever, allergic reactions and so on.

Instructions for Xarelto (Method and dosage)

As the instruction on application of Xarelto informs, in the period of VTE prevention after significant orthopedic operations patients are prescribed daily intake of 10 mg of the drug. The duration of therapy is 2-5 weeks, depending on the scale and complexity of the intervention.
This drug can be taken at any time, regardless of eating. To start treatment Xarelto need 6-10 hours after the operation, if you reach hemostasis. If you miss a dose, you should immediately take Xarelto's medication, and the next day you need to continue therapy as usual.

Overdose

In an overdose of rivaroxaban, hemorrhagic complications commonly associated with the pharmacodynamic features of the drug usually develop. At present, the specific antivot of rivaroxaban has not been developed.
To reduce the absorption of rivaroxaban, it is recommended that activated charcoal be taken within 8 hours.

Interaction

You should know the drug interaction before you buy Xarelto.
Simultaneous use of Xarelto with the strongest inhibitors of the isoenzyme CYP3A4 and P-gp can cause a decrease in renal and hepatic clearance, which leads to a significant increase in the systemic effect and pharmacodynamic effect of the drug.
It was found that Clarithromycin, Erythromycin and Fluconazole may lead to different changes in the concentration of rivaroxaban, but this is considered the order of normal variability and is clinically insignificant.
It is necessary to refrain from the joint use of rivaroxaban and dronedarone, since there is no clinical data on this combination.
The administration of Xarelto and rifampicin, which belongs to the strong inducers of CYP3A4 and P-gp, leads to a decrease in the pharmacodynamic effects of the drug. Therefore, treatment with this drug with other strong inducers should be done with caution.

Storage conditions

Keep the tablets out of the reach of children, at temperatures below 30 ° C.
Shelf life - 3 years.

Alcohol and Xarelto

Clinical studies have shown that treatment with this drug is completely incompatible with alcohol, as this can lead to the development of undesirable consequences.

Reviews of Xarelto

In general, reviews about Xarelto contain discussions about the risk of active or latent bleeding affecting any tissues or organs, which often leads to anemia of a posthemorrhagic nature. At the same time, patients' reviews of Xarelto, who took the drug, contain information about frequent hemorrhagic complications in the form of: weakness, dizziness, pallor, dyspnea, swelling, and so on.
Also, the responses on the forums are vivid discussions about the high cost, which is not available to all patients.