Preductal OD caps 80mg #60

Preductal user manual

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Composition

The contents of the Preductal tablets include the main component: trimetazidine dihydrochloride.
Additional constituents: calcium hydrophosphate dihydrate, povidone, hypromellose, magnesium stearate, silicon dioxide colloid, macrogol 6000, dry pink premix for the shell.

Form of issue

Preductal is produced in the form of tablets, which are packaged in 30 pieces in blisters for 2, 3, 6 or 10 blisters in a pack.

pharmachologic effect

The drug is characterized by an antihypoxic effect, which also improves energy metabolism.

Pharmacodynamics and pharmacokinetics

The main substance trimetazidine (this and a drug) is able to prevent the decrease in the concentration of adenosine triphosphate inside cells, due to the conservation of energy metabolism at the cellular level in the state of hypoxia. In this case, according to Wikipedia, normal operation of membrane ion channels, transmembrane transfer of potassium or sodium ions is provided, and cellular homeostasis is maintained.
Preductal medication activates several complex processes in the body, due to which the full protection of the myocardium from possible ischemia is provided.
Pharmacological properties of trimetazidine allow you to switch energy metabolism from oxidation of fatty acids to glucose.
In general, with ischemia for trimetazidine is characteristic:
    support of energy cardiac metabolism and neurosensory tissues;
    decrease in the intensity of intracellular acidosis and some changes related to the transmembrane ion flow;
    decrease in the level of infiltration and migration of polynucleated neutrophils in the ischemic and reperfused heart tissues;
    decrease in the size of myocardial damage.
At the same time, there is no direct effect on the parameters of hemodynamics.
With regard to the treatment of patients suffering from angina, it usually happens:
    an increase in the coronary reserve, which slows the development of ischemia, which causes physical activity;
    limitation of fluctuations in blood pressure during physical exertion, without having a special effect on the heart rate;
    reduction in the frequency of angina attacks and the need for short-acting nitroglycerin;
    improvement of the contractile function of the left ventricle with ischemic dysfunction.
After ingestion of the tablets, Preductal is rapidly absorbed, and the maximum concentration in the blood plasma is then reached, after about 5 hours. At the same time, its concentration persists for 24 hours. Eating food does not affect the bioavailability of the drug. The basic substance is well distributed in tissues and body fluids.
Removal of the drug occurs mainly with the help of the kidneys, in an unmodified form.

Indications for use of Preductal

The main indications for the use of Preductal MV in the complex or monotherapy with:
    prolonged treatment of coronary heart disease;
    prevention of attacks of stable angina.

Contraindications

Take the drug Preductal is contraindicated when:
    sensitivity to it;
    Parkinson's disease, Parkinson's symptoms, tremor, restless legs syndrome and other motor disorders;
    severe renal failure;
    the age of 18 years;
    lactation, pregnancy.
Caution is necessary when prescribing a drug for patients with severe or moderate hepatic and renal failure.

Side effects

When receiving Preductal MR can develop a variety of adverse reactions affecting the work of the digestive, nervous, cardiovascular, circulatory, lymphatic and other systems.
This manifests itself: abdominal pain, diarrhea, nausea, vomiting, constipation, dyspepsia, dizziness, headaches, tachycardia, heartbeat failures and so on.
Possible side effects, manifested on the skin - rash, itching and hives.

Tablets Preductal, instructions for use (Method and dosage)

Instructions for use Preductal MR recommends taking the pills inside, in a general way, with plenty of water.
This medication is prescribed in a daily dosage of one tablet to a 2-time dose. Preferably in the morning and evening, at the same time as food.
Detailed instructions Preductal MR reports that the duration of treatment is set by the doctor. In this case, the drug can be taken in a maximum daily dosage of up to 70 mg.
It should be noted that the instructions for the use of Preductal MR allocates treatment for specific groups of patients. Therefore, for example, people with renal failure Preductal mr is prescribed in a daily dosage of 35 mg. Take the medicine better in the morning, at the same time with breakfast.
During the treatment of patients from the age of 75, development of an increased exposure to trimetazidine may be excluded due to the age-related decline in kidney function. Dosage Preductal MR for this group of patients is selected only by a doctor.

Overdose

Admission Preductal mr rarely leads to the development of an overdose. But if this still happens, then therapy is performed, depending on the symptomatology that has manifested itself.

Interaction

The drug Preductal MR does not enter into pharmacological interaction with other drugs.

special instructions

It is established that Preductal MR is not designed for the removal of angina attacks, therefore it is not recommended to use it for the treatment of unstable angina, as well as myocardial infarction at the initial stage or in the early days of hospitalization.
The fact is that Preductal MR often causes or intensifies the symptoms of parkinsonism, for example, tremor, akinesia and tone increase. For this reason, regular monitoring of patients is required. If treatment is in doubt, then an appropriate examination with a neurologist is necessary.
If there are motor disorders, for example: Parkinsonism symptoms, restless legs syndrome, tremor, instability and "unsteadiness" of the gait, you should immediately cancel the pill. Such cases occur quite rarely and usually the symptoms disappear after the drug is discontinued.
Although there is no specific effect on hemodynamic parameters, dizziness and drowsiness may occur. Therefore, in the period of treatment to drive vehicles and perform work that requires rapid reactions, it should be done with the utmost care.

Terms of sale

The prescription is not needed to buy Preductal online.

Storage conditions

Preductal MR does not require special conditions for the storage of tablets. It is important that they are not accessible to children.
Shelf life - 3 years.

Alcohol

During the treatment, alcohol is prohibited.

Reviews about Preductal

Numerous reviews about the Preductal MR indicate that it should be taken with extreme caution. However, some users think differently, although they do not even know exactly what tablets are prescribed by doctors.
Sometimes some experts in the field of cardiology also show disbelief in Preductal mr. Therefore, reviews of cardiologists differ in their diversity. The fact is that the action of Preductal has not been fully studied and not one forum contains discussions on this topic. In the opinion of some specialists, its effectiveness is equated with bioadditives. Doctors prescribe a drug to improve the condition of the myocardium, constantly monitoring the patient's condition, and if the positive result does not come, make an adequate replacement.
It is interesting that many patients who suffer from coronary heart disease and angina say that when treated with this drug, they feel a significant improvement. They also note a reduction in the number of seizures, from which the medicine helps best.
Thus, it becomes clear that Preductal mr can not be the only and basic treatment, but it can significantly improve a person's well-being. Such drugs help to normalize the metabolism and the work of the heart muscle, so they are also considered "vitamins for the heart." Even if they do not return health to the heart, but significantly improve the work of the body, preventing the development of any malfunctions and irregularities.