Vessel Due F solution for injections 600LE/2ml 2ml #10

Vessel Due F solution instruction for use

You can buy Vessel Due F solution on this page

Release form, composition and packaging

Solution for in / in and in / m the introduction of light yellow or yellow, transparent.
1 amp
sulodexide 600 LE *
Excipients: sodium chloride - 18 mg, water d / and - up to 2 ml.

pharmachologic effect

Anticoagulant direct action. The active substance of the drug Vessel Due F solution - sulodexide - is a natural product, extracted and isolated from the mucous membrane of the small intestine of the pig. It is a natural mixture of glycosaminoglycans: a heparin-like fraction with a molecular weight of 8,000 daltons (80%) and dermatan sulfate (20%).
It has an anticoagulant, antithrombotic, angioprotective and profibrinolytic action.
The anticoagulant action is manifested due to the affinity for heparin cofactor II, which inactivates thrombin.
The mechanism of antithrombotic action is associated with the suppression of activated X factor, increased synthesis and secretion of prostacyclin (PG I2), with a decrease in the level of fibrinogen in the blood plasma.
The profibrinolytic effect is due to an increase in the level of tissue plasminogen activator in the blood and a decrease in the content of its inhibitor.
The mechanism of angioprotective action is associated with the restoration of the structural and functional integrity of the vascular endothelium cells, and the restoration of the normal density of the negative electric charge of the pores of the basal membrane of the vessels.
In addition, Vessel Due F solution normalizes the rheological properties of blood by reducing the level of triglycerides (because it stimulates the lipolytic enzyme - lipoprotein lipase, which hydrolyzes triglycerides, which are part of LDL).
The efficacy of the drug in diabetic nephropathy is determined by the ability of sulodexide to reduce the thickness of the basement membrane and the production of extracellular matrix by reducing the proliferation of mesangium cells.

Pharmacokinetics

Suction and distribution

After oral administration, sulodexide is absorbed from the small intestine. 90% of sulodexide is absorbed by the vascular endothelium, which exceeds its concentration in the tissues of other organs by 20-30 times.

Metabolism

Metabolized in the liver and kidneys. Unlike unfractionated heparin and low molecular weight heparins, sulodexide does not undergo desulfation, which leads to a decrease in antithrombotic activity and significantly accelerates elimination from the body.

Removal

Excreted by the kidneys after 4 h after injection.
After i / v administration, after 24 hours, urinary excretion is 50%, after 48 hours, 67%.

Indications

- Angiopathies with an increased risk of thrombosis, incl. and after myocardial infarction;
- violation of cerebral circulation, including the acute period of ischemic stroke and the period of early recovery;
- dyscirculatory encephalopathy due to atherosclerosis, diabetes mellitus, arterial hypertension;
- vascular dementia;
- occlusive lesions of peripheral arteries of both atherosclerotic and diabetic genesis;
- phlebopathy, deep vein thrombosis;
- microangiopathy (nephropathy, retinopathy, neuropathy);
- macroangiopathy in diabetes mellitus (diabetic foot syndrome, encephalopathy, cardiopathy);
- thrombophilic states, antiphospholipid syndrome (prescribed in conjunction with acetylsalicylic acid, as well as following low molecular weight heparins);
- treatment of heparin-induced thrombotic thrombocytopenia (since Vessel Due F solution does not cause or aggravate it).

Contraindications

- hemorrhagic diathesis and diseases accompanied by low blood clotting;
- I trimester of pregnancy;
- hypersensitivity to the drug.

Dosage

At the beginning of therapy, Vessel Due F solution is injected parenterally in / m or / in (bolus or drip) 2 ml (1 ampoule) of solution for injection (600 LU) for 15-20 days. To prepare the solution for on / in the introduction of the contents of 1 ampoule diluted in 150-200 ml of saline.
Then move on to the drug inside. Assign 1 capsule (250 LU) 2 times / day for 30-40 days.
Capsules take between meals.
The full course of treatment should be repeated at least 2 times a year.
Depending on the results of the patient’s clinical diagnostic examination, the dosage regimen may be changed.

Side effects

On the part of the digestive system: nausea, vomiting, epigastric pain.
Allergic reactions: skin rash of various localization.
Local reactions: pain, burning, hematoma at the injection site.

Overdose

Symptoms: bleeding or bleeding.
Treatment: drug withdrawal; if necessary, conduct symptomatic therapy.

Drug interaction

Clinically significant interaction of the drug Vessel Due F solution with other drugs is not installed.
When using sulodexide, it is not recommended to use anticoagulants (direct and indirect) and antiplatelet agents simultaneously.

special instructions

When using Vessel Due F solution, control of the coagulogram is necessary. At the beginning and end of treatment, it is advisable to determine the following indicators: APTT, antithrombin III, bleeding time and clotting time. Vessel Due F increases normal APTT values ​​by approximately 1.5 times.
Influence on ability to drive motor transport and control mechanisms
Vessel Due F solution does not affect the ability to drive vehicles and control mechanisms.

Pregnancy and lactation

Use in the first trimester of pregnancy is contraindicated.
There is a positive experience with sulodexide in patients with type 1 diabetes in the second and third trimesters of pregnancy for the treatment and prevention of vascular complications during the development of late toxicosis in pregnant women.
To use the drug Vessel Due F solution during pregnancy in the II and III trimesters should be strictly under the supervision of a physician.
Data on the use of Vessel Due F solution during lactation (breastfeeding) are not provided.

Pharmacy sales terms

You don't need a prescription to buy Vessel Due F solution.

Terms and conditions of storage

List B. The drug should be kept out of the reach of children at a temperature not higher than 30 ° C. Shelf life - 5 years.