Acnecutan caps 8mg #30

Acnecutan user manual

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Composition

The chemical composition of Acnecutan depends primarily on the form of release of the drug. One capsule of size 3 or 1 contains 8 or 16 mg, respectively. a highly active compound of isotretinoin.
In addition, the composition of the drug includes such auxiliary substances as: purified soybean oil, complexes of substances Gellucir 50/13 (esters of stearic acid, glycerol and polyethylene oxide), and Span0 (sorbitol and esters of oleic acid).
The capsule shell contains titanium dioxide, gelatin, red iron oxide, and indigocarmine (10 mg).

Form of issue

Hard gelatin capsules, brown No. 3 (8 mg.) Or No. 1 (10 mg.). The contents of the capsules are a waxy paste, differing in an orange-yellow hue. In a cardboard package there can be 1,2,4, and also 7 blisters for 14 capsules or 2,3,5,6,9 blisters for 10 or 14 capsules.

pharmachologic effect

The drug has anti-inflammatory and anti-seborrheic abilities, and also has a regenerating effect on the skin.

Pharmacodynamics and pharmacokinetics

Due to the presence of isotretinoin in the drug, Acnecutan improves the clinical picture in severe forms of acne, which are not amenable to other types of therapeutic treatment. Although the exact mechanism of action of the active drug compound is not fully understood, the drug helps to suppress the activity of the sebaceous glands.
Since sebum is the best medium for the development of harmful bacteria Propionibacterium acnes, which cause the formation of acne, a reduction in the size of the sebaceous glands and a decrease in their activity leads to a slowing of the bacterial colonization of the duct.
Acnecutan acts on acne, suppressing the proliferation of sebocytes, thus restoring the process of cell differentiation, while stimulating regeneration. Isotretinoin, contained in the drug, has an anti-inflammatory effect on the skin.

Indications for use

The main contraindications for the drug are:
    lactation period;
    pregnancy;
    liver failure;
    hyperlipidemia;
    hypersensitivity;
    hypervitaminosis A.
Acnecutan is not recommended for use in the treatment of children under 12 years of age. It is necessary to treat with caution the patients suffering from diabetes, alcoholism, as well as violations of lipid metabolism, with obesity and depression.

Side effects

When using the drug, symptoms of hypervitaminosis A may occur, ie, dry skin, conjunctivitis, nosebleeds, hoarseness, intolerance to contact lenses may appear. Acnecutan can cause such dermatological reactions as: skin peeling, sweating, paronychia, itching and rash, dermatitis, onychodystrophy, photosensitivity, and acne exacerbation.
In addition, adverse reactions with the use of Acnecutan can be observed from the side:
    digestive system, for example, diarrhea, bleeding, inflammation of the gums, pancreatitis;
    central nervous system - nausea, headache, visual impairment, convulsions seizures;
    sensory organs - photophobia, xerophthalmia, keratitis, neuritis, hearing impairment;
    respiratory system and expressed in bronchospasm
    the circulatory system in the form of neutropenia, anemia, leukopenia, a decrease in hematocrit.

Instructions for the use of Acnecutan (Method and dosage)

Capsules with an active drug compound are best taken with food no more than 2 times a day. The dosage of Acnecutan depends on the severity of the disease and the patient's health. The recommended initial dose is 0.4 mg. for each kilogram of body weight per day.
In severe forms of acne, the dosage of the drug can be increased to a maximum of 2 mg. for each kilogram of body weight per day. Complete remission in patients is observed approximately on the 24th day of use of the drug. Particular attention to the dosage of the drug should be paid to patients with renal insufficiency.

Overdose

In case of an overdose of Acnecatan, symptoms of hypervitaminosis of group A. appear. To eliminate the negative consequences of non-compliance with the recommended dosage of the drug, you should rinse the stomach and stop using the medication.

Interaction

The efficacy of Acnecutan can lower antibiotics related to the tetracycline series. To avoid burns, do not take medications that increase photosensitivity together with the drug. The risk of developing type A hypervitaminosis increases retinoids, which are also not recommended for use with this medication.
Isotretinoin, contained in the drug, can reduce the effectiveness of contraceptives with a small amount of progesterone. In order to rule out the increase in irritation, Acnecutan is not used together with keratolytic drugs.

Storage conditions

The medicine is stored at a temperature of 25 C, in a place protected from light.
Shelf life - 2 years.

special instructions

Before the onset and during therapeutic treatment with Acnecutan, liver function, as well as the level of lipids, triglycerides and liver enzymes should be monitored.
During treatment, patients are advised to avoid direct sunlight and not to neglect moisturizing creams, and also to use products to help prevent dry skin and lips.
It is not recommended to resort to laser treatment or chemical dermabrasion during the period of drug use.
The drug can have an effect on concentration of attention, so it is worth to be cautious in approaching driving with Acnecutan.

Children

Not used in the treatment of children under 12 years.

During pregnancy (and lactation)

Acnecutan is forbidden to use during pregnancy and lactation.

Reviews about Acnecutan

We can say that the vast majority of reviews on the Acnecutan in the forums are positive. However, not everyone agrees on this drug, because it has many side effects. In addition, some reviews of patients talking about the short-term effect of an expensive drug, make us doubt the actual benefits of this drug.