Differin cream 0.1% 30gr

Differin cream user manual

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Composition of the preparation

for 1 g of cream
Active substance: adapalene 1.0 mg
Auxiliary substances: carbomer 974P (934P) 4.5 mg, macrogol methyldextrose sesquistearate 35.0 mg, glycerol 30.0 mg, squalane natural 60.0 mg, methyldextrose sesquistearate 35.0 mg, disodium edetate 1 , 0 mg, methylparahydroxybenzoate 2.0 mg, propyl parahydroxybenzoate 1.0 mg, phenoxyethanol 5.0 mg, cyclomethicone 130.0 mg, sodium hydroxide (up to pH 6.5 ± 0.15), water purified to 1 in

Description

cream of white color.

Pharmacotherapeutic group

Acne rash remedy.
ATX code: (D 10 AD 03)

Pharmacological properties

Adapalene is a retinoid metabolite, has a comedonolytic and anti-inflammatory activity, normalizes the processes of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific γ-receptors of skin epidermal cells. As a result of the action of adapalene, in particular, there is a decrease in the "cohesion" of epithelial cells at the mouth of the sebaceous-hair follicle and a reduction in the prerequisites for the formation of micro-comedones. Adapalene has an anti-inflammatory effect in vivo and in vitro, affecting inflammatory factors by inhibiting the migration of leukocytes in the focus of inflammation and the metabolism of arachidonic acid.

Pharmacokinetics

Absorption of adapalene through the skin is very low (about 4% of the applied dose). Excretion from the body occurs mainly through bile.

Indications for use

Acne.

Contraindications

Hypersensitivity to one of the ingredients of the drug.

Pediatric Use

Differin cream is intended for use in adults and children over 12 years of age.

Pregnancy and breastfeeding

It is not recommended to use the drug during pregnancy.
Differin cream can be used during breastfeeding.
To avoid contact exposure to the baby, do not apply Differin cream on the skin of the breast.

Carefully

Dermatitis, eczema.

Dosing and Administration

Outwardly. With a gentle touch, apply the cream evenly on the affected surface once a day before going to bed to clean, dry skin, avoiding the cream in the eyes and lips.
The therapeutic effect develops after 4-8 weeks of treatment, a persistent improvement after 3 months of treatment.
In some cases, due to short-term skin irritation, the number of applications may be reduced or the treatment suspended until the signs of irritation disappear.
Repeated treatment is possible after consultation with a doctor.

Side effects of Differin cream

The frequency of adverse reactions is distributed in the following order: often (in 1% - 10% of cases); infrequently (in 0.1% - 1% of cases); rarely (in 0.01% - 0.1% of cases); very rarely (less than 0.01% of cases), including reports of single adverse events.
From the skin and subcutaneous fat:
Often: dry skin, skin irritation, burning sensation of the skin, erythema.
Infrequent: contact dermatitis, a feeling of discomfort, sunburn, itching, skin peeling, acne.
The frequency is unknown (pharmacovigilance data): soreness of the skin, swelling of the skin.
On the part of the organs of vision:
The frequency is unknown (pharmacovigilance data): eyelid irritation, itchy eyelids, eyelid swelling, erythema in the eyelid region.
In case of skin irritation development, treatment should be suspended until irritation disappears or frequency of application is reduced.

Drug Interactions

Since Differin cream does not interact with oxygen and does not break down under the influence of light, it can be used with other local and systemic drugs for the treatment of acne, such as clindamycin phosphate or benzoyl peroxide.

special instructions for Differin cream

Avoid contact with eyes and mucous membranes.
If you accidentally get Differin cream on the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water.
Avoid direct sunlight. may cause mild skin irritation. Treatment can be continued if the solar exposure is minimized (using sunglasses and hats).
It is not recommended simultaneous use of cosmetic products with drying or irritating effect on the skin (for example, perfume or alcohol-containing products).
Adapalene, applied to the skin in the evening, can be combined with drugs for the treatment of blackheads, applied in the morning.

Overdose

Overdose is unlikely.

Form of issue

Cream for external use 0.1% to 30 grams in an aluminum tube, with an internal epoxy-phenolic coating, with an aluminum membrane and a tightly screwed polypropylene lid with a tube puncher.
On 1 tube together with the instruction on application place in a cardboard box.
Shelf life - 3 years. Do not use after expiry date.

Storage conditions

At a temperature of no higher than 25 ° C. Do not freeze.
Keep out of the reach of children.

Terms of leave from pharmacies

You can buy Differin cream without a prescription.