Exorolfinlac nail polish 5% 2.5ml

Exorolfinlac user manual

You can buy Exorolfinlac here

Pharmacological properties

Pharmacodynamics

Antifungal drug for external use. It has a fungistatic and fungicidal effect due to damage to the cytoplasmic membrane of the fungus through disruption of the biosynthesis of sterols. The content of ergosterol decreases, the content of atypical steric non-planar sterols accumulates.
It has a wide spectrum of action.
It is highly active against both the most common and rare pathogens of fungal nail infections:
Dermatophytes: Trichophyton spp., Microsporum spp., Epidermophyton spp .;
Yeast fungi: Candida spp., Cryptococcus spp., Malassezia spp. (Pityrosporum spp.);
Mold fungi: Alternaria spp., Scopulariopsis spp., Hendersonula spp .;
Fungi from the family Dematiaceae: Cladosporium spp., Fonsecaea spp., Wangiella spp.
Dimorphic fungi: Coccidioides spp., Histoplasma spp., Sporothrix spp.

Pharmacokinetics

When applying the solution to the nails, amorolfine penetrates the nail plate and then into the nail bed (almost completely during the first 24 hours). The effective concentration of amorolfine is retained in the affected nail plate for 7–10 days after the first application. Systemic absorption is insignificant: plasma amorolfine concentration is below the detection limit of detection methods (less than 0.5 ng / ml).

Indications for use

    treatment of fungal nail infections caused by dermatophytes, yeasts and molds;
    prevention of fungal infections of the nails.

Contraindications

    hypersensitivity to amorolfine and other components of Exorolfinlac;
    age up to 18 years.

Use during pregnancy and during breastfeeding

Due to the limited data on the use of amorolfine in pregnant and lactating women, the use of the drug during pregnancy and during breast

Dosage and administration

Outwardly. Apply to the affected nails of the fingers or toes 1-2 times a week as follows:
Before use, remove, if possible, the affected areas of the nail (especially from its surface) using the attached nail file.
Then clean and degrease the surface of the nail with the accompanying cleaning cloth.
Before each subsequent use of Exorolfinlac, it is also necessary to treat the affected nails with a file and then remove the remaining layer of nail polish with a cleaning cloth.
Lower the applicator into the bottle with nail polish and then carefully remove it without wiping off the excess nail polish on the bottle neck.
Using the applicator, apply the lacquer evenly on the entire surface of the affected nail.
The above procedure is repeated for each affected nail.
Allow the nail polish to dry for approximately 3 minutes.
Wipe the applicator with a cleaning cloth used to clean the nail, while avoiding contact with treated nails and a cleaning cloth. Tightly close the vial immediately after the procedure.
    Discard used napkin.
    Applying decorative nail polish is possible no earlier than 10 minutes after applying nail polish Exorolfinlac.
    When you reuse the drug Exorolfinlac, you must carefully remove the remaining decorative nail polish from the nails, then use the supplied nail files to treat the affected nails and remove the remaining layer of nail polish with cleansing wipes. Wash your hands thoroughly after the procedure. If the nail polish was applied to the nails on the hands, wait until it is completely dry.
    After the nail polish has dried, regular washing of the hands and feet with soap is allowed.
    Treatment should be continued until the nail is regenerated and the affected area is completely cured.
    The average duration of treatment is 6 months for fingernails and 9-12 months for toenails.
    Due to the slow growth of the nail plates, the first signs of improvement can become noticeable only after 2-3 months of Exorolfinlac. In the absence of signs of improvement after 3 months, it is recommended to consult a doctor.

Side effect

With the use of the drug Exorolfinlac, undesirable reactions are rarely observed.
Nail damage such as discoloration, destruction of nail plates, brittle nails, can be the result of fungal nail infections.
All adverse reactions noted with the use of the drug Exorolfinlac are presented below in accordance with the accepted classification by organ systems and frequency of occurrence: very often (> 1/10), often (from> 1/100 to <1/10), infrequently ( > 1/1000 to <1/100), rarely (from> 1/10000 to <1/1000), very rarely (<1/10000), the frequency is unknown (cannot be estimated based on the available data):
Violations of the skin and subcutaneous tissues:
rarely: nail damage, discoloration, onichoclasia (fragility of the nail plate), onihorexis (fragility of the nail plate);
very rarely: burning sensation of the skin;
frequency is unknown: erythema, pruritus, contact dermatitis, urticaria, blistering.
If any of the side effects indicated in the instructions are aggravated, or any other side effects that are not indicated in the instructions are noted, you should immediately inform your doctor.
Immune system disorders:
frequency unknown: hypersensitivity reactions (systemic allergic reactions).

Pediatric use

Clinical data on the efficacy and safety of Exorolfinlac in children are not available, so it should not be prescribed to children.

Overdose

The drug is used only for external use.
With external use of Exorolfinlac, the development of systemic signs of overdose is not expected. In case of accidental ingestion of the drug, it is necessary to conduct appropriate symptomatic therapy.

Interaction with other drugs

Not studied.

special instructions

    Files used to treat affected nails should not be used to process healthy nails;
    Organic solvents must wear impermeable gloves to protect polished nails.
    during treatment, avoid using false artificial nails;
    the product contains ethanol, therefore, too frequent or improper application may cause irritation or dryness of the skin around the nail;
    cleansing wipe contains highly flammable substance.
Avoid getting nail polish in the eyes, ears and mucous membranes. If nail polish gets into your eyes, rinse immediately with water.
In the event of systemic and / or local allergic reactions, the use of Exorolfinlac should be immediately discontinued and consult a doctor. Using nail polish remover, it is necessary to remove the drug from the nails. Do not apply Exorolfinlac again.
Patients with conditions predisposing to the development of fungal nail infections (impaired peripheral blood circulation, diabetes, immunodeficiencies), as well as patients with nail dystrophy or destroyed nail plate, psoriasis or other chronic skin diseases should consult a doctor.
If more than 2/3 of the nail plate is subject to destruction or fungal damage, you should also consult a doctor for the appointment of concomitant oral therapy.

Influence on ability to drive vehicles and mechanisms

Not studied.

Release form

Nail polish 5%.
On 2.5 ml or 5.0 ml in bottles of dark glass. On 1 bottle complete with cleansing wipes (30 pieces), spatulas (10 pieces) and disposable nail files (30 pieces) together with instructions for use are placed in a pack of cardboard.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
Shelf life - 3 years. The open bottle is stored no more than 6 months.
Do not use after the expiration date printed on the package.

Terms of sell

You don't need a prescription to buy Exorolfinlac.