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Pimafucort 15gr

rating
  • $29.40
  • 3 or more $27.10
  • Availability:In Stock

Instruction for PimafucortReed more and buy Pimafucort on this pageCompositionThe amount of biologically active components does not vary at all depending on the form of production of the pharmaceutical preparation. As in the cream..

Tags: ointment

Instruction for Pimafucort

Reed more and buy Pimafucort on this page

Composition

The amount of biologically active components does not vary at all depending on the form of production of the pharmaceutical preparation. As in the cream, and in the ointment, the basic relationship remains:
    natamycin - 10 mg;
    neomycin sulfate - 3500 units;
    micronized hydrocortisone - 10 mg.
What really distinguishes the variations in release forms to a large extent are the auxiliary substances, there are much more of them in the cream, which indicates a more selective action of the drug. So the harmonious background of the active components is created by:
    F-emulsifier - 115 mg;
    cetyl V 150;
    cetyl ether wax - 60 mg;
    sorbitan stearate - 30 mg;
    macrogol stearate 100 - 20 mg;
    sodium citrate - 14 mg;
    methylparahydroxybenzoate - 2 mg;
    propyl parahydroxybenzoate 0.5 mg;
    Purified water - up to 1000 mg.
The ointment is only an ointment base in the amount of 976.5 mg (in mass fractions it contains 95 percent paraffin and 5 percent PE).

Form of issue

On pharmacy shelves, the drug Pimafucort can be found in two variations:
    white with a yellow tinge cream in aluminum or plastic tubes of 15 grams each. In a cardboard box - 1 tuba.
    ointment from white to yellow, 15 grams in plastic or aluminum tubes (1 tube per pack).

Pharmacological action

Pimafucort - a complex pharmaceutical product, because simultaneously the drug has antibacterial, anti-inflammatory and antifungal effects. Due to the presence of an active ingredient such as neomycin sulfate, which has antibiotic properties, the drug is able to help even in cases of infection with gram-negative microorganisms, for example, Proteus, Klebsiella or Escherichia. Gram-positive bacteria, such as staphylococci or enterococci, also respond well to Pimafucort treatment.
Natamycin, another active substance of the drug, belongs to the pharmaceutical group of macrolides, a subgroup of synthetic polyene, that is, like Neomycin, is an antibiotic by its nature. However, Natamycin is more active against yeast and yeast-like fungi and dermatophytes. With the help of this component, it is possible to defeat such families of microorganisms as Candida, Aspergilus, Trichophyton and others. Natamycin is also active in regard to protozoa, for example, trichomonads and fusarium.
Hydrocortisone completes the three active ingredients of the drug. It is a hormone, because the spectrum of therapeutic effects is the most wide:
    reduces itching sensation;
    reduces the manifestations of inflammation in the pathology of the skin (especially hyperthermia and hyperemia);
    inhibits hypersensitivity reactions;
    suppresses active processes of alteration, exudation and proliferation;
    prevents the activation of phospholipase A2, thus suspending the synthesis of prostaglandins and the release of macrophage chemotactic factor;
    inhibits the activity of hyaluronidase;
    blocks the synthesis and release of sensitized base and eosinophils;
    Suppresses various stages of the local immune process without providing mitostatic action.
Therefore, the question "Pimafucort - hormonal or not?" Should not stand, because the drug does contain active micronized hydrocortisone, which is an active endogenous hormone of the adrenal glands. However, in the context of stereotyped and unreasonable rumors and fears, it is the hormonal basis that creates the variety of the therapeutic effect of the pharmaceutical drug that is observed during the conservative treatment of various diseases.

Pharmacodynamics and pharmacokinetics

The pharmaceutical preparation has a low adsorption threshold on undamaged skin, that is, the active components are not practically absorbed into the body, unless the condition requires it (the bioavailability of hydrocortisone is about 1-3 percent). However, when applied to wound defects (scratches, abrasions, ulcers and so on) or mucous abilities of Pimafucorta are absorbed several times. So eczematous damages take in themselves 2 times better undamaged areas, and lesions of an infectious nature - 4 times.

Indications for use

What helps the Pimafucort ointment is listed in the following list:
    cutaneous mycoses - diseases with a fungal etiology (the cause is the invasion of fungal microorganisms), which affect the skin of the human body;
    superficial dermatosis, if the pathogen of infection is sensitive to the active ingredients of the drug;
    pyoderma - purulent skin damage due to invasion of pathological microorganisms;
    complication of secondary fungal and / or bacterial infection (eg, candidiasis);
    otomycosis - inflammation of the external auditory canal and auricle due to affection by parasitic fungi that grow in the thickness of the skin.

Contraindications

Do not include the cream or ointment Pimafucort in the course of conservative treatment, if available:
    individual hypersensitivity or intolerance to the components of the pharmaceutical preparation;
    cutaneous syphilis;
    rosacea (popularly just "rosacea") - a chronic disease with facial skin lesions due to angioedema and recurrent course;
    ichthyosis (or diffuse keratoma) - congenital pathology of enhanced keratinization of the dermis and its appendages;
    anogenital itching - unpleasant sensations of discomfort in the genital area and anus;
    tuberculosis with the predominant lesion of the skin (extrapulmonary form of the disease);
    acne disease (ordinary acne), regardless of the etiological factor;
    skin reactions after injection;
    skin diseases of oncological origin;
    viral cover lesions;
    side effects from the administration of pharmaceutical preparations of the group of corticosteroids - perioral dermatitis or striae (striped atrophodermia - stretching the skin in the form of white or crimson bands) on the surface of the body;
    increased fragility of the blood vessels of the skin, especially at the site of treatment with the drug.

Side effects

First of all, undesirable reactions are extremely rare, approximately in 0.1% of cases of conservative treatment with cream or ointment Pimafucortom the following side effects can be observed:
    withdrawal syndrome with a sharp discontinuation of the therapeutic course;
    the appearance of striae, if the drug is used in places of permanent skin folds;
    perioral dermatitis;
    atrophy or thinning of the skin;
    telangiectasia ("vascular asterisks") and even purpura;
    hypertrichosis - excessive hair growth on non-conventional skin areas, inappropriate to sex and age;
    hypersensitivity reactions to the components of the drug - skin itching, burning, hyperemia redness, local dryness;
    Increased intraocular pressure and increased risk of developing cataracts, using liniments on the face.

Pimafucort ointment, instructions for use (Method and dosage)

The drug is prescribed in different forms of release for the treatment of various pathologies. So, acute dermatoses are mainly treated with the help of Pimafucorta cream, and chronic, sluggish pathologies are treated with ointment. Especially effective is the ointment, if an occlusive dressing is applied or the skin becomes dry, lichenifications have appeared (secondary morphological element of skin rash in the form of local thickening, pigmentation and enhancement of the pattern).
The pharmaceutical preparation is applied to the uninjured area of ​​the skin 2-4 times a day, depending on the degree of prevalence and severity of the pathological process. Instructions for use Pimafucorta says that the duration of treatment is established by a dermatologist, usually it lasts from 2 weeks to 1 month. It is not recommended to continue treatment for more than 14 days in young children, since their skin is still in the process of forming and applying a pharmaceutical drug can cause side effects much faster than in adults.

Overdose

There is no confirmed information about drug overdose or undesirable effects of elevated ointment concentrations, but there is a theoretical possibility of ototoxic effect, that is, damage to the hearing aid as a result of conservative treatment. This probability appears, if in the treatment of otomycosis and the application of Pimafucorta in the external auditory meatus there are cracks or perforations in the tympanic membrane. Thus, the possibility of Neomycin exposure to the middle ear will be opened, which can lead to damage to it and partial or total loss of hearing.

Interaction

As a rule, there is cross-resistance in previous treatment with antibiotics such as Kanamycin, Paromomycin, Neomycin, Gentamicin and other drugs of the macrolide group.

Storage conditions

Pimafucort should be stored in a dry place, inaccessible to children of young and middle age, at a temperature of no higher than 25 degrees Celsius.

Shelf life

3 years for cream and 5 years for ointment

special instructions

During the use of the drug should be remembered the possibility of developing adrenocortical suppression - a condition where the production of corticosteroids by the adrenal glands is suppressed, since already with hydrocortisone circulates in the systemic circulation. In this case, you should immediately abandon the further use of Pimafucorta and contact a qualified specialist for help.
The active substances of Pimafucorta (Neomycin, Natamycin) are antibiotics, so when conducting conservative treatment, you should follow the general rules of antibiotic therapy:
    Clearly follow recommendations for the duration of drug intake, so that microorganisms do not develop resistance to certain groups of pharmacological drugs.
    Impeccably follow the dosages of the drug.
    Independently do not stop the course of conservative treatment, unless the cause is not in the side effects or unwanted reactions.

Pimafucort analogues

At this point in the pharmaceutical market there is no identical analogue Pimafucort ointment, but there is a combination of drugs, which include glucocorticoids, antifungals and antibiotics in different variations. This is the pharmacological analogues of Pimafucort, because such drugs have similar therapeutic effects and are used to treat similar pathologies:
    Flucinar (Neomycin and Fluocinolone).

Children

The use of the drug for young children (especially for infants and newborns) is categorically contraindicated, since the baby's skin in this young period of development of its own body is still in the process of formation, that is, they are gradually adapting to a new, unusual external environment. Therefore, unwanted reactions or side effects of treatment can manifest much earlier, which is fraught with serious consequences, which are primarily cosmetic.

In pregnancy and lactation

When Pimafucort is included in the scheme of conservative treatment of pregnant or lactating women, it is necessary to remember the possible ototoxic effect of neomycin on the developing organism of the child and mother. It is also not recommended to apply a cream or ointment under the occlusive dressing or use the medicine for a long time, because it is possible to miss the first occurrence of side effects or undesirable reactions of the therapeutic effect of the drug.

Reviews of Pimafucort

Reviews about Pimafucorte are filled with positive emotions. Often there are pleasant impressions of newly mums who use a cream for children to get rid of the first rash on the baby's skin, since the drug has a small number of side effects along with the breadth of the therapeutic effect.
However, there are often reports of useless use of the ointment over a long period of time. Such patients, as a rule, neglect the recommendations of the doctor and independently change Pimafucort to a cheaper analogue, which can not be done in any case, because the dermatologist is acquainted with the pathology of the skin much better.
Clinical cases are also known when, after application of the ointment, the aggravation of the underlying disease occurred. The likelihood of such an outcome is reported by the information insert in the carton of the drug. If the disease has passed into the stage of progression, it is necessary to immediately abandon the further intake of Pimafucort and to consult a qualified specialist in the near future.
In response to the drug, it is often asked whether it is better to have a cream or ointment that is not the only correct answer, because there are differences in indications for the use of a variety of pharmaceutical forms, auxiliary substances that create the necessary background for the full action of the active components. So the cream more effectively fights with the acute pathology of the skin, while the ointment better treats chronic recurrent diseases.

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