Siofor tabs 850mg #60

Siofor instruction for use

You can buy Siofor tablets online

Composition

The preparation Siofor 500 has 500 mg of metformin hydrochloride (active ingredient), as well as povidone, silicon dioxide, magnesium stearate, macrogol (additional substances).
Siofor 850 contains 850 mg of metformin hydrochloride and similar additional substances. Siofor 1000 contains 1000 mg of metformin hydrochloride and similar additional substances.

Form of issue

Siofor is available in the form of white oblong tablets. They are covered with a sheath and have a notch for division from two sides. Packed in blisters of 15 pcs.

pharmachologic effect

Siofor is a hypoglycemic drug that belongs to the biguanide group. The drug has an anti-diabetic effect. It helps inhibit the absorption of glucose from the gastrointestinal tract, increases the sensitivity to insulin of peripheral tissues, slows down the process of glucogenesis. Under the influence of the drug, the utilization of glucose by muscles is activated. Siofor also has a positive effect on lipid metabolism due to hypolipidemic action and on the coagulation system due to fibrinolytic action.
The drug reduces the level of glucose in the blood, helps to reduce body weight in people who suffer from diabetes, reduces appetite.

Pharmacodynamics and pharmacokinetics

The maximum concentration of the drug is achieved 2.5 hours after oral administration. If the food is taken at the same time as the preparation, the absorption slows down and decreases. In healthy people, bioavailability is about 50-60%.
The active substance almost does not bind to plasma proteins.
Removal of the drug occurs unchanged in the urine. The half-life after oral administration is approximately 6.5 h.
If the patient has reduced kidney function, the half-life increases, so plasma concentrations of metformin increase.

Indications for use

Siofor tablets are indicated for use in the treatment of type 2 diabetes, especially if the patient is obese, and diet and exercise do not sufficiently compensate for metabolic processes.

Contraindications

Contraindications for the drug are as follows:
    hypersensitivity;
    diabetes mellitus of the first type;
    diabetic ketoacidosis;
    diabetic precoma, coma;
    cessation of endogenous secretion of insulin in patients with type 2 diabetes mellitus;
    renal, hepatic, respiratory failure;
    myocardial infarction in acute phase;
    severe infectious diseases;
    injuries and surgeries;
    hypoxic conditions;
    enhanced decay processes in the body (tumors, etc.);
    lactic-acidic acidosis;
    chronic alcoholism;
    a diet with a strictly limited caloric content (less than 1000 calories daily);
    childhood;
    period of pregnancy, lactation.

Side effects

When Siofor is taken, the following side effects are possible:
    In the system of the digestive system: at the beginning of the treatment can be felt metallic taste in the mouth, deterioration of appetite, vomiting, abdominal pain, diarrhea. In the process of treatment, these side effects gradually disappear.
    In the system of hematopoiesis: very rarely can megaloblastic anemia develop.
    Skin: In rare cases, allergic reactions develop.
    In rare cases, the manifestation of lactic acidosis.

Instruction on Siofor (Method and dosage)

In general, tablets are taken orally, they should be washed down with plenty of water, not chewed. Dosage is prescribed by the attending physician depending on what level of sugar in the blood is detected in the patient.
The instruction for Siofor 500 is the following: initially 1-2 tablets are prescribed per day, gradually the daily dose increases to three tablets. The largest dose of the drug per day - six tablets. If a person takes more than one tablet a day, it is necessary to divide them into several receptions. Do not increase dosage without first consulting a doctor. Duration of treatment is determined only by a specialist.
Instructions for use Siofor 850 is the following: initially the drug starts with one tablet. Gradually the dose can be increased to 2 tablets. A day can take no more than 3 tablets. If a day is taken more than one pill, you need to divide them into several receptions. Do not increase dosage without first consulting a doctor. The duration of treatment is determined only by a specialist.
Instruction for Siofor 1000 is the following: the reception starts with 1 tablet, a day can take no more than 3 tablets. Sometimes it is necessary to combine the reception of this drug with insulin. You can not use Siofor for weight loss without first consulting a doctor.
Taking the drug with polycystic ovaries is possible only after the approval of such treatment by a doctor.

Overdose

During the research, there was no evidence of hypoglycemia even in the event that a dose exceeding the daily dose was 30 times. Overdose can lead to lactic acidosis. Symptoms of this condition are vomiting, diarrhea, weakness, frequent breathing, loss of consciousness. In this case, hemodialysis is performed. But often to eliminate symptoms allows the intake of glucose or sugar.

Interaction

If Siofor is taken concomitantly with other hypoglycemic drugs, NSAIDs, MAO inhibitors, fibrates, ACE inhibitors, insulin, it is important to monitor glucose levels very carefully and regularly. In this case, the hypoglycemic properties of Siofor may increase.
The effectiveness of the drug may decrease if it is taken in conjunction with thyroid hormones, glucocorticosteroids, progesterone, estrogens, thiazide diuretics sympathomimetics, as well as with nicotinic acid. In this case, it is important to control the level of glycemia, it is possible to adjust the dosage of Siofor.
Simultaneous treatment with cimetidine may increase the likelihood of manifestation of lactic acidosis.

Storage conditions

Store the drug at a temperature not exceeding 25 degrees Celsius. Keep the drug away from children.

Shelf life - 3 years.

special instructions

During the treatment with the drug, it is necessary to closely monitor the functioning of the kidneys of the patient.
If a radiological examination is planned, taking the drug should be stopped before the examination and do not take the drug for another two days after the examination, since the introduction of contrast can provoke kidney failure.
Reception Siofor should be stopped two days before the planned surgical operation, which will be conducted under general anesthesia. Treatment can continue two days after the operation.
Do not combine this drug with those drugs that increase hypoglycemic effects.
Carefully used medicine for the treatment of elderly people who are already 65 years old.
It is recommended to monitor the blood lactate level twice a year. If the intake of Siofor will be combined with other drugs that lower the level of sugar, a person can violate the ability to drive.

Which is better: Siofor or Glucophage?

Glucophage contains as an active ingredient metformin hydrochloride and is used both as a monotherapy for diabetes mellitus of the second type, and in the process of complex treatment. However, this drug, like Siofor, is not used as a means solely for weight loss. Therefore, the question what is better for losing weight, in this case is incorrect.

Children

To date, there are no clear clinical data, so the drug is not used to treat children.

With alcohol

Compatibility with alcohol is bad. Lactoacidosis is possible with Siofor and with alcohol. Testimonies indicate the poor health of people who combined alcohol and this drug. There is also an increased risk of developing hypoglycemia.

For losing weight

The drug effectively reduces the glucose level in the blood, and, first of all, it is prescribed for people with diabetes who are obese. However, doctors do not support those who use Siofor exclusively for weight loss. Nevertheless, reviews of Siofor for weight loss suggest that, first of all, the drug reduces the desire to eat sweet.
Those who subscribe to the forum on how to combine Siofor 500 or Siofor 850 and weight loss, note that weight reduction occurs very quickly, especially in combination with a reduction in calories and physical loads. However, those who take diet pills, and noted side effects - colic, fermentation in the stomach, frequent and loose stool, nausea.
But if a person still decides to try this method of weight loss, you need a clear instruction on how to take Siofor for weight loss. In this case, the drug is used with a minimum dose of the active substance - 500 mg. You need to take the pill either in the process of eating, or before eating.
If you follow a diet when taking the drug, you need to limit one tablet per day. You can not take drugs, if you have heavy loads, combine it with other drugs to reduce weight, laxatives, diuretic drugs. It is necessary to stop the course of treatment at a high temperature, expressed violations of the functions of the gastrointestinal tract. It is not recommended to take the drug for more than 3 months.

In pregnancy

Pregnancy is a contraindication for taking Siofor. The drug is contraindicated during pregnancy. When planning pregnancy, treatment with the drug is also not recommended.

Reviews of Siofor

The doctors comments on Siofor 1000, 850, 500 are mostly positive, however experts emphasize that the drug should be taken exclusively by patients with diabetes, and not by healthy losing weight. The medicine helps to effectively restore normal sugar levels and, in addition, people with diabetes who take Siofor 850 or the drug in other doses, note a reduction in weight.
In the network, you can find many reviews of those who have lost weight with the help of this tool, who say that when you receive it, your appetite really decreases. But feedback on Siofor 500 with diabetes, as well as the opinions of those who took it for weight loss, coincide that after the termination of the course of treatment, weight, as a rule, quickly returns. It is noted and the fact that the tablets have an acceptable price. However, there are also many negative reviews about the side effects that develop in the process of such therapy. In particular, we are talking about the problems in the functioning of the liver, pancreas, intestine, stomach.