Victoza solution 6mg/ml 3ml #2

Victoza instruction for use

You can buy Victoza on this page

Composition

In 1 ml of solution liraglutida 6 mg.
Sodium hydrogen phosphate, hydrochloric acid, propylene glycol, phenol, water for injection as auxiliary substances.

Release form

Solution for subcutaneous injections.
pharmachologic effect - hypoglycemic.

Pharmacodynamics for Victoza

It is an analogue of human glucagon-like peptide-1, which is produced by biotechnology and has 97% similarity with human. It binds to GLP-1 receptors, which are targets for the hormone incretin produced in the body.
The latter stimulates insulin production in response to an increase in blood glucose.
At the same time, the active ingredient of the drug suppresses the production of glucagon. Conversely, hypoglycemia reduces insulin secretion, and does not affect the secretion of glucagon. It reduces weight and reduces the amount of fat mass, dulling the feeling of hunger.
Studies on animals with pre-diabetes led to the conclusion that liraglutide slows down the development of diabetes, stimulates an increase in the number of beta cells. Its action lasts for 24 hours.

Pharmacokinetics

The absorption of the drug is slow, and only after 8–12 hours its maximum concentration in the blood can be traced. Bioavailability is 55%. 98% bound to blood proteins. Within 24 hours, liraglutide does not change in the body. T1 / 2 is 13 hours. His 3 metabolites are eliminated within 6–8 days after injection.

Indications for use

Victoza is used in type 2 diabetes as:
    monotherapy;
    combination therapy with oral hypoglycemic drugs - Glibenclamide, Dibetolong, Metformin;
    combination therapy with insulin, if not effective was the treatment of previous combinations of drugs.
Treatment in all cases is carried out against the backdrop of diet and exercise.

Contraindications for Victoza

    type 1 diabetes;
    hypersensitivity to the drug;
    pregnancy and lactation;
    ketoacidosis;
    severe heart failure;
    colitis;
    age up to 18 years;
    paresis of the stomach.

Side effects

Victoza can cause:
    nausea, diarrhea, vomiting, abdominal pain;
    loss of appetite, anorexia;
    hypoglycemic states;
    headache;
    reactions at the injection site;
    respiratory tract infections.

Instructions for use Victoza (method and dosage)

Introduced n / a, in the abdomen / thigh 1 time per day, regardless of the meal.
It is preferable to enter at the same time of day. The injection site may vary. The drug should not be administered in / in and / m.
Read treatment with 0.6 mg per day. A week later, the dose is increased to 1.2 mg. If necessary, for the best glycemic control in a week increase to 1.8 mg. A dose above 1.8 mg is undesirable.
It is usually used in addition to treatment with Metformin or Metformin + Thiazolidinedione in previous doses. When combined with sulfonylurea derivatives, the dose of the latter should be reduced, since unwanted hypoglycemia is possible.

Overdose

With the introduction of a dose exceeding 40 times the average dose, severe nausea and vomiting develop. Symptomatic therapy is carried out.

Interaction

If taken simultaneously with Paracetamol, it is not necessary to adjust the dose of the latter.
Does not cause significant changes in the pharmacokinetics of atorvastatin.
Dose adjustment of Griseofulvina with simultaneous use of Victoza is not required.
Also, no correction Dozlizinopril and Digoxin.
The contraceptive effect of ethinyl estradiol and levonorgestrel when taken simultaneously with Victosa does not change.
The interaction of the drug with Insulin and Warfarin has not been studied.

Terms of sale

You don't need a prescription to buy Victoza.

Storage conditions

Storage in the refrigerator at 2–8 ° C, storage at room temperature not exceeding 30 ° C is permissible.
Shelf life - 30 months.

Reviews of Victoza

Reviews of doctors about Victoza boil down to the fact that the drug should be used according to indications and only as prescribed by a doctor. Studies have shown that drugs for the treatment of type 2 diabetes, Byetta and Victoza, are effective in combating obesity. This point is important because the key task in treating patients with this diagnosis is weight loss.
The drug is intended for the treatment of diabetes and the prevention of its complications, a positive effect on the cardiovascular system. It does not just reduce the level of glucose, but restores the physiological insulin production in patients with diabetes. In animal experiments it has been proved that under its influence the structure of beta cells and their function are restored. The use of the drug allows a comprehensive approach to the treatment of type 2 diabetes.
Victoza for slimming in some patients with diabetes was used as monotherapy. All patients reported persistent loss of appetite. Blood glucose values ​​were within the normal range during the day, triglyceride levels returned to normal within a month.
The drug was administered at a dose of 0.6 mg once a day for a week, then the dose was increased to 1.2 mg. The duration of treatment is 1 year. The best results were observed in combination therapy with Metformin. During the first month of treatment, some patients lost 8 kg. Doctors want to lose weight from spontaneous taking this drug. Its use is associated with the risk of thyroid cancer and pancreatitis.